Antimicrobial resistance in fecal Escherichia coli and Campylobacter spp. from beef cows in western Canada and associations with herd attributes and antimicrobial use.
The objectives of this study were to describe the frequency of antimicrobial resistance (AMR) in Escherichia coli and Campylobacter spp. isolates in fecal samples from beef cow-calf herds and to examine the associations between herd management practices, reported antimicrobial use, and AMR. Baseline prevalence data are needed to evaluate the effectiveness of antimicrobial stewardship programs. A pooled fecal sample, representing 20 cows, was collected from each of 107 herds during pregnancy testing. In the 305 recovered E. coli isolates (maximum 3 per herd), resistance to ≥ 1 antimicrobial was identified in 12 isolates [...
Source: Canadian Journal of Veterinary Research - March 31, 2019 Category: Veterinary Research Authors: Waldner CL, Gow S, Parker S, Campbell JR Tags: Can J Vet Res Source Type: research
Estimation of Multidrug Resistance Variability in the National Antimicrobial Monitoring System
This study examines the variability of a previously identified resistance pattern in Escherichia coli among ampicillin, gentamicin, sulfisoxazole, and tetracycline using samples isolated from chicken during the years 2004 to 2006 and 2008 to 2012. 2007 is excluded because sulfisozaxole resistance was not measured at slaughter that year. To assess variability in this resistance pattern susceptibility/resistance contingency tables were constructed for each of the 15 combinations of the 4 drugs for each of the years. For each table, variability across the years was assessed at the full table multinomial level as a measure of ...
Source: Preventive Veterinary Medicine - March 13, 2019 Category: Veterinary Research Source Type: research
Synthesis, spectroscopic characterizations, enzyme inhibition, molecular docking study and DFT calculations of new Schiff bases of sulfa drugs
Publication date: Available online 5 March 2019Source: Journal of Molecular StructureAuthor(s): Saliha Alyar, Tülin Şen, Cihan Şen, Hamit Alyar, Şevki Adem, Ümmühan Özmen ÖzdemirAbstractNew Schiff bases were synthesized (Z)-4-((4-(diethylamino)benzylidene)amino)-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide (L1) and (Z)-4-((4-(dimethylamino)benzylidene) amino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide (L2) derived from sulfamethoxazole (S1)/sulfisoxazole (S2) and substituted salicylaldehyde. The synthesized compounds were characterized by FT-IR, 1H-13C NMR, LC-MS. We evaluated the effects of compounds on eight ...
Source: Journal of Molecular Structure - March 5, 2019 Category: Molecular Biology Source Type: research
GSE124320 miRNA Expression data from sulfisoxazole-treated breast cancer cell-derived exosome
Contributors : Moon-Chang Baek ; Eun-Ju ImSeries Type : Non-coding RNA profiling by arrayOrganism : Homo sapiens ; synthetic constructSulfisoxazole, a FDA-approved drug, is a promising repositioned drug candidate for the treatement of various cancers. Therefore we analyzed the gene expression by microarray to identified the up-regulated and down-regulated genes after SFX treatment in breast cancer cell-derived exosomes. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - December 25, 2018 Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by array Homo sapiens synthetic construct Source Type: research
In Vitro Study on the Effect of Maraviroc or Dolutegravir on Bilirubin to Albumin Binding
We performed an in vitro evaluation of the effect of maraviroc or dolutegravir on bilirubin to albumin binding. At typical treatment and low albumin concentrations, maraviroc had no impact, while dolutegravir affected bilirubin to albumin binding to an equivalent extent as sulfisoxazole. However in vivo, neither is likely to significantly impact bilirubin to albumin binding because of their low concentrations relative to albumin. (Source: The Pediatric Infectious Disease Journal)
Source: The Pediatric Infectious Disease Journal - August 15, 2018 Category: Infectious Diseases Tags: HIV Reports Source Type: research
GSE117991 Expression data from sulfisoxazole-treated cancer cells
Contributors : Moon-Chang Baek ; Eun-Ju ImSeries Type : Expression profiling by arrayOrganism : Homo sapiensSulfisoxazole, a FDA-approved drug, is a promising repositioned drug candidate for the treatement of various cancers. Therefore we analyzed the gene expression by microarray to identified the up-regulated and down-regulated genes after SFX treatment in both, melanoma and breast cancer cells. (Source: GEO: Gene Expression Omnibus)
