In minor, nondisabling, acute ischemic stroke, DAPT was noninferior to IV alteplase for excellent functional outcome at 90 d
Ann Intern Med. 2023 Oct 3. doi: 10.7326/J23-0072. Online ahead of print.ABSTRACTChen HS, Cui Y, Zhou ZH, et al; ARAMIS Investigators. Dual antiplatelet therapy vs alteplase for patients with minor nondisabling acute ischemic stroke: the ARAMIS randomized clinical trial. JAMA. 2023;329:2135-2144. 37367978.PMID:37782921 | DOI:10.7326/J23-0072 (Source: Annals of Internal Medicine)
Source: Annals of Internal Medicine - October 2, 2023 Category: Internal Medicine Authors: Carly Eastin Source Type: research
Effect of admission serum glucose on the clinical prognosis of patients with acute ischemic stroke receiving alteplase intravenous thrombolysis
Conclusions: In patients with acute ischemic stroke receiving intravenous alteplase thrombolytic therapy, a higher admission serum glucose level is an independent predictor of adverse neurological outcomes at 90 days postoperatively.PMID:37771034 | DOI:10.1177/03946320231204597 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - September 29, 2023 Category: Allergy & Immunology Authors: Pan Huang Xingyang Yi Source Type: research
Effect of admission serum glucose on the clinical prognosis of patients with acute ischemic stroke receiving alteplase intravenous thrombolysis
Conclusions: In patients with acute ischemic stroke receiving intravenous alteplase thrombolytic therapy, a higher admission serum glucose level is an independent predictor of adverse neurological outcomes at 90 days postoperatively.PMID:37771034 | PMC:PMC10540570 | DOI:10.1177/03946320231204597 (Source: International Journal of Immunopathology and Pharmacology)
Source: International Journal of Immunopathology and Pharmacology - September 29, 2023 Category: Allergy & Immunology Authors: Pan Huang Xingyang Yi Source Type: research
Efficacy and safety of low dose, weight-based subcutaneous enoxaparin protocol in recurrent arteriovenous access thrombosis
This study aims to evaluate the safety and efficacy of a short-term, low dose, weight-based subcutaneous enoxaparin protocol (SEP) in maintaining the patency of arteriovenous (AV) access with recurrent thrombosis.METHODS: Prospective follow-up of 25 patients who presented to a tertiary institution with recurrent AV access thrombosis and treated with anticoagulation according to SEP following successful thrombectomy. Patency and safety outcomes of SEP were studied.RESULTS: The participants were 66.4 ± 10.2 years old and predominantly male (60%) and of Chinese ethnicity (72%). The AV accesses had a median age of 1.4 (0.6, 5...
Source: The Journal of Vascular Access - September 20, 2023 Category: Surgery Authors: Chye Chung Gan Ru Yu Tan May Anne Cheong Suh Chien Pang Ren Kwang Alvin Tng Chee Wooi Tan Lai Heng Lee Heng Joo Ng Kiang Hiong Tay Tze Tec Chong Chieh Suai Tan Source Type: research
Intracranial hemorrhage in large vessel occlusion patients receiving endovascular thrombectomy with or without intravenous alteplase: a secondary analysis of the DIRECT-MT trial
Conclusions
Our data showed that in the DIRECT-MT trial, alteplase did not increase overall ICH for large vessel occlusion patients treated with thrombectomy, but it increased the parenchymal hematoma rate. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - September 15, 2023 Category: Neurosurgery Authors: Hu, X., Zhou, Y., Ospel, J., Yao, F., Liu, Y., Wang, H., Li, B., Hui, P., Yang, P., Zhang, Y., Zhang, L., Li, Z., Xing, P., Shi, H., Han, H., Wang, S., Fang, Q., Liu, J., for the Direct-MT investigators Tags: Open access, Ischemic stroke Source Type: research
Effect of mechanical thrombectomy with and without intravenous thrombolysis on the functional outcome of patients with different degrees of thrombus perviousness
ConclusionPatients with thrombi of lower perviousness were recommended to undergo intravenous alteplase followed by endovascular thrombectomy, and those with thrombi of higher perviousness could undergo thrombectomy alone. (Source: Neuroradiology)
Source: Neuroradiology - August 29, 2023 Category: Radiology Source Type: research
Influence of time metrics on the treatment effect of intravenous alteplase prior to endovascular treatment in MR CLEAN-NO IV
Conclusion
In MR CLEAN-NO IV, the effect of IVT prior to EVT was not modified by OTR, OTN, DTG or NTG times. Our results do not support the use of these metrics to guide IVT treatment decisions prior to EVT in comprehensive stroke centres.
