Extensive epidural spread of cerebrospinal fluid displacing the spinal cord after an inadvertent dural puncture in an obstetric patient
A 24-year-old healthy primipara, body mass index (BMI) 34 kg/m2, had a difficult neuraxial labor analgesia insertion from a combined spinal-epidural (CSE) technique with an 18-gauge Tuohy needle and 27-gauge spinal needle. The first three attempts resulted in paresthesia in the thighs from the spinal needle before successful spinal needle insertion, ide ntification of the clear flow of cerebrospinal fluid (CSF) and intrathecal injection of fentanyl citrate (25 µg in a volume of 2 mL). Dural puncture with the epidural needle was not observed and the epidural catheter was expected to be in the epidural space. (Source...
Source: International Journal of Obstetric Anesthesia - December 5, 2023 Category: Anesthesiology Authors: S. Kaivola, J. Martola, A. V äänänen Tags: Case Report Source Type: research
Extensive epidural spread of cerebrospinal fluid displacingthespinal cord afteraninadvertent dural puncture inanobstetric patient
A 24-year-old healthy primipara, body mass index (BMI) 34 kg/m2, had a difficult neuraxial labor analgesia insertion from a combined spinal-epidural (CSE) technique with an 18-gauge Tuohy needle and 27-gauge spinal needle. The first three attempts resulted in paresthesia in the thighs from the spinal needle before successful spinal needle insertion, identification of the clear flow of cerebrospinal fluid (CSF) and intrathecal injection of fentanyl citrate (25 µg in a volume of 2 mL). Dural puncture with the epidural needle was not observed and the epidural catheter was expected to be in the epidural space. (Source: Intern...
Source: International Journal of Obstetric Anesthesia - December 5, 2023 Category: Anesthesiology Authors: S. Kaivola, J. Martola, A. V äänänen Tags: Case Report Source Type: research
Oral transmucosal fentanyl citrate analgesia in prehospital trauma care: an observational cohort study
Pain is one of the major prehospital symptoms in trauma patients and requires prompt management. Recent studies have reported insufficient analgesia after prehospital treatment in up to 43% of trauma patients,... (Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine)
Source: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine - January 7, 2023 Category: Emergency Medicine Authors: Urs Pietsch, Henning Fischer, Christoph Alexander R üst, Björn Hossfeld, Andreas Grünenfelder, Volker Wenzel and Roland Albrecht Tags: Original research Source Type: research
Dexmedetomidine for sedation during epicardial ablation for ventricular tachycardia: a single-center experience
ConclusionsPrompt availability of anesthesiology support remains crucial for complex procedures such as epicardial VT ablation. Continuous infusion of dexmedetomidine and administration of midazolam and fentanyl seem to be a safe and effective sedation protocol in patients undergoing epicardial VT ablation. (Source: Journal of Interventional Cardiac Electrophysiology)
Source: Journal of Interventional Cardiac Electrophysiology - August 26, 2022 Category: Cardiology Source Type: research
1147 Prehospital oral trans-mucosal fentanyl citrate: preliminary experience and possible implications for civilian mass casualty response
Conclusions
190 patients were included in the data set, the majority having suffered penetrating trauma. We identified an increased need for rescue analgesia and sedation in blunt trauma patients requiring prolonged extrication or limb reduction. 1% (n=2) of patients presented with nausea requiring withdrawal of the lozenge. No patients had adverse features following use of the OTFC lozenge. Our findings were comparable to previous literature on the use of OTFC lozenges.
We argue that the OTFC lozenge has shown to be a safe and rapid method of delivering pre-hospital analgesia during LAA’s routine work. It has the ad...
Source: Emergency Medicine Journal - February 21, 2022 Category: Emergency Medicine Authors: Carenzo, L., McDonald, A., Grier, G. Tags: RCEM Lightning Papers Source Type: research
Nebulized fentanyl for respiratory symptoms in patients with COVID-19 (ventanyl trial)
Patients with coronavirus disease (COVID-19) commonly experience distressing and challenging respiratory symptoms. Interventions such as oxygen therapy, oral opiates, and traditional nebulizers like ipratropium bromide and salbutamol are variable in their efficacy, and therapy responses in patients are difficult to predict. The purpose of this study is to investigate the efficacy of nebulized fentanyl citrate on dyspnea, cough, and throat pain in patients with COVID-19 and evaluate the safety with any potential adverse events.
In COVID-19, about 59% of patients will exhibit cough, 35% generalized body ache and sore thro...
