Androgen Independent Prostate Cancer Research This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Antiproliferative, apoptosis-inducing, and GSTP1 demethylation activities of Ellagitannins isolated from Cornus alba L
This study aimed to prove the prostate cancer chemopreventive activity of compounds isolated from CA. We evaluated these compounds using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and evaluated their NF-κB inhibitory activity and apoptosis-inducing activity using western blot analysis and flow cytometry, respectively. Their DNA methylation activity was also evaluated via a methylation-specific polymerase chain reaction in androgen-dependent (LNCaP) and androgen-independent (PC-3) prostate cancer cell lines. Camptothin B (1), cornusiin B (2), and cornusiin A (3), which were isolated in our...
Source: Natural Product Research - December 23, 2023 Category: Biochemistry Authors: Siyeon Jin Seoyeon Seonu Jun Yin Seyeon Son Jinhyeok Choi Jaeyoon Oh Kyungmi Kim Minwon Lee Source Type: research

Integrative analysis of transcriptomic and metabolomic profiles reveals enhanced arginine metabolism in androgen-independent prostate cancer cells
Prostate cancer is a common solid tumor that affects a significant number of men worldwide. Conventional androgen deprivation therapy (ADT) increases the risk of developing castration-resistant prostate cancer... (Source: BMC Cancer)
Source: BMC Cancer - December 16, 2023 Category: Cancer & Oncology Authors: Xingchen Dai, Xinyi Shi, Mingxiu Luo, Pu Li and Yujing Gao Tags: Research Source Type: research

Cancers, Vol. 15, Pages 5612: Targeting Metabolic Vulnerabilities to Overcome Prostate Cancer Resistance: Dual Therapy with Apalutamide and Complex I Inhibition
This study delves into the specific metabolic dependencies of different PCa subtypes and explores the potential synergistic effects of combining androgen receptor (AR) inhibition (ARN with mitochondrial complex I inhibition (IACS)). We examined the metabolic behaviors of normal prostate epithelial cells (PNT1A), androgen-sensitive cells (LNCaP and C4-2), and androgen-independent cells (PC-3) when treated with ARN, IACS, or a combination. The results uncovered distinct mitochondrial activities across PCa subtypes, with androgen-dependent cells exhibiting heightened oxidative phosphorylation (OXPHOS). The combination of ARN ...
Source: Cancers - November 28, 2023 Category: Cancer & Oncology Authors: Valentin Baumgartner Dominik Schaer Daniel Eberli Souzan Salemi Tags: Article Source Type: research

The Antiproliferation Activity of Ganoderma formosanum Extracts on Prostate Cancer Cells
This study provides a molecular basis of G. formosanum extract as a potential ingredient for treatment of androgen-independent prostate cancer.PMID:37970558 | PMC:PMC10635139 | DOI:10.1080/12298093.2020.1746064 (Source: Mycobiology)
Source: Mycobiology - November 16, 2023 Category: Biology Authors: Cheng-Yen Chiang Kai-Di Hsu Yen-Yi Lin Chang-Wei Hsieh Jui-Ming Liu Tze-Ying Lu Kuan-Chen Cheng Source Type: research

GSE245489 Poly I:C-priming of adipose-derived mesenchymal stromal cells promotes a pro-tumorigenic phenotype in an immunocompetent mouse model of prostate cancer
Contributors : Cosette M Rivera-Cruz ; Shreya Kumar ; Marxa L FigueiredoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusWhile BM-MSC remain the most commonly studied MSC subtype and were the focus of original MSC polarization paradigm reports, MSC derived from other tissues may provide advantages for clinical use such as higher relative abundance and differential functional potential. In our previous work, we had identified phenotypical and functional consequences of TLR3 or TLR4 priming on ASC that partially resembled those previously reported for BM-MSC. In our assessment, LPS-prim...
Source: GEO: Gene Expression Omnibus - November 14, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Cell Plasticity in a Mouse Model of Benign Prostate Hyperplasia Drives Amplification of Androgen-Independent Epithelial Cell Populations Sensitive to Antioxidant Therapy
Am J Pathol. 2023 Oct 10:S0002-9440(23)00366-8. doi: 10.1016/j.ajpath.2023.09.010. Online ahead of print.ABSTRACTBenign prostate hyperplasia (BPH) is caused by the non-malignant enlargement of the transition zone of the prostate gland, leading to lower urinary tract symptoms (LUTS). While current medical treatments are unsatisfactory in many patients, the limited understanding of the mechanisms driving disease progression prevents the development of alternative therapeutic strategies. The probasin-prolactin (Pb-PRL) transgenic mouse recapitulates many histopathological features of human BPH. We here show that these alterat...
Source: The American Journal of Pathology - October 12, 2023 Category: Pathology Authors: Le ïla Dos Santos Francesco Carbone Emeline Pacreau Sekou Diarra Marine Luka Natascha Pigat Manon Baures Emilie Navarro Julien Anract Nicolas Barry Delongchamps Nicolas Cagnard Fr édéric Bost Ivan Nemazanyy Olivier Petitjean Ahmed Hama ï Micka ël Men Source Type: research