Trial registration number
ISRCTN80619088. (Source: Journal of NeuroInterventional Surgery)
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Rinkel, L. A., Treurniet, K. M., Kappelhof, M., LeCouffe, N. E., Bruggeman, A. A. E., Nieboer, D., van Zwam, W. H., Uyttenboogaart, M., Dippel, D. W. J., Emmer, B. J., Roos, Y. B. W. E. M., Majoie, C. B. L. M., Coutinho, J. M., on behalf of the MR CLEAN-N Tags: Ischemic stroke Source Type: research
Time to treatment with bridging intravenous alteplase before endovascular treatment:subanalysis of the randomized controlled SWIFT-DIRECT trial
Conclusions
We found no evidence that the effect of bridging IVT on functional independence is modified by overall or in-hospital treatment delays. Considering its low power, this subgroup analysis could have missed a clinically important effect, and exploratory analysis of secondary clinical outcomes indicated a potentially favorable effect of IVT with shorter in-hospital delays. Heterogeneity of the IVT effect size before MT should be further analyzed in individual patient meta-analysis of comparable trials.
Trial registration number
URL: https://www.clinicaltrials.gov ; Unique identifier: NCT03192332 (Source: Journal o...
Source: Journal of NeuroInterventional Surgery - August 29, 2023 Category: Neurosurgery Authors: Meinel, T. R., Kaesmacher, J., Buetikofer, L., Strbian, D., Eker, O. F., Cognard, C., Mordasini, P., Deppeler, S., Mendes Pereira, V., Albucher, J. F., Darcourt, J., Bourcier, R., Guillon, B., Papagiannaki, C., Costentin, G., Sibolt, G., Räty, S., Tags: Open access, Ischemic stroke Source Type: research
Health economic impact of Nerinetide in addition to mechanical thrombectomy without concurrent alteplase
CONCLUSION: Treating patients with a cerebroprotectant, such as Nerinetide, in addition to endovascular treatmentl in patients who cannot receive intravenous alteplase may be beneficial from a health-economic standpoint.PMID:37590087 | DOI:10.1177/15910199231193455 (Source: Interventional Neuroradiology)
Source: Interventional Neuroradiology - August 17, 2023 Category: Radiology Authors: Johanna M Ospel Corey Adams Michael Tymianski Mayank Goyal Michael Hill Source Type: research
Improvement of Functional Outcomes in Patients with Stroke who Received Alteplase for Over 15 Years: Japan Stroke Data Bank
CONCLUSIONS: We revealed that IVT implementation rates in patients with AIS increased, and the functional outcome in these patients improved over 15 years. Therefore, the Japanese IVT dissemination strategy is considered appropriate and effective.PMID:37587045 | DOI:10.5551/jat.64200 (Source: Journal of Atherosclerosis and Thrombosis)
Source: Journal of Atherosclerosis and Thrombosis - August 16, 2023 Category: Cardiology Authors: Akiko Ishigami Kazunori Toyoda Michikazu Nakai Sohei Yoshimura Shinichi Wada Yusuke Sasahara Kazutaka Sonoda Kaori Miwa Junpei Koge Masayuki Shiozawa Yoshitaka Iwanaga Yoshihiro Miyamoto Jin Nakahara Norihiro Suzuki Shotai Kobayashi Kazuo Minematsu Masato Source Type: research
