Iberia consensus on strategies to prevent and manage irritation by topical retinoids in facial and trunk acne
CONCLUSIONS: Skin irritation caused by topical retinoids in facial and trunk acne is an expected, mild, and controllable reaction if proper prevention and management guidelines are followed, meaning that it should not be a reason for treatment discontinuation.PMID:38663728 | DOI:10.1016/j.ad.2024.03.032 (Source: Actas Dermo-Sifiliograficas)
Source: Actas Dermo-Sifiliograficas - April 25, 2024 Category: Dermatology Authors: V Aneri A Catarino C Eguren I Hern ández N Merino S Nogu és L Ob ón M Salleras Source Type: research
Molecules, Vol. 29, Pages 1972: Pharmacological Activities of Lonicerae japonicae flos and Its Derivative & mdash; & ldquo;Chrysoeriol & rdquo; in Skin Diseases
Conclusion: The cutaneous route is the best delivery approach to chrysoeriol across the skin barrier. However, toxicity, dosage, and safety assessments of chrysoeriol in a formulation or nanochrysoeriol on the human epidermis for application in skin diseases must be further investigated. (Source: Molecules)
Source: Molecules - April 25, 2024 Category: Chemistry Authors: Siu Kan Law Xiao Xiao Wu Zhou Jiang Christy Wing Sum Tong Wesley Yeuk Lung Chow Dawn Ching Tung Au Tags: Review Source Type: research
Long-term effectiveness and safety of upadacitinib for Japanese patients with moderate-to-severe atopic dermatitis: a real-world clinical study
CONCLUSIONS: Upadacitinib was therapeutically effective and tolerable for moderate-to-severe AD through 48 weeks in real-world clinical practice.PMID:38653561 | DOI:10.1080/09546634.2024.2344591 (Source: Herpes)
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Teppei Hagino Hidehisa Saeki Eita Fujimoto Naoko Kanda Source Type: research
Assessment of the Effect of < em > Rehmannia glutinosa < /em > Leaf Extract in Maintaining Skin Health: A Proof-of-Concept, Double-Blind, Randomized, Placebo-Controlled Clinical Trial
CONCLUSION: RGLE supplementation at a dose of 100 mg/day has provided a clinically relevant decrease in acne severity and improved the skin hydration and quality of life of the participants with acne after 56 days of dose administration.PMID:38651075 | PMC:PMC11034513 | DOI:10.2147/CCID.S448928 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - April 23, 2024 Category: Dermatology Authors: Shalini Srivastava Shu Fen Huang Manjiri S Jagtap Source Type: research
Sophorin mitigate flutamide-induced hepatotoxicity in Wistar rats
In this study,sophorin was used at a dose of 100mg/kg body weight in purified water via oral route for 4 week daily whereas, flutamide was used at a dose of 100mg kg/b.wt for 4 weeks daily in 0.5% carboxy methyl cellulose (CMC) through the oral route for the induction of hepatotoxicity. Flutamide administration leads to enhanced reactive oxygen species (ROS) generation, an imbalance in redox homeostasis and peroxidation of lipid resulted in reduced natural antioxidant level in liver tissue. Our result demonstrated that sophorin significantly abrogate flutamide induced lipid peroxidation, protein carbonyl (PC), and also sig...
Source: Toxicon - April 23, 2024 Category: Toxicology Authors: Rishi Sharma Md Meraj Ansari Manzar Alam Mohammad Fareed Nemat Ali Anas Ahmad Sarwat Sultana Rehan Khan Source Type: research
Long-term effectiveness and safety of upadacitinib for Japanese patients with moderate-to-severe atopic dermatitis: a real-world clinical study
CONCLUSIONS: Upadacitinib was therapeutically effective and tolerable for moderate-to-severe AD through 48 weeks in real-world clinical practice.PMID:38653561 | DOI:10.1080/09546634.2024.2344591 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 23, 2024 Category: Dermatology Authors: Teppei Hagino Hidehisa Saeki Eita Fujimoto Naoko Kanda Source Type: research
Long-term effectiveness and safety of upadacitinib for Japanese patients with moderate-to-severe atopic dermatitis: a real-world clinical study
CONCLUSIONS: Upadacitinib was therapeutically effective and tolerable for moderate-to-severe AD through 48 weeks in real-world clinical practice.PMID:38653561 | DOI:10.1080/09546634.2024.2344591 (Source: Herpes)
Source: Herpes - April 23, 2024 Category: Infectious Diseases Authors: Teppei Hagino Hidehisa Saeki Eita Fujimoto Naoko Kanda Source Type: research
Sophorin mitigate flutamide-induced hepatotoxicity in Wistar rats
In this study,sophorin was used at a dose of 100mg/kg body weight in purified water via oral route for 4 week daily whereas, flutamide was used at a dose of 100mg kg/b.wt for 4 weeks daily in 0.5% carboxy methyl cellulose (CMC) through the oral route for the induction of hepatotoxicity. Flutamide administration leads to enhanced reactive oxygen species (ROS) generation, an imbalance in redox homeostasis and peroxidation of lipid resulted in reduced natural antioxidant level in liver tissue. Our result demonstrated that sophorin significantly abrogate flutamide induced lipid peroxidation, protein carbonyl (PC), and also sig...
