Antimicrobial Protein LECT2-b Helps Maintain Gut Microbiota Homeostasis via Selectively Targeting Certain Pathogenic Bacteria
In this study, we show that leukocyte-derived chemotaxin-2 (LECT2)-b, a recently discovered AMP, helps maintain gut homeostasis in grass carp (Ctenopharyngodon idella), one of the major farmed fish species globally, by directly regulating the gut microbiota. Knockdown of LECT2-b resulted in dysregulation of the gut microbiota. Specifically, LECT2-b deficiency led to the dominance of Proteobacteria, consisting of proinflammatory bacterial species, over Firmicutes, which includes anti-inflammatory bacteria. In addition, the opportunistic pathogenic bacteria genus Aeromonas became the dominant genus replacing the probiotic ba...
Source: Journal of Immunology - December 1, 2023 Category: Allergy & Immunology Authors: Ya-Zhen Hu Chang-Song Wu Jie Wang Xue-Qing Han Pei-Yue Si Yong-An Zhang Xu-Jie Zhang Source Type: research
Evaluation of the Antimicrobial Activity of Phytochemicals from Tea and Agarwood Leaf Extracts against Isolated Bacteria from Poultry and Curd
In this study, tea and agarwood leaf extracts were analyzed for their antimicrobial activity against both pathogenic and beneficial bacteria. Fresh tea (Camellia sinensis) leaves were collected in three varieties, namely, BT-6 from Sylhet, BT-7 from Moulvibazar, and BT-8 from Habiganj; also, green tea (nonfermented tea), black tea (fully fermented tea), and agarwood (Aquilaria malaccensis) were collected from Sylhet region of Bangladesh. Unlike commercial antibiotics, which have side effects on probiotics (beneficiary bacteria), leaf extract activities were analyzed to check if they had positive effects on probiotics that ...
Source: The Scientific World Journal - November 29, 2023 Category: Science Authors: Shah Rucksana Akhter Urme Syeda Fahmida Ahmed Mohammed Mostafa Al Quadir Mst Rubaiat Nazneen Akhand Mohammad Mehedi Hasan Khan Source Type: research
GSE230658 Transcriptional profiling of rainbow trout infected with Aeromonas salmonicida
In this study, transcriptional profiling of skin by oligonucleotide microarray was applied to rainbow trout individuals infected with A. salmonicida, to identified enriched genes involved in pathogen response. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - November 28, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by array Oncorhynchus mykiss Source Type: research
Pathological changes of highly pathogenic < em > Bacillus cereus < /em > on < em > Pelodiscus sinensis < /em >
This study isolated a highly pathogenic Bacillus cereus strain (Y271) from diseased P. sinensis. Y271 has β hemolysis, containing both Hemolysin BL (hblA, hblC, and hblD), Non-hemolytic enterotoxin, NHE (nheA, nheB, and nheC), and Enterotoxin FM (entFM) genes. Y271 is highly pathogenic against P. sinensis with an LD50 = 6.80 × 103 CFU/g weight. B. cereus was detected in multiple tissues of the infected P. sinensis. Among them, spleen tissue showed the highest copy number density (1.54 ± 0.12 × 104 copies/mg). Multiple tissues and organs of diseased P. sinensis exhibited significant pathological damage, especially the s...
Source: Veterinary Quarterly - November 27, 2023 Category: Veterinary Research Authors: Zidong Xiao Mengmeng Cheng Xiaowei Hu Mingyang Xue Nan Jiang Wei Liu Yuding Fan Yan Meng Chen Xu Yong Zhou Source Type: research
Pathological changes of highly pathogenic < em > Bacillus cereus < /em > on < em > Pelodiscus sinensis < /em >
This study isolated a highly pathogenic Bacillus cereus strain (Y271) from diseased P. sinensis. Y271 has β hemolysis, containing both Hemolysin BL (hblA, hblC, and hblD), Non-hemolytic enterotoxin, NHE (nheA, nheB, and nheC), and Enterotoxin FM (entFM) genes. Y271 is highly pathogenic against P. sinensis with an LD50 = 6.80 × 103 CFU/g weight. B. cereus was detected in multiple tissues of the infected P. sinensis. Among them, spleen tissue showed the highest copy number density (1.54 ± 0.12 × 104 copies/mg). Multiple tissues and organs of diseased P. sinensis exhibited significant pathological damage, especially the s...
Source: Veterinary Quarterly - November 27, 2023 Category: Veterinary Research Authors: Zidong Xiao Mengmeng Cheng Xiaowei Hu Mingyang Xue Nan Jiang Wei Liu Yuding Fan Yan Meng Chen Xu Yong Zhou Source Type: research
