Perioperative beta-blockers for preventing surgery-related mortality and morbidity in adults undergoing cardiac surgery.
CONCLUSIONS: We found no evidence of a difference in early all-cause mortality, myocardial infarction, cerebrovascular events, hypotension and bradycardia. However, there may be a reduction in atrial fibrillation and ventricular arrhythmias when beta-blockers are used. A larger sample size is likely to increase the certainty of this evidence. Four studies awaiting classification may alter the conclusions of this review.
PMID: 31544227 [PubMed - as supplied by publisher] (Source: Cochrane Database of Systematic Reviews)
Source: Cochrane Database of Systematic Reviews - September 22, 2019 Category: General Medicine Authors: Blessberger H, Lewis SR, Pritchard MW, Fawcett LJ, Domanovits H, Schlager O, Wildner B, Kammler J, Steinwender C Tags: Cochrane Database Syst Rev Source Type: research
Choice of anti-hypertensive treatment in HELLP syndrome at ehu Oran
ConclusionThe management of hypertension was done according to a codified protocol with molecules available in each Maghreb establishment; it requires deep involvement of the paramedical staff. (Source: Archives of Cardiovascular Diseases Supplements)
Source: Archives of Cardiovascular Diseases Supplements - July 24, 2019 Category: Cardiology Source Type: research
Analysis of beta-blocker bioconcentration in brown planaria (Girardia dorotocephala) and its effects on regeneration.
Abstract
Production, distribution, and disposal of pharmaceutical products, including beta-blockers, have become a global issue. Beta-blockers are known to persist in the environment months after their release and may result in the disruption of the homeostatic system in non-target organisms. Here, we study the bioconcentration of three of the most commonly used beta-blockers and their effect on the regeneration of Girardia dorotocephala, a freshwater brown planarian. Acute toxicity tests determined LC50s for acebutolol, metoprolol, and propranolol to be 778 mg/L, 711 mg/L, and 111 mg/L, respectively. The...
Source: Environmental Science and Pollution Research International - July 19, 2019 Category: Environmental Health Authors: AminiTabrizi R, Hassan D, Davis R, Tucker KR Tags: Environ Sci Pollut Res Int Source Type: research
Structural and energetic evolution of fibrinogen toward to the betablocker interactions.
We present a computational analysis coupled with experimental studies, focusing on the binding-interaction between beta-adrenoreceptor blocking agents (acebutolol and propranolol) with fibrinogen protein (E-region). Herein, computational modeling on structural validation and flexibility properties of fibrinogen E-region showed that the E-region interacting residues, which form the funnel-shaped hydrophobic cavity for ligand-binding, can be efficiently modeled. The obtained free energy of binding (FEB) values for the docking complexes, namely acebutolol/fibrinogen E-region and propranolol/fibrinogen E-region, were very clos...
Source: International Journal of Biological Macromolecules - June 28, 2019 Category: Biochemistry Authors: González-Durruthy M, Scanavachi G, Rial R, Liu Z, Cordeiro MNDS, Itri R, Ruso JM Tags: Int J Biol Macromol Source Type: research
Correction to: A case of fatal acebutolol poisoning: an illustration of the potential of molecular networking
The published version of this article unfortunately contained a mistake. In Figure 1 on the molecular network of acebutololol, two molecular structures are not displayed ( “acebutolol glucuronide “and “impurity J”). The Figure is corrected here. (Source: International Journal of Legal Medicine)
Source: International Journal of Legal Medicine - May 23, 2019 Category: Medical Law Source Type: research
Effect of cavitation erosion in the sonochemical exfoliation of activated graphite for electrocatalysis of acebutolol.
