Fibrinolytic Agents in Thromboembolic Diseases: Historical Perspectives and Approved Indications
Semin Thromb Hemost DOI: 10.1055/s-0044-1781451Fibrinolytic agents catalyze the conversion of the inactive proenzyme plasminogen into the active protease plasmin, degrading fibrin within the thrombus and recanalizing occluded vessels. The history of these medications dates to the discovery of the first fibrinolytic compound, streptokinase, from bacterial cultures in 1933. Over time, researchers identified two other plasminogen activators in human samples, namely urokinase and tissue plasminogen activator (tPA). Subsequently, tPA was cloned using recombinant DNA methods to produce alteplase. Several additional derivatives o...
Source: Seminars in Thrombosis and Hemostasis - March 1, 2024 Category: Hematology Authors: Rashedi, Sina Greason, Christie M. Sadeghipour, Parham Talasaz, Azita H. O'Donoghue, Michelle L. Jimenez, David Monreal, Manuel Anderson, Christopher D. Elkind, Mitchell S. V. Kreuziger, Lisa M. Baumann Lang, Irene M. Goldhaber, Samuel Z. Konstantinides, Tags: Review Article Source Type: research
Identification of novel benzoyl hydrazine derivatives as activators of neddylation pathway to inhibit the tumor progression in vitro
AbstractNeddylation modification is frequently overexpressed in many types of human tumors. As a result, targeting neddylation pathway has been identified as viable anticancer therapeutic strategy. The NEDD8-activating enzyme (NAE) serves as a crucial role in a variety of cellular functions. Here, a new library of piperidine analogs was developed, produced and assessed for antiproliferative efficacy against A549, MGC-803, MCF-7KYSE-30 cell lines. The cell-based mechanistic studies showed thatIIb-10 bearing the benzoyl hydrazine motif can selectively inhibit the Neddylation modification of Cullin1 and Cullin3 by inhibiting ...
Source: Medicinal Chemistry Research - March 1, 2024 Category: Chemistry Source Type: research
Comparison of pharmacokinetic properties of alteplase and tenecteplase. The future of thrombolysis in acute ischemic stroke
. (Source: Expert Opinion on Drug Metabolism and Toxicology)
Source: Expert Opinion on Drug Metabolism and Toxicology - February 29, 2024 Category: Drugs & Pharmacology Authors: Alessandro Mar èSimone LorenzutFrancesco JanesCarolina GentileRoberto MarinigYan TereshkoGian Luigi GigliMariarosaria ValenteGiovanni Merlinoa Clinical Neurology, Department of Head, Neck and Neurosciences, Udine University Hospital, Udine, Italyb Stroke Source Type: research
Effect of concomitant usage of alteplase and mechanical thrombectomy for M1 middle cerebral artery occlusion on clinical outcome: a retrospective analysis of 457 patients from two centers
ConclusionUtilization of alteplase alongside EVT for MCA M1 occlusion did not result in excessive ICH occurrences or clinical deterioration. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - February 28, 2024 Category: Neurology Source Type: research
Efficacy of urokinase and alteplase intravenous thrombolysis in the treatment of acute phase cerebral infarction and impact on serum S-100 β and nerve growth factor levels
. (Source: International Journal of Neuroscience)
Source: International Journal of Neuroscience - February 28, 2024 Category: Neuroscience Authors: Lei ZhangSi WangNannan RenCerebrovascular Disease, Jinan Central Hospital, Jinan, China Source Type: research
Can the combination of antiplatelet or alteplase thrombolytic therapy with argatroban benefit patients suffering from acute stroke? a systematic review, meta-analysis, and meta-regression
ConclusionThe results of this study suggest that further research into combination therapy with argatroban and antiplatelet agents may be warranted, however more rigorous RCTs are needed to definitively evaluate the effects of combination treatment. (Source: PLoS One)
Source: PLoS One - February 27, 2024 Category: Biomedical Science Authors: Haiyan Xie Source Type: research
Identification of novel benzoyl hydrazine derivatives as activators of neddylation pathway to inhibit the tumor progression in vitro
AbstractNeddylation modification is frequently overexpressed in many types of human tumors. As a result, targeting neddylation pathway has been identified as viable anticancer therapeutic strategy. The NEDD8-activating enzyme (NAE) serves as a crucial role in a variety of cellular functions. Here, a new library of piperidine analogs was developed, produced and assessed for antiproliferative efficacy against A549, MGC-803, MCF-7KYSE-30 cell lines. The cell-based mechanistic studies showed thatIIb-10 bearing the benzoyl hydrazine motif can selectively inhibit the Neddylation modification of Cullin1 and Cullin3 by inhibiting ...
