H-Bonded anion –anion complexes in fentanyl citrate polymorphs and solvates
We report the experimental observation (X-ray characterization) of two types of anion –anion complexes (anion = dihydrogen citrate) stabilized by H-bonds that are observed in fentanyl citrate solvates. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - December 6, 2018 Category: Chemistry Authors: Rafael Barbas Source Type: research
H-Bonded anion –anion complexes in fentanyl citrate polymorphs and solvates
We report the experimental observation (X-ray characterization) of two types of anion –anion complexes (anion = dihydrogen citrate) stabilized by H-bonds that are observed in fentanyl citrate solvates. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - December 5, 2018 Category: Chemistry Authors: Rafael Barbas Source Type: research
H-Bonded anion-anion complexes in fentanyl citrate polymorphs and solvates.
Abstract
Herein we report the experimental observation (X-ray characterization) of two different binding modes in H-bonded anion-anion complexes (anion = citrate) in N-(1-(2-phenylethyl)-4-piperidinylium)-N-phenyl-propanamide-citrate (fentanyl citrate). High level DFT calculations indicate that both types of anion-anion complexes (one with two and the other with four H-bonds) are thermodynamically unstable but kinetically stable with respect to the isolated anions with activation barriers as high as 14 kcal mol-1.
PMID: 30516180 [PubMed - as supplied by publisher] (Source: Chemical Communications)
Source: Chemical Communications - December 5, 2018 Category: Chemistry Authors: Barbas R, Prohens R, Bauzá A, Franconetti A, Frontera A Tags: Chem Commun (Camb) Source Type: research
H-bonded anion-anion complexes in fentanyl citrate polymorphs and solvates
Chem. Commun., 2018, Accepted Manuscript DOI: 10.1039/C8CC09028A, CommunicationRafael Barbas, Rafel Prohens, Antonio Bauza, Antonio Franconetti, Antonio Frontera Herein we report the experimental observation (X-ray characterization) of two different binding modes in H-bonded anion –anion complexes (anion = citrate) in N-(1-(2-Phenylethyl)-4-piperidinylium)-N-phenyl-propanamide-citrate (fentanyl citrate). High level DFT calculations indicate that... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Chem. Commun. latest articles)
Source: RSC - Chem. Commun. latest articles - November 27, 2018 Category: Chemistry Authors: Rafael Barbas Source Type: research
Evaluation of Intravenous Parecoxib Infusion Pump of Patient-Controlled Analgesia Compared to Fentanyl for Postoperative Pain Management in Laparoscopic Liver Resection.
CONCLUSIONS Use of the intravenous infusion parecoxib pump for patient-controlled analgesia provides superior analgesic efficacy and fewer adverse effects for patients after laparoscopic liver resection.
PMID: 30439866 [PubMed - in process] (Source: Medical Science Monitor)
Source: Medical Science Monitor - November 17, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Intraoperative pectoral nerve block (Pec) for breast cancer surgery: A randomized controlled trial
Conclusion: Pec II block with ropivacaine delivered under vision reduced analgesic requirement and pain scores significantly. (Source: Journal of Anaesthesiology Clinical Pharmacology)
Source: Journal of Anaesthesiology Clinical Pharmacology - October 11, 2018 Category: Anesthesiology Authors: Mary Thomas Frenny A Philip Arun P Mathew KM Jagathnath Krishna Source Type: research
Trends in Prehospital Analgesia Administration by US Forces From 2007 Through 2016.
CONCLUSIONS: During the study period, rates of prehospital administration of IM morphine remained relatively stable while those for OTFC and ketamine both rose. These findings suggest that TCCC guidelines recommending the use of these agents had a material impact on prehospital analgesia patterns.
