Molecules, Vol. 29, Pages 1972: Pharmacological Activities of Lonicerae japonicae flos and Its Derivative & mdash; & ldquo;Chrysoeriol & rdquo; in Skin Diseases
Conclusion: The cutaneous route is the best delivery approach to chrysoeriol across the skin barrier. However, toxicity, dosage, and safety assessments of chrysoeriol in a formulation or nanochrysoeriol on the human epidermis for application in skin diseases must be further investigated. (Source: Molecules)
Source: Molecules - April 25, 2024 Category: Chemistry Authors: Siu Kan Law Xiao Xiao Wu Zhou Jiang Christy Wing Sum Tong Wesley Yeuk Lung Chow Dawn Ching Tung Au Tags: Review Source Type: research
Long-term effectiveness and safety of upadacitinib for Japanese patients with moderate-to-severe atopic dermatitis: a real-world clinical study
CONCLUSIONS: Upadacitinib was therapeutically effective and tolerable for moderate-to-severe AD through 48 weeks in real-world clinical practice.PMID:38653561 | DOI:10.1080/09546634.2024.2344591 (Source: Herpes)
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Teppei Hagino Hidehisa Saeki Eita Fujimoto Naoko Kanda Source Type: research
Assessment of the Effect of < em > Rehmannia glutinosa < /em > Leaf Extract in Maintaining Skin Health: A Proof-of-Concept, Double-Blind, Randomized, Placebo-Controlled Clinical Trial
CONCLUSION: RGLE supplementation at a dose of 100 mg/day has provided a clinically relevant decrease in acne severity and improved the skin hydration and quality of life of the participants with acne after 56 days of dose administration.PMID:38651075 | PMC:PMC11034513 | DOI:10.2147/CCID.S448928 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - April 23, 2024 Category: Dermatology Authors: Shalini Srivastava Shu Fen Huang Manjiri S Jagtap Source Type: research
Sophorin mitigate flutamide-induced hepatotoxicity in Wistar rats
In this study,sophorin was used at a dose of 100mg/kg body weight in purified water via oral route for 4 week daily whereas, flutamide was used at a dose of 100mg kg/b.wt for 4 weeks daily in 0.5% carboxy methyl cellulose (CMC) through the oral route for the induction of hepatotoxicity. Flutamide administration leads to enhanced reactive oxygen species (ROS) generation, an imbalance in redox homeostasis and peroxidation of lipid resulted in reduced natural antioxidant level in liver tissue. Our result demonstrated that sophorin significantly abrogate flutamide induced lipid peroxidation, protein carbonyl (PC), and also sig...
Source: Toxicon - April 23, 2024 Category: Toxicology Authors: Rishi Sharma Md Meraj Ansari Manzar Alam Mohammad Fareed Nemat Ali Anas Ahmad Sarwat Sultana Rehan Khan Source Type: research
Long-term effectiveness and safety of upadacitinib for Japanese patients with moderate-to-severe atopic dermatitis: a real-world clinical study
CONCLUSIONS: Upadacitinib was therapeutically effective and tolerable for moderate-to-severe AD through 48 weeks in real-world clinical practice.PMID:38653561 | DOI:10.1080/09546634.2024.2344591 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 23, 2024 Category: Dermatology Authors: Teppei Hagino Hidehisa Saeki Eita Fujimoto Naoko Kanda Source Type: research
Long-term effectiveness and safety of upadacitinib for Japanese patients with moderate-to-severe atopic dermatitis: a real-world clinical study
CONCLUSIONS: Upadacitinib was therapeutically effective and tolerable for moderate-to-severe AD through 48 weeks in real-world clinical practice.PMID:38653561 | DOI:10.1080/09546634.2024.2344591 (Source: Herpes)
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Teppei Hagino Hidehisa Saeki Eita Fujimoto Naoko Kanda Source Type: research
TRPV3 promotes sebocyte inflammation via transcriptional modulating TLR2 in acne
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 20:167195. doi: 10.1016/j.bbadis.2024.167195. Online ahead of print.ABSTRACTAcne is a common chronic inflammatory disease of the pilosebaceous unit. Transient receptor potential vanilloid 3 (TRPV3) is an ion channel that is involved in inflammatory dermatosis development. However, the involvement of TRPV3 in acne-related inflammation remains unclear. Here, we used acne-like mice and human sebocytes to examine the role of TRPV3 in the development of acne. We found that TRPV3 expression increased in the skin lesions of Propionibacterium acnes (P. acnes)-injected acne-like mice and...
