Surface sulfuration of antimony oxide enhances the electrochemical determination of acebutolol in biomedical samples
Publication date: Available online 15 May 2021Source: Journal of Electroanalytical ChemistryAuthor(s): Ahmed S. Haidyrah, Natarajan Karikalan, Raj Karthik, Jae-Jin Shim, Chun-Chen Yang, Chelladurai Karuppiah (Source: Journal of Electroanalytical Chemistry)
Source: Journal of Electroanalytical Chemistry - May 16, 2021 Category: Chemistry Source Type: research
Prediction of Plasma Concentrations Using In Silico Modelling and Simulation Approach: Case of Acebutolol
Conclusion Based on the in vitro results combined with in silico simulations using GastroPlusTM, a biowaiver for immediate release acebutolol tablets is justified. Furthermore, computer modelling has shown to be a very intersting tool to prove the bioequivalence for these products.PMID:33675740 | DOI:10.1016/j.pharma.2021.02.004 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - March 6, 2021 Category: Drugs & Pharmacology Authors: Emna Bokri Hajer Felfel Senda Bahri Source Type: research
Prediction of Plasma Concentrations Using In Silico Modelling and Simulation Approach: Case of Acebutolol
Conclusion Based on the in vitro results combined with in silico simulations using GastroPlusTM, a biowaiver for immediate release acebutolol tablets is justified. Furthermore, computer modelling has shown to be a very intersting tool to prove the bioequivalence for these products.PMID:33675740 | DOI:10.1016/j.pharma.2021.02.004 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - March 6, 2021 Category: Drugs & Pharmacology Authors: Emna Bokri Hajer Felfel Senda Bahri Source Type: research
Prediction of Plasma Concentrations Using In Silico Modelling and Simulation Approach: Case of Acebutolol
Conclusion Based on the in vitro results combined with in silico simulations using GastroPlusTM, a biowaiver for immediate release acebutolol tablets is justified. Furthermore, computer modelling has shown to be a very intersting tool to prove the bioequivalence for these products.PMID:33675740 | DOI:10.1016/j.pharma.2021.02.004 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - March 6, 2021 Category: Drugs & Pharmacology Authors: Emna Bokri Hajer Felfel Senda Bahri Source Type: research
Prediction of Plasma Concentrations Using In Silico Modelling and Simulation Approach: Case of Acebutolol
Conclusion Based on the in vitro results combined with in silico simulations using GastroPlusTM, a biowaiver for immediate release acebutolol tablets is justified. Furthermore, computer modelling has shown to be a very intersting tool to prove the bioequivalence for these products.PMID:33675740 | DOI:10.1016/j.pharma.2021.02.004 (Source: Annales Pharmaceutiques Francaises)
Source: Annales Pharmaceutiques Francaises - March 6, 2021 Category: Drugs & Pharmacology Authors: Emna Bokri Hajer Felfel Senda Bahri Source Type: research
The adsorption performance and micro-mechanism of MoS2/montmorillonite composite to atenolol and acebutolol: Adsorption experiments and a novel visual study of interaction.
Abstract
MoS2/montmorillonite (MoS2/Mt) composite was successfully synthesized through a simple hydrothermal method, and its adsorption performance for two emerging contaminants-atenolol (ATE) and acebutolol (ACE) was researched. The batch experiments revealed that the adsorption process can be described by the Pseudo-second order model and Langmuir model, and the adsorption capacity of MoS2/Mt, MoS2 and Mt for ATE were 132.08 mg/g, 60.68 mg/g and 74.23 mg/g, for ACE were 113.82 mg/g, 33.01 mg/g and 36.05 mg/g, respectively. Besides, Fourier-transform infrared spectroscopy (FTIR), BET specific surfac...
