Pharmacokinetics and safety of fentanyl sublingual spray and fentanyl citrate intravenous: a multiple ascending dose study in opioid-na ïve healthy volunteers.
CONCLUSION: Fentanyl sublingual spray (100 mcg, 200 mg, and 400 mcg) administered every 0.5, 1, 2, and 4 h was generally well tolerated in an opioid-naïve population. The results suggest that doses of 200 mcg or lower may be safe for use in an opioid-naïve population. PMID: 28942715 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - September 27, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Pharmacokinetics and safety of fentanyl sublingual spray and fentanyl citrate intravenous: a single ascending dose study in opioid-na ïve healthy volunteers.
CONCLUSIONS: Overall, single-dose fentanyl sublingual spray (100-800 mcg) was generally well tolerated, with greater incidences of AEs (eg, nausea, vomiting, hypoxia) at higher doses. Doses up to 200 mcg may be safely administered to healthy opioid-naïve individuals with routine monitoring; doses between 400-800 mcg may be administered in settings with nasal cannula oxygenation. PMID: 28681626 [PubMed - as supplied by publisher] (Source: Current Medical Research and Opinion)
Source: Current Medical Research and Opinion - July 8, 2017 Category: Research Tags: Curr Med Res Opin Source Type: research

Battlefield Analgesia in Tactical Combat Casualty Care
Publication date: June 2017 Source:Wilderness & Environmental Medicine, Volume 28, Issue 2, Supplement Author(s): Ian S. Wedmore, Frank K. Butler At the start of the Afghanistan conflict, battlefield analgesia for US military casualties was achieved primarily through the use of intramuscular (IM) morphine. This is a suboptimal choice, since IM morphine is slow-acting, leading to delays in effective pain relief and the risk of overdose and death when dosing is repeated in order to hasten the onset of analgesia. Advances in battlefield analgesia, pioneered initially by Tactical Combat Casualty Care (TCCC), and th...
Source: Wilderness and Environmental Medicine - June 8, 2017 Category: Environmental Health Source Type: research

Continuous wound infiltration system for postoperative pain management in gynecologic oncology patients
ConclusionsCombined therapy using CWIS and IV PCA may be a useful strategy for POSP management in gynecologic oncology patients. (Source: Archives of Gynecology and Obstetrics)
Source: Archives of Gynecology and Obstetrics - April 11, 2017 Category: OBGYN Source Type: research

Opioid-type Respiratory Depressant Side Effects of Cebranopadol in Rats Are Limited by Its Nociceptin/Orphanin FQ Peptide Receptor Agonist Activity
Conclusions The therapeutic window between antinociception and respiratory depression in rats is larger for cebranopadol than that for fentanyl because the nociceptin/orphanin FQ peptide receptor agonist action of cebranopadol counteracts side effects resulting from its μ-opioid peptide receptor agonist action. (Source: Anesthesiology)
Source: Anesthesiology - March 14, 2017 Category: Anesthesiology Source Type: research

Effect of Modulated Electrohyperthermia on the Pharmacokinetics of Oral Transmucosal Fentanyl Citrate in Healthy Volunteers.
This study aimed to determine whether changes occur in fentanyl absorption and disposition when administered in conjunction with modulated electrohyperthermia (mEHT) treatment. METHODS: A randomized, single-dose, crossover, open-label study was used to investigate the effect of mEHT on the pharmacokinetic properties of fentanyl in 12 healthy volunteers. The 12 healthy volunteers were each administered a single dose of oral transmucosal fentanyl citrate (OTFC) or a single dose of OTFC with mEHT. mEHT was performed on the abdomen for 1 hour. Blood samples were collected for 24 hours after dosing. The temperature of t...
Source: Clinical Therapeutics - November 16, 2016 Category: Drugs & Pharmacology Authors: Lee SY, Kim MG Tags: Clin Ther Source Type: research

[Dose-finding for treatment with a transdermal fentanyl patch : Titration with oral transmucosal fentanyl citrate and morphine sulfate].
Abstract To date, no studies investigating titration with oral transmucosal fentanyl for the dose-finding of transdermal fentanyl treatment have been published. In an open randomized study 60 patients with chronic malignant (n = 39) or nonmalignant pain (n = 21), who required opioid therapy according to step three of the guidelines of the World Health Organization (WHO), were investigated. In two groups of 30 patients each titration with immediate release morphine (IRM) or oral transmucosal fentanyl citrate (OTFC) was undertaken. For measurement purposes the Brief Pain Inventory (BPI) and Minimal Docum...
Source: Schmerz - April 11, 2016 Category: Anesthesiology Authors: Mücke M, Conrad R, Marinova M, Cuhls H, Elsner F, Rolke R, Radbruch L Tags: Schmerz Source Type: research

