Further exploration of the collision ‐induced dissociation of select beta blockers: Acebutolol, atenolol, bisoprolol, carteolol, and labetalol
AbstractBeta blockers are a class of drugs commonly used to treat heart-related diseases; they are also regulated under the World Anti-Doping Agency. Tandem mass spectrometry is often used in the pharmaceutical industry, clinical analysis laboratory, and antidoping laboratory for detection and characterization of drugs and their metabolites. A deeper chemical understanding of dissociation pathways may eventually lead to an improved ability to predict tandem mass spectra of compounds based strictly on their chemical structure (or vice versa), which is especially important for characterization of unknowns such as emerging de...
Source: Journal of Mass Spectrometry - November 22, 2023 Category: Chemistry Authors: Matthew J. Carlo,
Amanda L. Patrick Tags: RESEARCH ARTICLE Source Type: research
Estimation of time since death using cardiac troponin I in case of death due to asphyxia and cardiotoxicity of acebutolol
The objective of this study was to investigate the degradation pattern of cardiac troponin I in rats in vivo, and to determine whether the pattern was dependent on the cause of death, for the purpose of estimating the postmortem interval. The rats were categorized into three distinct groups depending on the factors leading to their demise: the control group, the group experiencing acebutolol-induced cardiotoxicity, and the group affected by asphyxia. The analysis encompassed the isolation and segregation of the protein, subsequently employing Western blotting as a means of visualizing the results. The results revealed a di...
Source: Forensic Science, Medicine, and Pathology - October 7, 2023 Category: Forensic Medicine Source Type: research
Reusable passive sampler with carbon nanotubes for monitoring contaminants in wastewater: Application, regeneration and reuse
In this study, carbon nanotubes (CNTs) were successfully applied, regenerated, and reused as a sorbent in passive samplers for monitoring contaminants in treated and untreated wastewater at three wastewater treatment plants (WWTPs) located in different urbanization areas in northern Poland. Three cycles of chemical and thermal regeneration of used sorbents were performed. It was shown that it is possible to regenerate CNTs a minimum of three times and reuse them in passive samplers while maintaining the desired sorption properties. The obtained results confirm that the CNTs are perfectly in line with the main principles of...
Source: Chemosphere - May 6, 2023 Category: Chemistry Authors: Klaudia Godlewska Monika Paszkiewicz Source Type: research
Reusable passive sampler with carbon nanotubes for monitoring contaminants in wastewater: Application, regeneration and reuse
In this study, carbon nanotubes (CNTs) were successfully applied, regenerated, and reused as a sorbent in passive samplers for monitoring contaminants in treated and untreated wastewater at three wastewater treatment plants (WWTPs) located in different urbanization areas in northern Poland. Three cycles of chemical and thermal regeneration of used sorbents were performed. It was shown that it is possible to regenerate CNTs a minimum of three times and reuse them in passive samplers while maintaining the desired sorption properties. The obtained results confirm that the CNTs are perfectly in line with the main principles of...
Source: Chemosphere - May 6, 2023 Category: Chemistry Authors: Klaudia Godlewska Monika Paszkiewicz Source Type: research
Reusable passive sampler with carbon nanotubes for monitoring contaminants in wastewater: Application, regeneration and reuse
In this study, carbon nanotubes (CNTs) were successfully applied, regenerated, and reused as a sorbent in passive samplers for monitoring contaminants in treated and untreated wastewater at three wastewater treatment plants (WWTPs) located in different urbanization areas in northern Poland. Three cycles of chemical and thermal regeneration of used sorbents were performed. It was shown that it is possible to regenerate CNTs a minimum of three times and reuse them in passive samplers while maintaining the desired sorption properties. The obtained results confirm that the CNTs are perfectly in line with the main principles of...
Source: Chemosphere - May 6, 2023 Category: Chemistry Authors: Klaudia Godlewska Monika Paszkiewicz Source Type: research
Beta-blocker carteolol and oxprenolol produce cutaneous analgesia in response to needle pinpricks in the rat
CONCLUSIONS: Oxprenolol and carteolol had greater potencies and longer durations of cutaneous analgesia than butaxamine, metoprolol, and acebutolol. Oxprenolol produced a similar duration of action when compared to bupivacaine, while carteolol had a greater duration of action than bupivacaine. Cutaneous analgesia of oxprenolol (or carteolol) plus adrenaline was greater than that of bupivacaine plus adrenaline.PMID:36403147 | DOI:10.1080/01616412.2022.2148511 (Source: Neurological Research)
Source: Neurological Research - November 20, 2022 Category: Neurology Authors: An-Kuo Chou Yu-Wen Chen Source Type: research
Photodegradation of acebutolol in natural waters: Important roles of carbonate radical and hydroxyl radical
In this study, the photodegradation of ACE in river water and synthetic waters were investigated under simulated sunlight irradiation. The results demonstrated that ACE photodegradation rate in river water was 3.2 times higher than that in pure water. Then the influences of HCO3-, NO3- and DOM on ACE photolysis were investigated under their concentrations similar with the ones in river water. ACE photodegradation was significantly enhanced in the presence of HCO3- alone, and the scavenging experiments and the electron paramagnetic resonance experiments together proved that HCO3- could be oxidized by triplet-excited state o...