Source: Biochimica et Biophysica Acta - April 22, 2024 Category: Biochemistry Authors: Ziyu Wei Meng Gao Yihe Liu Rong Zeng Juan Liu Shuya Sun Siyuan Li Linghan Hu Ruiyu Xiang Ran Mo Zhongya Song Zhiming Chen Dan Bao Di Hua Christos C Zouboulis Yanyan Feng Ji Li Yong Yang Source Type: research
Hidradenitis Suppurativa Online Documents Readability: An Analysis Including 23 European Languages
CONCLUSION: Despite the coverage of HS on the Internet, its complexity made it hard to comprehend. Dermatologist should ensure readable, barrier-free online educational materials. With adequate Google promotion, these would be beneficial for both physicians and patients.PMID:38644990 | PMC:PMC11032155 | DOI:10.2147/CCID.S463861 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - April 22, 2024 Category: Dermatology Authors: Tomasz Skrzypczak Anna Skrzypczak Jacek C Szepietowski Source Type: research
The Effect of Whey Protein Supplements on Acne Vulgaris among Male Adolescents and Young Adults: A Case-Control Study from North of Jordan
CONCLUSION: This case-control study provides evidence of a positive association between whey protein consumption and acne risk.PMID:38633058 | PMC:PMC11022506 | DOI:10.1155/2024/2158229 (Source: Dermatology Research and Practice)
Source: Dermatology Research and Practice - April 18, 2024 Category: Dermatology Authors: Jihan Muhaidat Almutazballlah Qablan Faris Gharaibeh Ghaith H Albataineh Nour Abdo Diala Alshiyab Firas Al-Qarqaz Source Type: research
Unveiling the Nuances of Adult Female Acne: A Comprehensive Exploration of Epidemiology, Treatment Modalities, Dermocosmetics, and the Menopausal Influence
(Source: International Journal of Womens Health)
Source: International Journal of Womens Health - April 18, 2024 Category: OBGYN Tags: International Journal of Women's Health Source Type: research
Top studies of 2023 relevant to primary care: From the PEER team
CONCLUSION: Research published in 2023 yielded several high-quality articles with topics relevant to primary care, including cardiovascular care, irritable bowel syndrome, care of the elderly, and acne management.PMID:38626998 | DOI:10.46747/cfp.7004245 (Source: Canadian Family Physician Medecin de Famille Canadien)
Source: Canadian Family Physician Medecin de Famille Canadien - April 16, 2024 Category: Primary Care Authors: Betsy S Thomas Danielle Perry Samantha S Moe Ricky D Turgeon Jen Potter Émélie Braschi Nicholas Dugr é Jessica E M Kirkwood G Michael Allan Source Type: research
Top studies of 2023 relevant to primary care: From the PEER team
CONCLUSION: Research published in 2023 yielded several high-quality articles with topics relevant to primary care, including cardiovascular care, irritable bowel syndrome, care of the elderly, and acne management.PMID:38626998 | DOI:10.46747/cfp.7004245 (Source: Pain Physician)
Source: Pain Physician - April 16, 2024 Category: Anesthesiology Authors: Betsy S Thomas Danielle Perry Samantha S Moe Ricky D Turgeon Jen Potter Émélie Braschi Nicholas Dugr é Jessica E M Kirkwood G Michael Allan Source Type: research
Top studies of 2023 relevant to primary care: From the PEER team
CONCLUSION: Research published in 2023 yielded several high-quality articles with topics relevant to primary care, including cardiovascular care, irritable bowel syndrome, care of the elderly, and acne management.PMID:38626998 | DOI:10.46747/cfp.7004245 (Source: Canadian Family Physician Medecin de Famille Canadien)
Source: Canadian Family Physician Medecin de Famille Canadien - April 16, 2024 Category: Primary Care Authors: Betsy S Thomas Danielle Perry Samantha S Moe Ricky D Turgeon Jen Potter Émélie Braschi Nicholas Dugr é Jessica E M Kirkwood G Michael Allan Source Type: research
Ruxolitinib Cream 1.5%: A Review in Non-Segmental Vitiligo
AbstractTopical ruxolitinib 1.5% cream (Opzelura®), a Janus kinase (JAK) inhibitor, is the first treatment to be approved in several countries for use in patients aged ≥ 12 years with non-segmental vitiligo. In the identical phase III TRuE-V1 and TRuE-V2 trials, significantly more ruxolitinib cream recipients were able to achieve statistically significant and clinically meaningful facial and total body repigmentation, as well as reductions in vitiligo noticea bility, compared with vehicle recipients. Efficacy was sustained in longer-term analyses to week 104 of treatment. Ruxolitinib 1.5% cream was generally tolerabl...
Source: Drugs - April 16, 2024 Category: Drugs & Pharmacology Source Type: research
