Androgen Independent Prostate Cancer Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

SIX2 promotes cell plasticity via Wnt/beta-catenin signalling in androgen receptor independent prostate cancer
In this study, we examined the chromatin landscape of AR-positive prostate cancer cells post-exposure to the AR inhibitor enzalutamide. We identified a novel regulator of cell plasticity, the homeobox transcription factor SIX2, whose motif is enriched in accessible chromatin regions after treatment. Depletion of SIX2 in androgen-independent PC-3 prostate cancer cells induced a switch from a stem-like to an epithelial state, resulting in reduced cancer-related properties such as proliferation, colony formation, and metastasis both in vitro and in vivo. These effects were mediated through the downregulation of the Wnt/β-cat...
Source: Cell Research - March 30, 2024 Category: Cytology Authors: Noora Lepp änen Heidi Kaljunen Eerika Takala Roosa Kaarij ärvi Petri I M äkinen Seppo Yl ä-Herttuala Ilkka Paatero Ville Paakinaho Kirsi Ketola Source Type: research

Mediator kinase inhibition reverses castration resistance of advanced prostate cancer
J Clin Invest. 2024 Mar 28:e176709. doi: 10.1172/JCI176709. Online ahead of print.ABSTRACTMediator kinases CDK19 and CDK8, pleiotropic regulators of transcriptional reprogramming, are differentially regulated by androgen signaling but both kinases are upregulated in castration-resistant prostate cancer (CRPC). Genetic or pharmacological inhibition of CDK8 and CDK19 reverses the castration-resistant phenotype and restores the sensitivity of CRPC xenografts to androgen deprivation in vivo. Prolonged CDK8/19 inhibitor treatment combined with castration not only suppresses the growth of CRPC xenografts but also induces tumor r...
Source: Clinical Prostate Cancer - March 28, 2024 Category: Cancer & Oncology Authors: Jing Li Thomas A Hilimire Liu Yueying Lili Wang Jiaxin Liang Bal ázs Győrffy Vitali Sikirzhytski Hao Ji Li Zhang Chen Cheng Xiaokai Ding Kendall R Kerr Charles E Dowling Alexander A Chumanevich Zachary T Mack Gary P Schools Chang-Uk Lim Leigh Ellis Xiao Source Type: research

A Bee Trp-Arg Dense Peptide with Antiproliferation Efficacy against the Prostate Cancer Cell Line DU145
Curr Issues Mol Biol. 2024 Mar 10;46(3):2251-2262. doi: 10.3390/cimb46030144.ABSTRACTProstate cancer accounts for 14% of male cancer-related fatalities in the UK. Given the challenges associated with hormone-based therapies in the context of androgen-independent prostate cancer, there is an imperative need for research into anticancer drugs. N0821, a peptide belonging to the Trp-Arg dense region and derived from the homologous region of various bee species, shows substantial potential for an anticancer effect. Both MTT assays and 3D spheroid assays were conducted to substantiate its antiproliferation potential and strongly...
Source: Current Issues in Molecular Biology - March 27, 2024 Category: Molecular Biology Authors: Ye-Eun Kim Ki-Young Kim Source Type: research

A Bee Trp-Arg Dense Peptide with Antiproliferation Efficacy against the Prostate Cancer Cell Line DU145
Curr Issues Mol Biol. 2024 Mar 10;46(3):2251-2262. doi: 10.3390/cimb46030144.ABSTRACTProstate cancer accounts for 14% of male cancer-related fatalities in the UK. Given the challenges associated with hormone-based therapies in the context of androgen-independent prostate cancer, there is an imperative need for research into anticancer drugs. N0821, a peptide belonging to the Trp-Arg dense region and derived from the homologous region of various bee species, shows substantial potential for an anticancer effect. Both MTT assays and 3D spheroid assays were conducted to substantiate its antiproliferation potential and strongly...
Source: Mol Biol Cell - March 27, 2024 Category: Molecular Biology Authors: Ye-Eun Kim Ki-Young Kim Source Type: research