This study mainly covered the cavitation erosion in probe sonication and its electrochemical behavior. The activated graphite was exfoliated by the probe sonication wherein the titanium alloy (TA) is used as a probe (micro-tip). The sonication performed in the aqueous solution contains a mixture of sulfuric acid and nitric acid (1:1). The exfoliated graphite (EG) was examined by field emission scanning electron microscope, Raman and X-ray diffraction pattern analysis. The results showed that some TA particles dissolute from the TA micro-tip accompanied with graphite exfoliation. This dissolution experienced from the cavita...
Source: Ultrasonics Sonochemistry - May 20, 2019 Category: Chemistry Authors: Karikalan N, Elavarasan M, Yang TCK Tags: Ultrason Sonochem Source Type: research
Droplet flow-assisted heterogeneous electro-Fenton reactor for degradation of beta-blockers: response surface optimization, and mechanism elucidation.
In this study, we report an effective degradation method for trace level beta-blockers (propranolol and acebutolol) in hospital wastewater using a new droplet flow-assisted heterogeneous electro-Fenton reactor (DFEF) system. Biogenic iron-carbon nanocomposites (RHS/C-x% Fe) as eco-friendly and low-cost heterogeneous Fenton catalysts were synthesized from rice husk via hydrolytic sol-gel routes. Here, we demonstrate the use of natural air as a nebulizing agent for fast and continuous catholyte air saturation and Fenton catalyst transfer to the cathode electrode. The effects of key operational parameters were evaluated and o...
Source: Environmental Science and Pollution Research International - March 11, 2019 Category: Environmental Health Authors: Nsubuga H, Basheer C, Jalilov A, Haider MB, Al-Saadi AA Tags: Environ Sci Pollut Res Int Source Type: research
Nature of intramolecular dynamics in protic ionic glass-former: insight from ambient and high pressure Brillouin spectroscopy
Publication date: Available online 28 February 2019Source: Journal of Molecular LiquidsAuthor(s): M. Pochylski, J. Gapiński, Z. Wojnarowska, M. Paluch, A. PatkowskiAbstractProton conducting materials play an important role in a variety of electrochemical devices. Especially, the class of protic ionic glass-formers with fast water-independent proton transport within the Grotthuss mechanism has been envisioned as promising fuel cell electrolytes. Nevertheless, despite a number of reports on protic ionic glasses the description of proton transport phenomenon in these systems is still incomplete. Herein, we employed the Brill...
Source: Journal of Molecular Liquids - February 28, 2019 Category: Molecular Biology Source Type: research
Dispersive solid-phase extraction using multi-walled carbon nanotubes combined with liquid chromatography–mass spectrometry for the analysis of β-blockers: Experimental and theoretical studies
Publication date: May 2019Source: Microchemical Journal, Volume 146Author(s): Aleksandra Jakubus, Maciej Gromelski, Karolina Jagiello, Tomasz Puzyn, Piotr Stepnowski, Monika PaszkiewiczAbstractThis manuscript presents a dispersive solid phase extraction (dSPE) method combined with liquid chromatography mass spectrometry (LC-MS/MS) to simultaneous determination and quantification of six β-blockers in environmental water samples. The proposed method is based on a multi-walled carbon nanotubes (MWCNTs) as a sorbent, because of their remarkable sorption capacity. Crucial parameters which may affect extraction efficiency such ...
Source: Microchemical Journal - January 15, 2019 Category: Chemistry Source Type: research
Migraine Headache Prophylaxis.
Abstract
Migraines impose significant health and financial burdens. Approximately 38% of patients with episodic migraines would benefit from preventive therapy, but less than 13% take prophylactic medications. Preventive medication therapy reduces migraine frequency, severity, and headache-related distress. Preventive therapy may also improve quality of life and prevent the progression to chronic migraines. Some indications for preventive therapy include four or more headaches a month, eight or more headache days a month, debilitating headaches, and medication-overuse headaches. Identifying and managing en...