Actiq Is Not for Sore Throats!
No abstract available (Source: Home Healthcare Nurse)
Source: Home Healthcare Nurse - March 1, 2016 Category: Nursing Tags: Ismp Medication Errors Source Type: research

Morphine and Fentanyl Citrate Induce Retrotransposition of Long Interspersed Element-1
The retroelement long interspersed element-1 (LINE-1 or L1) comprises about 17% of the human genome. A single human cell has 80 to 100 copies of retrotransposition-competent L1, approximately 10% of which are ‘hot’ and actively ‘jump’ around the genome. Recent observations demonstrated that low-molecular weight compounds may induce L1 retrotransposition through unknown mechanisms. Herein, we demonstrated that the painkillers morphine and fentanyl citrate trigger L1 retrotransposition in neuronal cells without inducing DNA damage or up-regulating L1 mRNA expression. This effect was blocked by an anta...
Source: In Vivo - February 24, 2016 Category: Research Authors: OKUDAIRA, N., ISHIZAKA, Y., NISHIO, H., SAKAGAMI, H. Tags: Experimental Studies Source Type: research

A new once-a-day fentanyl citrate patch (Fentos® Tape) could be a new treatment option in patients with end-of-dose failure using a 72-h transdermal fentanyl matrix patch
Conclusions A once-a-day fentanyl citrate patch provided stable pain control. Its use may be considered as the dominant strategy for patients receiving a 72-h transdermal fentanyl not lasting 72 h. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - January 28, 2016 Category: Cancer & Oncology Source Type: research

The Influence of Low Salivary Flow Rates on the Absorption of a Sublingual Fentanyl Citrate Formulation for Breakthrough Cancer Pain
Salivary gland hypofunction may affect the absorption of drugs through the oral mucosa, which in turn may affect their clinical efficacy (e.g., onset of action). (Source: Journal of Pain and Symptom Management)
Source: Journal of Pain and Symptom Management - December 16, 2015 Category: Palliative Care Authors: Andrew Davies, Gill Mundin, Joanna Vriens, Kath Webber, Alison Buchanan, Melanie Waghorn Source Type: research

G18 * Breakthrough pain in patients with head and neck cancer: efficacy and safety of buccal fentanyl citrate
(Source: Annals of Oncology)
Source: Annals of Oncology - October 26, 2015 Category: Cancer & Oncology Authors: Rondonotti, D., Platini, F., Giavarra, M., Patrucco, F., Zanotti, V., Negru, M. E., Sponghini, A. P. Tags: Session G. Head and neck cancer Source Type: research

WITHDRAWN: Opioids for the management of breakthrough pain in cancer patients.
CONCLUSIONS: Oral and nasal transmucosal fentanyl is an effective treatment in the management of breakthrough pain. The RCT literature for the management of breakthrough pain is relatively small. Given the importance of this subject, more trials, including head-to-head comparisons of the available transmucosal fentanyl formulations are required. PMID: 26275024 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - August 14, 2015 Category: Journals (General) Authors: Zeppetella G, Davies AN Tags: Cochrane Database Syst Rev Source Type: research

Interaction of fentanyl with various cyclodextrins in aqueous solutions
ConclusionsThis study revealed that hydrophilic β‐CD derivatives, such as G1‐β‐CD, could be useful pharmaceutical additives for oral mucosal formulations because of the improved fentanyl base solubility via inclusion complexation. (Source: Journal of Pharmacy and Pharmacology)
Source: Journal of Pharmacy and Pharmacology - June 16, 2015 Category: Drugs & Pharmacology Authors: Noriko Ogawa, Takayuki Furuishi, Hiromasa Nagase, Tomohiro Endo, Chisato Takahashi, Hiromitsu Yamamoto, Yoshiaki Kawashima, Thorsteinn Loftsson, Masaru Kobayashi, Haruhisa Ueda Tags: Research Paper Source Type: research

A Randomized Crossover Clinical Trial to Evaluate the Efficacy of Oral Transmucosal Fentanyl Citrate in the Treatment of Dyspnea on Exertion in Patients With Advanced Cancer
Conclusion: It could not be demonstrated that the OTFC improved exertion dyspnea in patients with advanced cancer. A placebo effect was observed in all the patients. (Source: American Journal of Hospice and Palliative Medicine)
Source: American Journal of Hospice and Palliative Medicine - April 12, 2015 Category: Palliative Care Authors: Pinna, M. A. C., Bruera, E., Moralo, M. J. R., Correas, M. A. S., Vargas, R. M. Tags: Original Articles Source Type: research