Source: Ecotoxicology and Environmental Safety - February 9, 2021 Category: Environmental Health Authors: Shi W, Chu Y, Xia M, Wang F, Fu C Tags: Ecotoxicol Environ Saf Source Type: research
Molecular interactions of acebutolol hydrochloride to human serum albumin: A combined calorimetric, spectroscopic and molecular modelling approach
Publication date: Available online 28 January 2021Source: Materials Today: ProceedingsAuthor(s): Anu Radha, Anju Singh, Lalit Sharma, Kamal Kishor Thakur (Source: Materials Today: Proceedings)
Source: Materials Today: Proceedings - January 29, 2021 Category: Materials Science Source Type: research
Molecules, Vol. 25, Pages 5425: Targeting Beta-Blocker Drug –Drug Interactions with Fibrinogen Blood Plasma Protein: A Computational and Experimental Study
Molecules, Vol. 25, Pages 5425: Targeting Beta-Blocker Drug–Drug Interactions with Fibrinogen Blood Plasma Protein: A Computational and Experimental Study
Molecules doi: 10.3390/molecules25225425
Authors:
Michael González-Durruthy
Riccardo Concu
Laura F. Osmari Vendrame
Ivana Zanella
Juan M. Ruso
M. Natália D.S. Cordeiro
In this work, one of the most prevalent polypharmacology drug–drug interaction events that occurs between two widely used beta-blocker drugs—i.e., acebutolol and propranolol—with the most abundant blood plasma fibrinogen protein was evaluated....
Source: Molecules - November 19, 2020 Category: Chemistry Authors: Michael Gonz ález-Durruthy Riccardo Concu Laura F. Osmari Vendrame Ivana Zanella Juan M. Ruso M. Nat ália D.S. Cordeiro Tags: Article Source Type: research
β-blocker therapy for infantile haemangioma.
Authors: Koh SP, Leadbitter P, Smithers F, Tan ST
Abstract
INTRODUCTION: 15% of proliferating infantile haemangioma (IH) require intervention because of the threat to function or life, ulceration or tissue distortion. Propranolol is the mainstay treatment for problematic proliferating IH. Other β-blockers and angiotensin-converting enzyme (ACE) inhibitors have been explored as alternative treatments.
AREAS COVERED: The demonstration of a haemogenic endothelium origin of IH with a neural crest phenotype and multi-lineage differentiation capacity, regulated by the renin-angiotensin system, underscor...
Source: Expert Review of Clinical Pharmacology - July 15, 2020 Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
N-aryl amides as chemical exchange saturation transfer magnetic resonance imaging contrast agents.
Abstract
Chemical exchange saturation transfer (CEST) MRI has recently emerged as a versatile molecular imaging approach in which diamagnetic compounds can be utilized to generate MRI signal. To expand the scope of CEST MRI applications, herein, we systematically investigated the CEST properties of N-aryl amides with different N-aromatic substitution, revealing their chemical shifts (4.6-5.8 ppm) and exchange rates (up to thousands s -1 ) are favorable to be used as CEST agents as compared to alkyl amide. As the first proof-of-concept study, we used CEST MRI to detect the enzymatic metabolism of the drug a...
Source: Chemistry - July 7, 2020 Category: Chemistry Authors: Cai X, Zhang J, Lu J, Yi L, Han Z, Zhang S, Yang X, Liu G Tags: Chemistry Source Type: research
Enantiospecific behaviour of chiral drugs in soil.
Abstract
The importance of stereochemistry on the behaviour and effects of chiral pharmaceutical and illicit drugs in amended agricultural soils has been over looked to date. Therefore, this study was aimed at investigating the enantiospecific behaviour of a chemically diverse range of chiral drugs including naproxen, ibuprofen, salbutamol, bisoprolol, metoprolol, propranolol, acebutolol, atenolol, chlorpheniramine, amphetamine, fluoxetine and citalopram in soil microcosms. Considerable changes of the enantiomeric composition of ibuprofen, naproxen, atenolol, acebutolol and amphetamine were observed within...