Source: American Family Physician - January 1, 2019 Category: Primary Care Authors: Ha H, Gonzalez A Tags: Am Fam Physician Source Type: research
Simultaneous determination of pindolol, acebutolol and metoprolol in waters by differential-pulse voltammetry using an efficient sensor based on carbon paste electrode modified with amino-functionalized mesostructured silica
Publication date: 15 March 2019Source: Sensors and Actuators B: Chemical, Volume 283Author(s): Mariana Silva, Sonia Morante-Zarcero, Damián Pérez-Quintanilla, Isabel SierraAbstractIn this work, hexagonal mesoporous silica (HMS) and amino-functionalized HMS (HMS-NH2) were prepared and incorporated into carbon paste electrodes (CPEs) to obtain electrochemical sensors for pindolol (Pin), acebutolol (Ace) and metoprolol (Met) determination in waters by voltammetric techniques. The materials were characterized and they showed high specific surface area, large pore volume and a quasi-spherical morphology. Firstly, the electroc...
Source: Sensors and Actuators B: Chemical - December 18, 2018 Category: Chemistry Source Type: research
LC and LC–MS/MS studies for the identification and characterization of degradation products of acebutolol
Publication date: Available online 15 March 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): Uday Rakibe, Ravi Tiwari, Anand Mahajan, Vipul Rane, Pravin WakteAbstractThe aim of the present investigation was to demonstrate an approach involving use of liquid chromatography (LC) and liquid chromatography-mass spectrometry (LC–MS) to separate, identify and characterize very small quantities of degradation products (DPs) of acebutolol without their isolation from the reaction mixtures. The drug was subjected to oxidative, hydrolytic, thermal and photolytic stress conditions as per International Conference on Harmoniz...
Source: Journal of Pharmaceutical Analysis - July 10, 2018 Category: Drugs & Pharmacology Source Type: research
LC and LC–MS/MS studies for the identification and characterization of degradation products of acebutalol
Publication date: Available online 15 March 2018Source: Journal of Pharmaceutical AnalysisAuthor(s): Uday Rakibe, Ravi Tiwari, Anand Mahajan, Vipul Rane, Pravin WakteAbstractThe aim of the present investigation was to demonstrate an approach involving use of liquid chromatography (LC) and liquid chromatography-mass spectrometry (LC-MS) analytical techniques to separate, identify and characterize very small quantities of degradation products (DPs) of acebutolol without their isolation from the reaction mixtures. The drug was subjected to oxidative, hydrolytic, thermal and photolytic stress conditions as per International Co...
Source: Journal of Pharmaceutical Analysis - July 5, 2018 Category: Drugs & Pharmacology Source Type: research
LC and LC –MS/MS studies for the identification and characterization of degradation products of acebutalol
Publication date: Available online 15 March 2018 Source:Journal of Pharmaceutical Analysis Author(s): Uday Rakibe, Ravi Tiwari, Anand Mahajan, Vipul Rane, Pravin Wakte The aim of the present investigation was to demonstrate an approach involving use of liquid chromatography (LC) and liquid chromatography-mass spectrometry (LC-MS) analytical techniques to separate, identify and characterize very small quantities of degradation products (DPs) of acebutolol without their isolation from the reaction mixtures. The drug was subjected to oxidative, hydrolytic, thermal and photolytic stress conditions as per International C...
Source: Journal of Pharmaceutical Analysis - March 16, 2018 Category: Drugs & Pharmacology Source Type: research
Whole body physiologically based modelling of β‐blockers in the rat: events in tissues and plasma following an i.v. bolus dose
Conclusions and ImplicationsPBPK modelling is a very powerful tool to aid drug discovery and development of therapeutic agents in animals and humans. However, careful consideration of the assumptions made during the modelling exercise is essential. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - December 1, 2017 Category: Drugs & Pharmacology Authors: S Y A Cheung, T Rodgers, L Aarons, I Gueorguieva, G L Dickinson, S Murby, C Brown, B Collins, M Rowland Tags: RESEARCH PAPER Source Type: research