Source: Medicinal Chemistry Research - February 15, 2024 Category: Chemistry Source Type: research
Risk Factors and Prognosis of Early Neurological Deterioration after Bridging Therapy
CONCLUSION: It was found that the incidence of END after BT in AIS patients was 33.67%. An increase in SBP, higher glucose levels at admission, and LAA were independent risk factors of END that predicted a poor prognosis.PMID:38310555 | DOI:10.2174/0115672026287986240104074006 (Source: Current Neurovascular Research)
Source: Current Neurovascular Research - February 4, 2024 Category: Neurology Authors: Yiju Xie Shengyu Li Liuyu Liu Shiting Tang Yayuan Liu Shuangquan Tan Zhijian Liang Source Type: research
Efficacy and safety outcomes of Tenecteplase versus Alteplase for thrombolysis of acute ischemic stroke: A meta-analysis of 9 randomized controlled trials
In recent years, Tenecteplase (TNK), a genetically modified variant of alteplase, has been verified as a potential substitute for alteplase in the reperfusion therapy of acute ischemic stroke (AIS). Given the emergence of new randomized controlled trials (RCTs) of this subject, a meta-analysis was conducted to evaluate the present comparative evidence regarding the efficacy and safety outcomes of TNK and alteplase in thrombolysis for AIS. (Source: Journal of the Neurological Sciences)
Source: Journal of the Neurological Sciences - February 2, 2024 Category: Neurology Authors: Yue Wang, Xiuying Cai, Qi Fang, Juehua Zhu Tags: Review Article Source Type: research
Endovascular thrombectomy without versus with different pre-intravenous thrombolysis in acute ischemic stroke: a network meta-analysis of randomized controlled trials
ConclusionThe use of alteplase before EVT may potentially improve the successful reperfusion after EVT compared to tenecteplase. Due to the insufficient sample size, more high-quality RCTs are needed to confirm effectiveness and safety of tenecteplase compare to alteplase in patients before EVT.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier: CRD42023470419. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - January 29, 2024 Category: Neurology Source Type: research
Multicenter Exploration of Tenecteplase Transition Factors: A Quantitative Analysis
Tenecteplase (TNK) is gaining recognition as a novel therapy for acute ischemic stroke (AIS). Despite TNK offering a longer half-life, time and cost saving benefits; and comparable treatment and safety profiles compared to Alteplase (ALT), the adoption of TNK as a treatment for AIS presents challenges for hospital systems. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - January 22, 2024 Category: Neurology Authors: Sidarrth Prasad, Erica M. Jones, Mehari Gebreyohanns, Yoon Kwon, DaiWai M. Olson, Jane A. Anderson, Sean I. Savitz, Salvador Cruz-Flores, Steven J. Warach, Charlotte E. Rhodes, Mark P. Goldberg, Nneka L. Ifejika Source Type: research
Footloose (footloose), footloose
AbstractA 78-year-old woman without past relevant medical history presented to the emergency department for acute transient dysarthria. NIHSS was 0/42. Neurological examination revealed chorea-like movements over the left limbs, especially the foot. No other neurological signs were present. CT perfusion showed right cortical hypoperfusion due to right M2 occlusion, basal-ganglia perfusion was normal. Brain MRI revealed a small focus of restricted diffusion in the right insula, sparing basal ganglia. Based on the neuroimaging features and clinical correlation, despite the NIHSS score, we decided to treat the patient with al...
Source: Neurological Sciences - January 18, 2024 Category: Neurology Source Type: research
Magnetic Resonance Imaging-Guided Intravenous Thrombolysis in Cardioembolic Stroke Patients With Unknown Time of Onset - Subanalysis of the THAWS Randomized Control Trial
CONCLUSIONS: When an MRI-guided approach is used, CE patients with unknown time of onset appear to be suitable candidates for thrombolysis.PMID:38220173 | DOI:10.1253/circj.CJ-23-0662 (Source: Circulation Journal)
Source: Circulation Journal - January 14, 2024 Category: Cardiology Authors: Naoya Yamazaki Masatoshi Koga Ryosuke Doijiri Manabu Inoue Kaori Miwa Sohei Yoshimura Mayumi Fukuda-Doi Junya Aoki Koko Asakura Makoto Sasaki Takanari Kitazono Kazumi Kimura Kazuo Minematsu Haruko Yamamoto Masafumi Ihara Kazunori Toyoda THAWS Trial Invest Source Type: research
Mechanical thrombectomy with a balloon-guide catheter: sheathless transradial versus transfemoral approach
Conclusions
Comparable patients treated with MT via the sTRA or TFA had similar angiographic and clinical outcomes. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - January 12, 2024 Category: Neurosurgery Authors: Waqas, M., Monteiro, A., Cappuzzo, J. M., Kruk, M. D., Almayman, F., Housley, S. B., Lim, J., Dossani, R. H., Snyder, K. V., Siddiqui, A. H., Davies, J. M., Levy, E. I. Tags: New devices New devices and techniques Source Type: research
Risk prediction models for intracranial hemorrhage in acute ischemic stroke patients receiving intravenous alteplase treatment: a systematic review
ConclusionThis study systematically reviews available evidence on risk prediction models for ICH in acute ischemic stroke patients receiving intravenous alteplase treatment. Few models have been externally validated, while the majority demonstrate significant discriminative power. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - January 5, 2024 Category: Neurology Source Type: research
