Veratramine Inhibits the Cell Cycle Progression, Migration, and Invasion via ATM/ATR Pathway in Androgen-Independent Prostate Cancer

In this study, we discovered that veratramine exerted antitumor effects on AIPC cells. We demonstrated that veratramine significantly inhibited the proliferation of cancer cells via G0/G1 phase arrest induced by the ATM/ATR and Akt pathways. These results suggest that veratramine is a promising natural therapeutic agent for AIPC.PMID:37385965 | DOI:10.1142/S0192415X2350060X

Source: The American Journal of Chinese Medicine - June 29, 2023 Category: Complementary Medicine Authors: Hee-Yeon Kim Seoung-Woo Lee Seong-Kyoon Choi Janbolat Ashim Wansoo Kim Su-Min Beak Jin-Kyu Park Jee Eun Han Gil-Jae Cho Zae Young Ryoo Jain Jeong Yong-Ho Lee Hyohoon Jeong Wookyung Yu Song Park Source Type: research