Source: Environmental Pollution - May 25, 2020 Category: Environmental Health Authors: Bertin S, Yates K, Petrie B Tags: Environ Pollut Source Type: research
Drugs for Hypertension
Date: May 18, 2020
Issue #:
1598Summary:
Drugs available for treatment of chronic hypertension
and their dosages, adverse effects, and costs are
listed in the tables. Treatment
of hypertensive urgencies and emergencies is not
discussed here. (Source: The Medical Letter)
Source: The Medical Letter - April 29, 2020 Category: Drugs & Pharmacology Authors: admin Tags: Accupril Accuretic ACE inhibitors Acebutolol Adalat Aldactone aliskiren Altace Amiloride Amlodipine ARBs Atacand Atenolol Avalide Avapro azilsartan benazapril Benicar Beta blockers Betaxolol Bisoprolol Bumetanide Source Type: research
Chiral separation of beta-blockers by high-performance liquid chromatography and determination of bisoprolol enantiomers in surface waters.
Abstract
Beta-blockers are chiral compounds with enantiomers that have different bioactivity, which means that while one is active, the other can be inactive or even harmful. Due to their high consumption and incomplete degradation in waste water, they may reach surface waters and affect aquatic organisms. To address this issue we developed a chromatographic method suitable for determining beta-blocker enantiomers in surface waters. It was tested on five beta-blockers (acebutolol, atenolol, bisoprolol, labetalol and metoprolol) and validated on bisoprolol enantiomers. Good enantioseparation of all analysed...
Source: Arhiv za Higijenu Rada i Toksikologiju - February 29, 2020 Category: Occupational Health Authors: Pocrnić M, Ansorge M, Dovhunová M, Habinovec I, Tesařová E, Galić N Tags: Arh Hig Rada Toksikol Source Type: research
Stereoselective cell uptake of adrenergic agonists and antagonists by organic cation transporters.
Abstract
Stereoselectivity is well described for receptor binding and enzyme catalysis, but so far has only been scarcely investigated in carrier-mediated membrane transport. We thus studied transport kinetics of racemic (anti)adrenergic drugs by the organic cation transporters OCT1 (wild-type and allelic variants), OCT2, OCT3, MATE1, and MATE2-K with a focus on stereospecificity. OCT1 showed stereoselective uptake with up to 2-fold higher vmax over their corresponding counterpart enantiomers for (R,R)-fenoterol, (R,R)-formoterol, (S)-salbutamol, (S)-acebutolol, and (S)-atenolol. Orciprenaline and etilefri...
Source: Biochemical Pharmacology - November 25, 2019 Category: Drugs & Pharmacology Authors: Jensen O, Rafehi M, Tzvetkov MV, Brockmöller J Tags: Biochem Pharmacol Source Type: research
Molecules, Vol. 24, Pages 3664: Graphene Oxide/Polyethylene Glycol-Stick for Thin Film Microextraction of β-Blockers from Human Oral Fluid by Liquid Chromatography-Tandem Mass Spectrometry
Abdel-Rehim
A wooden stick coated with a novel graphene-based nanocomposite (Graphene oxide/polyethylene glycol (GO/PEG)) is introduced and investigated for its efficacy in solid phase microextraction techniques. The GO/PEG-stick was prepared and subsequently applied for the extraction of β-blockers, acebutolol, and metoprolol in human oral fluid samples, which were subsequently detected by liquid chromatography tandem mass spectrometry (LC-MS/MS). Experimental parameters affecting the extraction protocol including sample pH, extraction time, desorption time, appropriate desorption solvent, and salt additi...
Source: Molecules - October 10, 2019 Category: Chemistry Authors: Hanieh Karimiyan Mohammad Reza Hadjmohammadi Karthik Laxman Kunjali Mohammad Mahdi Moein Joydeep Dutta Mohamed Abdel-Rehim Tags: Article Source Type: research