Source: Medicine - January 28, 2022 Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
Pharmacokinetic Characterisation and Comparison of Bioavailability of Intranasal Fentanyl, Transmucosal, and Intravenous Administration through a Three-Way Crossover Study in 24 Healthy Volunteers
CONCLUSION: Pharmacokinetic parameters and bioavailability of the investigated intranasal fentanyl indicated suitability for its intended use as an intranasal PCA option.PMID:34880961 | PMC:PMC8648480 | DOI:10.1155/2021/2887773 (Source: Pain Research and Management)
Source: Pain Research and Management - December 9, 2021 Category: Anesthesiology Authors: S Nardi-Hiebl J W Ndieyira Y Al Enzi W Al Akkad T Koch G Geldner C Reyher L H J Eberhart Source Type: research
Pharmacokinetic Characterisation and Comparison of Bioavailability of Intranasal Fentanyl, Transmucosal, and Intravenous Administration through a Three-Way Crossover Study in 24 Healthy Volunteers
CONCLUSION: Pharmacokinetic parameters and bioavailability of the investigated intranasal fentanyl indicated suitability for its intended use as an intranasal PCA option.PMID:34880961 | PMC:PMC8648480 | DOI:10.1155/2021/2887773 (Source: Pain Research and Management)
Source: Pain Research and Management - December 9, 2021 Category: Anesthesiology Authors: S Nardi-Hiebl J W Ndieyira Y Al Enzi W Al Akkad T Koch G Geldner C Reyher L H J Eberhart Source Type: research
Pharmacokinetic Characterisation and Comparison of Bioavailability of Intranasal Fentanyl, Transmucosal, and Intravenous Administration through a Three-Way Crossover Study in 24 Healthy Volunteers
CONCLUSION: Pharmacokinetic parameters and bioavailability of the investigated intranasal fentanyl indicated suitability for its intended use as an intranasal PCA option.PMID:34880961 | PMC:PMC8648480 | DOI:10.1155/2021/2887773 (Source: Pain Research and Management)
Source: Pain Research and Management - December 9, 2021 Category: Anesthesiology Authors: S Nardi-Hiebl J W Ndieyira Y Al Enzi W Al Akkad T Koch G Geldner C Reyher L H J Eberhart Source Type: research
Pharmacokinetic Characterisation and Comparison of Bioavailability of Intranasal Fentanyl, Transmucosal, and Intravenous Administration through a Three-Way Crossover Study in 24 Healthy Volunteers
CONCLUSION: Pharmacokinetic parameters and bioavailability of the investigated intranasal fentanyl indicated suitability for its intended use as an intranasal PCA option.PMID:34880961 | PMC:PMC8648480 | DOI:10.1155/2021/2887773 (Source: Pain Research and Management)
Source: Pain Research and Management - December 9, 2021 Category: Anesthesiology Authors: S Nardi-Hiebl J W Ndieyira Y Al Enzi W Al Akkad T Koch G Geldner C Reyher L H J Eberhart Source Type: research
An Open-Label Study of the Pharmacokinetics and Tolerability of Once-a-Day Fentanyl Citrate Patch in Japanese Pediatric and Adolescent Patients with Cancer Pain
ConclusionFentanyl citrate patch tended to result in a higher serum fentanyl concentration in pre-school patients than in school-aged, adolescent, and adult patients who received the same dose. The patch provided adequate pain control, was well tolerated, and did not cause respiratory adverse events.Trial Registration NumberJPRN-JapicCTI-183909. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - November 16, 2021 Category: Drugs & Pharmacology Source Type: research
The Newest Battlefield Opioid, Sublingual Sufentanil: A Proposal to Refine Opioid Usage in the U.S. Military
Mil Med. 2021 Sep 29:usab395. doi: 10.1093/milmed/usab395. Online ahead of print.ABSTRACTThere is an ongoing opioid epidemic in the USA, and the U.S. military is not immune to the health threat. To combat the epidemic, the Department of Defense (DoD) and Department of Veterans' Affairs (DVA) issued new clinical practice guidelines and launched the Opioid Safety Initiative aimed at reducing opioid prescriptions. Furthermore, the DoD continually refined opioid protocols for acute pain on the battlefield, evolving from intramuscular morphine to intravenous morphine administration to oral transmucosal fentanyl citrate lollipop...
Source: Military Medicine - September 29, 2021 Category: International Medicine & Public Health Authors: Sharon Y Kim Chester C Buckenmaier Edmund G Howe Kwang H Choi Source Type: research
Impact of Incretin Hormone Receptors on Insulin-Independent Glucose Disposal in Model Experiments in Mice
A large contribution to glucose elimination from the circulation is achieved by insulin-independent processes. We have previously shown that the two incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) increase this process and, therefore, seem to contribute to glucose disposal both through this effect and through the classical incretin effect resulting in enhanced insulin levels. We have now explored in more detail the potential contribution by incretin hormone receptors to insulin-independent processes for glucose elimination. To that end, we have performed intravenous...
Source: Frontiers in Endocrinology - June 8, 2021 Category: Endocrinology Source Type: research
Efficacy and Safety of Fentanyl Citrate Patch, Including a Low-Dose 0.5 mg Formulation, in Opioid-Naïve Patients with Cancer Pain
ConclusionA low-dose fentanyl citrate patch was effective in the management of cancer pain in opioid-na ïve patients and was well tolerated.Study RegistrationJPRN-JapicCTI-173717. (Source: Clinical Drug Investigation)
Source: Clinical Drug Investigation - September 3, 2020 Category: Drugs & Pharmacology Source Type: research