Cell Plasticity in a Mouse Model of Benign Prostate Hyperplasia Drives Amplification of Androgen-Independent Epithelial Cell Populations Sensitive to Antioxidant Therapy
Am J Pathol. 2023 Oct 10:S0002-9440(23)00366-8. doi: 10.1016/j.ajpath.2023.09.010. Online ahead of print.ABSTRACTBenign prostate hyperplasia (BPH) is caused by the non-malignant enlargement of the transition zone of the prostate gland, leading to lower urinary tract symptoms (LUTS). While current medical treatments are unsatisfactory in many patients, the limited understanding of the mechanisms driving disease progression prevents the development of alternative therapeutic strategies. The probasin-prolactin (Pb-PRL) transgenic mouse recapitulates many histopathological features of human BPH. We here show that these alterat...
Source: Am J Pathol - October 12, 2023 Category: Pathology Authors: Le ïla Dos Santos Francesco Carbone Emeline Pacreau Sekou Diarra Marine Luka Natascha Pigat Manon Baures Emilie Navarro Julien Anract Nicolas Barry Delongchamps Nicolas Cagnard Fr édéric Bost Ivan Nemazanyy Olivier Petitjean Ahmed Hama ï Micka ël Men Source Type: research

Cell Plasticity in a Mouse Model of Benign Prostate Hyperplasia Drives Amplification of Androgen-Independent Epithelial Cell Populations Sensitive to Antioxidant Therapy
Benign prostate hyperplasia (BPH) is caused by the non-malignant enlargement of the transition zone of the prostate gland, leading to lower urinary tract symptoms (LUTS). While current medical treatments are unsatisfactory in many patients, the limited understanding of the mechanisms driving disease progression prevents the development of alternative therapeutic strategies. The probasin-prolactin (Pb-PRL) transgenic mouse recapitulates many histopathological features of human BPH. We here show that these alterations parallel urodynamic disturbance reminiscent of LUTS. (Source: American Journal of Pathology)
Source: American Journal of Pathology - October 10, 2023 Category: Pathology Authors: Le ïla DOS SANTOS, Francesco CARBONE, Emeline PACREAU, Sekou DIARRA, Marine LUKA, Natascha PIGAT, Manon BAURES, Emilie NAVARRO, Julien ANRACT, Nicolas BARRY DELONGCHAMPS, Nicolas CAGNARD, Frédéric BOST, Ivan NEMAZANYY, Olivier PETITJEAN, Ahmed HAMAÏ, Tags: Regular Article Source Type: research

In Silico Bioinformatics Analysis on the Role of Long Non-Coding RNAs as Drivers and Gatekeepers of Androgen-Independent Prostate Cancer Using LNCaP and PC-3 Cells
This study aimed to profile the aberrantly expressed lncRNAs in androgen-dependent (LNCaP) PCa compared to androgen-independent (PC-3) PCa cells. This was achieved by using a 384-well plate of PCa lncRNA gene panel. Differential expression of ±2 up or downregulation was determined using the CFX Maestro software v2.1. LncSEA and DIANA-miRPath were used to identify the enriched pathways. Telomerase RNA component (TERC) lncRNA was illustrated to participate in various tumourigenic classes by in silico bioinformatics analysis and was thus selected for validation using RT-qPCR. Further bioinformatics analysis revealed the invo...
Source: Current Issues in Molecular Biology - September 27, 2023 Category: Molecular Biology Authors: Mandisa Mbeje Jeyalakshmi Kandhavelu Clement Penny Mmamoletla Kgoebane-Maseko Zodwa Dlamini Rahaba Marima Source Type: research