Source: Toxicon - April 23, 2024 Category: Toxicology Authors: Rishi Sharma Md Meraj Ansari Manzar Alam Mohammad Fareed Nemat Ali Anas Ahmad Sarwat Sultana Rehan Khan Source Type: research
Assessment of the Effect of < em > Rehmannia glutinosa < /em > Leaf Extract in Maintaining Skin Health: A Proof-of-Concept, Double-Blind, Randomized, Placebo-Controlled Clinical Trial
CONCLUSION: RGLE supplementation at a dose of 100 mg/day has provided a clinically relevant decrease in acne severity and improved the skin hydration and quality of life of the participants with acne after 56 days of dose administration.PMID:38651075 | PMC:PMC11034513 | DOI:10.2147/CCID.S448928 (Source: Clinical, Cosmetic and Investigational Dermatology)
Source: Clinical, Cosmetic and Investigational Dermatology - April 23, 2024 Category: Dermatology Authors: Shalini Srivastava Shu Fen Huang Manjiri S Jagtap Source Type: research
Long-term effectiveness and safety of upadacitinib for Japanese patients with moderate-to-severe atopic dermatitis: a real-world clinical study
CONCLUSIONS: Upadacitinib was therapeutically effective and tolerable for moderate-to-severe AD through 48 weeks in real-world clinical practice.PMID:38653561 | DOI:10.1080/09546634.2024.2344591 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 23, 2024 Category: Dermatology Authors: Teppei Hagino Hidehisa Saeki Eita Fujimoto Naoko Kanda Source Type: research
Sophorin mitigate flutamide-induced hepatotoxicity in Wistar rats
In this study,sophorin was used at a dose of 100mg/kg body weight in purified water via oral route for 4 week daily whereas, flutamide was used at a dose of 100mg kg/b.wt for 4 weeks daily in 0.5% carboxy methyl cellulose (CMC) through the oral route for the induction of hepatotoxicity. Flutamide administration leads to enhanced reactive oxygen species (ROS) generation, an imbalance in redox homeostasis and peroxidation of lipid resulted in reduced natural antioxidant level in liver tissue. Our result demonstrated that sophorin significantly abrogate flutamide induced lipid peroxidation, protein carbonyl (PC), and also sig...
Source: Toxicon - April 23, 2024 Category: Toxicology Authors: Rishi Sharma Md Meraj Ansari Manzar Alam Mohammad Fareed Nemat Ali Anas Ahmad Sarwat Sultana Rehan Khan Source Type: research
Long-term effectiveness and safety of upadacitinib for Japanese patients with moderate-to-severe atopic dermatitis: a real-world clinical study
CONCLUSIONS: Upadacitinib was therapeutically effective and tolerable for moderate-to-severe AD through 48 weeks in real-world clinical practice.PMID:38653561 | DOI:10.1080/09546634.2024.2344591 (Source: Journal of Dermatological Treatment)
Source: Journal of Dermatological Treatment - April 23, 2024 Category: Dermatology Authors: Teppei Hagino Hidehisa Saeki Eita Fujimoto Naoko Kanda Source Type: research
TRPV3 promotes sebocyte inflammation via transcriptional modulating TLR2 in acne
Biochim Biophys Acta Mol Basis Dis. 2024 Apr 20:167195. doi: 10.1016/j.bbadis.2024.167195. Online ahead of print.ABSTRACTAcne is a common chronic inflammatory disease of the pilosebaceous unit. Transient receptor potential vanilloid 3 (TRPV3) is an ion channel that is involved in inflammatory dermatosis development. However, the involvement of TRPV3 in acne-related inflammation remains unclear. Here, we used acne-like mice and human sebocytes to examine the role of TRPV3 in the development of acne. We found that TRPV3 expression increased in the skin lesions of Propionibacterium acnes (P. acnes)-injected acne-like mice and...
Source: Biochimica et Biophysica Acta - April 22, 2024 Category: Biochemistry Authors: Ziyu Wei Meng Gao Yihe Liu Rong Zeng Juan Liu Shuya Sun Siyuan Li Linghan Hu Ruiyu Xiang Ran Mo Zhongya Song Zhiming Chen Dan Bao Di Hua Christos C Zouboulis Yanyan Feng Ji Li Yong Yang Source Type: research