Source: GEO: Gene Expression Omnibus - August 2, 2018 Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Synthesis, characterization, antimicrobial activity, carbonic anhydrase enzyme inhibitor effects, and computational studies on new Schiff bases of Sulfa drugs and their Pd(II), Cu(II) complexes
Publication date: 5 November 2018 Source:Journal of Molecular Structure, Volume 1171 Author(s): Saliha Alyar, Cihan Şen, Hamit Alyar, Şevki Adem, Ayse Kalkanci, Ummuhan Ozmen Ozdemir New Schiff bases (E)N-(3,4-dimethylisoxazol-5-yl)-4-((2-hydroxy-3-methoxybenzylidene) amino)benzenesulfonamide (Ll), (E)N-(3,4-dimethylisoxazol-5-yl)-4-((2-hydroxy-4-methoxybenzylidene)amino)benzenesulfonamide (L2) and (E)-4-((4-methoxy-2-hydroxybenzylidene)amino)N-(5-methylisoxazol-3-yl)benzene sulfonamide (L3) derived from sulfamethoxazole (S1)/sulfisoxazole (S2) and substituted salicylaldehydes and their Pd (II), Cu (II) complexes...
Source: Journal of Molecular Structure - June 12, 2018 Category: Molecular Biology Source Type: research
Passive surveillance of antimicrobial resistance in Salmonella and Escherichia coli isolates from Ontario livestock, 2007-2015.
Abstract
Clinical isolates are important to antimicrobial resistance surveillance efforts because clinically ill animals are the direct targets of antimicrobial treatments. Thus, clinical data may provide a surveillance tool for identifying emerging resistance threats. The purpose of this study was to describe resistance trends in Escherichia coli and Salmonella spp. from clinically ill animals over time and evaluate the utility of these laboratory data as a passive surveillance tool. Susceptibility results of isolates from chickens, swine, and cattle recovered between 2007 and 2015 at a major veterinary d...
Source: The Canadian Veterinary Journal - June 1, 2018 Category: Veterinary Research Authors: Kadykalo SV, Anderson MEC, Alsop JE Tags: Can Vet J Source Type: research
The Role of Mobile Genetic Elements in the Spread of Antimicrobial-Resistant Escherichia coli From Chickens to Humans in Small-Scale Production Poultry Operations in Rural Ecuador.
Abstract
Small-scale production poultry operations are increasingly common worldwide. To investigate how these operations influence antimicrobial resistance and mobile genetic elements (MGEs), Escherichia coli isolates were sampled from small-scale production birds (raised in confined spaces with antibiotics in feed), household birds (no movement constraints; fed on scraps), and humans associated with these birds in rural Ecuador (2010-2012). Isolates were screened for genes associated with MGEs as well as phenotypic resistance to 12 antibiotics. Isolates from small-scale production birds had significantly...
Source: Am J Epidemiol - March 1, 2018 Category: Epidemiology Authors: Moser KA, Zhang L, Spicknall I, Braykov NP, Levy K, Marrs CF, Foxman B, Trueba G, Cevallos W, Goldstick J, Trostle J, Eisenberg JNS Tags: Am J Epidemiol Source Type: research
Site-specific binding of a water molecule to the sulfa drugs sulfamethoxazole and sulfisoxazole: A laser-desorption isomer-specific UV and IR study
Phys. Chem. Chem. Phys., 2018, Accepted Manuscript DOI: 10.1039/C7CP08579F, PaperThomas Uhlemann, Sebastian Seidel, Christian W Mueller To determine the preferred water molecule binding sites of the polybasic sulfa drugs sulfamethoxazole (SMX) and sulfisoxazole (SIX), we have studied their monomers and monohydrated complexes through laser-desorption conformer-specific UV... The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Phys. Chem. Chem. Phys. latest articles)
Source: RSC - Phys. Chem. Chem. Phys. latest articles - February 13, 2018 Category: Chemistry Authors: Thomas Uhlemann Source Type: research
Novelty aqueous two-phase extraction system based on ionic liquid for determination of sulfonamides in blood coupled with high-performance liquid chromatography
Publication date: January 2018 Source:Microchemical Journal, Volume 136 Author(s): Wei Yu, Kai Li, Zhongling Liu, Hanqi Zhang, Xiangqun Jin Ionic liquid/anionic surfactant aqueous two-phase system was developed and applied for the extraction of sulfonamides in blood. High-performance liquid chromatography was applied to the determination of the analytes. The blood sample was centrifuged and added to sodium dodecyl sulfate (SDS), ionic liquid 1-Hexyl-3-MethylImidazolium Chloride([C6MIM] Cl), K2HPO4. After the resulting mixture was ultrasonically shaken and centrifuged, the aqueous two phase system was formed and anal...