PMID: 30118637 [PubMed - as supplied by publisher] (Source: Prehospital Emergency Care)
Source: Prehospital Emergency Care - August 18, 2018 Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research
A Survey of Wilderness Medicine Analgesia Practice Patterns
ConclusionsWilderness medicine practitioners prefer analgesic agents recommended by the WMS for the treatment of acute pain. Respondents most frequently preferred acetaminophen and NSAIDs. (Source: Wilderness and Environmental Medicine)
Source: Wilderness and Environmental Medicine - July 11, 2018 Category: Environmental Health Source Type: research
Pharmacokinetics of Fentanyl Sublingual Spray in Opioid-Na ïve Participants: Results of a Phase 1, Multiple Ascending Dose Study
ConclusionDose-dependent fentanyl pharmacokinetics following multiple doses of fentanyl sublingual spray were well characterized in an opioid-na ïve population.ClinicalTrials.gov identifierNCT02641340. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - June 16, 2018 Category: Drugs & Pharmacology Source Type: research
Pharmacokinetics of fentanyl citrate and norfentanyl in Holstein calves and effect of analytical performances on fentanyl parameter estimation
Journal of Veterinary Pharmacology and Therapeutics, EarlyView. (Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - March 30, 2018 Category: Veterinary Research Source Type: research
A Survey of Wilderness Medicine Analgesia Practice Patterns
Conclusions Wilderness medicine practitioners prefer analgesic agents recommended by the WMS for the treatment of acute pain. Respondents most frequently preferred acetaminophen and NSAIDs. (Source: Wilderness and Environmental Medicine)
Source: Wilderness and Environmental Medicine - March 23, 2018 Category: Environmental Health Source Type: research
Opioids for Pain
Date: April 9, 2018
Issue #:
1544Summary:
Use of nonopioid drugs for pain was reviewed in a
previous issue. For many types of moderate to severe acute pain, acetaminophen and/or an NSAID may be as effective as an opioid. Immediate-release formulations of full opioid agonists should generally be used for acute pain that is severe enough to require treatment with an opioid. Use of extended-release or long-acting opioid formulations initially and treatment durations>1 week have been associated with an increased risk of unintended long-term use. (Source: The Medical Letter)
Source: The Medical Letter - March 21, 2018 Category: Drugs & Pharmacology Authors: admin Tags: Abstral Acetaminophen Actiq Alertec amitiza Antidepressants Apadaz Arymo Aspirin Belbuca benzhydrocodone Buprenex Buprenorphine Butorphanol Butrans Cancer pain capsaicin Codeine Codeine Contin ConZip Dialudid Dolo Source Type: research
Efficacy and feasibility of opioids for burn analgesia: An evidence-based qualitative review of randomized controlled trials
Publication date: Available online 21 November 2017 Source:Burns Author(s): Chao Yang, Xiao-min Xu, Guang-zhao He Opioids are commonly used for burn analgesia, but no comprehensive reviews have been published on such use. We aimed to assess the literature regarding the effectiveness and side effects of opioids both in adult and pediatric burn patients. We conducted a systematic search of the PubMed, Embase, Cochrane, and Web of Science databases. Information on study characteristics, results, and interventions was extracted. The review identified nine studies that satisfied the inclusion criteria. Burn sizes of patien...
Source: Burns - December 16, 2017 Category: Dermatology Source Type: research
Regressive quadriparesis following tracheal resection anastomosis: A rare debilitating but avoidable complication
A 24-year-old male, ASA I patient underwent an uneventful tracheal resection and primary end to end anastomosis. A guardian suture (chin to chest) was placed and the trachea extubated following which the patient was monitored in a seated position. Fentanyl citrate 0.5 μgkg−1h−1 was administered for postoperative analgesia. However (17h postoperatively), the patient complained of uneasiness in the neck along with weakness of both lower limbs (power 1/5) which rapidly progressed to involve the upper limbs too (power 2/5). (Source: Journal of Clinical Anesthesia)
Source: Journal of Clinical Anesthesia - November 2, 2017 Category: Anesthesiology Authors: Akhil Kumar, Ashwin Marwaha, Ameya Pappu, Shikha Sharma, Jayashree Sood Tags: Correspondence Source Type: research