Source: Chemosphere - November 27, 2021 Category: Chemistry Authors: Zimi Ye Zhongyu Guo Jieqiong Wang Lilan Zhang Yuchen Guo Chihiro Yoshimura Junfeng Niu Source Type: research
Photodegradation of acebutolol in natural waters: Important roles of carbonate radical and hydroxyl radical
In this study, the photodegradation of ACE in river water and synthetic waters were investigated under simulated sunlight irradiation. The results demonstrated that ACE photodegradation rate in river water was 3.2 times higher than that in pure water. Then the influences of HCO3-, NO3- and DOM on ACE photolysis were investigated under their concentrations similar with the ones in river water. ACE photodegradation was significantly enhanced in the presence of HCO3- alone, and the scavenging experiments and the electron paramagnetic resonance experiments together proved that HCO3- could be oxidized by triplet-excited state o...
Source: Chemosphere - November 27, 2021 Category: Chemistry Authors: Zimi Ye Zhongyu Guo Jieqiong Wang Lilan Zhang Yuchen Guo Chihiro Yoshimura Junfeng Niu Source Type: research
Photodegradation of acebutolol in natural waters: Important roles of carbonate radical and hydroxyl radical
In this study, the photodegradation of ACE in river water and synthetic waters were investigated under simulated sunlight irradiation. The results demonstrated that ACE photodegradation rate in river water was 3.2 times higher than that in pure water. Then the influences of HCO3-, NO3- and DOM on ACE photolysis were investigated under their concentrations similar with the ones in river water. ACE photodegradation was significantly enhanced in the presence of HCO3- alone, and the scavenging experiments and the electron paramagnetic resonance experiments together proved that HCO3- could be oxidized by triplet-excited state o...
Source: Chemosphere - November 27, 2021 Category: Chemistry Authors: Zimi Ye Zhongyu Guo Jieqiong Wang Lilan Zhang Yuchen Guo Chihiro Yoshimura Junfeng Niu Source Type: research
Photodegradation of acebutolol in natural waters: Important roles of carbonate radical and hydroxyl radical
In this study, the photodegradation of ACE in river water and synthetic waters were investigated under simulated sunlight irradiation. The results demonstrated that ACE photodegradation rate in river water was 3.2 times higher than that in pure water. Then the influences of HCO3-, NO3- and DOM on ACE photolysis were investigated under their concentrations similar with the ones in river water. ACE photodegradation was significantly enhanced in the presence of HCO3- alone, and the scavenging experiments and the electron paramagnetic resonance experiments together proved that HCO3- could be oxidized by triplet-excited state o...
Source: Chemosphere - November 27, 2021 Category: Chemistry Authors: Zimi Ye Zhongyu Guo Jieqiong Wang Lilan Zhang Yuchen Guo Chihiro Yoshimura Junfeng Niu Source Type: research
A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview
This article focuses on clinically relevant drug interactions of β-blockers with commonly prescribed medications. In addition to pharmacokinetics and pharmacodynamics of the drug interactions, recommendations for clinical practice are highlighted. The prescribers and the pharmacists are needed to be aware of the drugs interacting with β-blockers to prevent possible adverse drug interactions.PMID:34182907 | DOI:10.2174/1389200222666210614112529 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 29, 2021 Category: Drugs & Pharmacology Authors: Naina Mohamed Pakkir Maideen Balasubramanian Rajkapoor Sudha Muthusamy Sambathkumar Ramanathan Ananda Thangadurai Subramaniam Abdussalam A Sughir Source Type: research
A Review on Pharmacokinetic and Pharmacodynamic Drug Interactions of Adrenergic β-blockers with Clinically Relevant Drugs-An Overview
This article focuses on clinically relevant drug interactions of β-blockers with commonly prescribed medications. In addition to pharmacokinetics and pharmacodynamics of the drug interactions, recommendations for clinical practice are highlighted. The prescribers and the pharmacists are needed to be aware of the drugs interacting with β-blockers to prevent possible adverse drug interactions.PMID:34182907 | DOI:10.2174/1389200222666210614112529 (Source: Current Drug Metabolism)
Source: Current Drug Metabolism - June 29, 2021 Category: Drugs & Pharmacology Authors: Naina Mohamed Pakkir Maideen Balasubramanian Rajkapoor Sudha Muthusamy Sambathkumar Ramanathan Ananda Thangadurai Subramaniam Abdussalam A Sughir Source Type: research