Source: Microchemical Journal - September 28, 2017 Category: Chemistry Source Type: research
The Role of Mobile Genetic Elements in the Spread of Antimicrobial-Resistant Escherichia coli From Chickens to Humans in Small-Scale Production Poultry Operations in Rural Ecuador
AbstractSmall-scale production poultry operations are increasingly common worldwide. To investigate how these operations influence antimicrobial resistance and mobile genetic elements (MGEs),Escherichia coli isolates were sampled from small-scale production birds (raised in confined spaces with antibiotics in feed), household birds (no movement constraints; fed on scraps), and humans associated with these birds in rural Ecuador (2010 –2012). Isolates were screened for genes associated with MGEs as well as phenotypic resistance to 12 antibiotics. Isolates from small-scale production birds had significantly elevated odds o...
Source: American Journal of Epidemiology - August 17, 2017 Category: Epidemiology Source Type: research
Enhanced degradation performance of sulfisoxazole using peroxymonosulfate activated by copper-cobalt oxides in aqueous solution: Kinetic study and products identification
In this study, an efficacious heterogeneous copper-cobalt catalyst (Cu0.39Co1.01O4.57) was synthesized by a simple coprecipitation method to activate peroxymonosulfate (PMS) to degrade sulfisoxazole (SIX). On the surface of this catalyst, active sites like Co2+, Co3+ and Cu2+ were found. In the optimal condition, SIX could be completely degraded in 30min at ambient temperature, pH=7 and by 1.87mM PMS and 0.1gL−1 Cu0.39Co1.01O4.57. The addition of this catalyst also enhanced the degradation of other 5 sulfonamides (SAs). The possible catalytic mechanism was discussed that Co2+ first formed Co(OH)+, then it activated PMS t...
Source: Chemical Engineering Journal - August 2, 2017 Category: Chemistry Source Type: research
Surveillance of antimicrobial resistance among Escherichia coli from chicken and swine, China, 2008 –2015
The objective of this study was to investigate the antimicrobial resistance trend in Escherichia coli from food animals in China. During 2008–2015, a total of 15,130 E. coli were isolated from chicken and swine from seven provinces. The susceptibilities of these isolates to nine classes of antimicrobial agents were determined using broth microdilution susceptibility method. The findings of this study include: (1) multi-drug resistance was highly prevalent in E. coli; (2) these E. coli isolates showed high resistant rate (>80%) to several old drugs, including ampicillin, tetracycline and sulfisoxazole; (3) increasi...
Source: Veterinary Microbiology - March 1, 2017 Category: Veterinary Research Source Type: research
Surveillance of Antimicrobial Resistance among Escherichia coli from Chicken and Swine, China, 2008-2015
The objective of this study was to investigate the antimicrobial resistance trend in Escherichia coli from food animals in China. During 2008-2015, a total of 15,130 E. coli were isolated from chicken and swine from seven provinces. The susceptibilities of these isolates to nine classes of antimicrobial agents were determined using broth microdilution susceptibility method. The findings of this study include: (1) multi-drug resistance was highly prevalent in E. coli; (2) these E. coli isolates showed high resistant rate (>80%) to several old drugs, including ampicillin, tetracycline and sulfisoxazole; (3) increasing...
Source: Veterinary Microbiology - February 20, 2017 Category: Veterinary Research Source Type: research
