Propranolol therapy for infantile hemangioma.
CONCLUSIONS: Although large-scale randomized controlled trials must be conducted in order to further evaluate the safety and the possible role of propranolol in the treatment of IH, the reviewed literature suggests that propranolol carries promise as a potential replacement for corticosteroids as first-line therapy or as a part of a multimodal approach.
PMID: 23680605 [PubMed - in process] (Source: Indian Pediatrics)
Source: Indian Pediatrics - March 8, 2013 Category: Pediatrics Authors: Gunturi N, Ramgopal S, Balagopal S, Scott JX Tags: Indian Pediatr Source Type: research
Simple and sensitive liquid chromatography-tandem mass spectrometry methods for quantification of tadalafil in rat plasma: application to pharmacokinetic study in rats.
Abstract
A simple and sensitive liquid chromatography-tandem mass spectrometry method was developed and validated in rat plasma for quantification of tadalafil, a novel therapeutic agent for erectile dysfunction. Tadalafil and acebutolol (internal standard) were extracted by liquid-liquid extraction with tert-butyl methyl ether. The chromatographic separation was performed on a reverse phase C(18) column with a mobile phase consisting of 0.1 % formic acid and acetonitrile (45:55, v/v) at a flow rate of 0.3 mL/min. The protonated analyte was quantitated by multiple reaction monitoring with a Waters Quattr...
Source: Archives of Pharmacal Research - February 23, 2013 Category: Drugs & Pharmacology Authors: Lee JH, Oh JH, Lee YJ Tags: Arch Pharm Res Source Type: research
Voltammetry coupled to mass spectrometry in the presence of isotope (18)O labeled water for the prediction of oxidative transformation pathways of activated aromatic ethers: Acebutolol.
We examined herein the case of the electrochemical hydrolysis of activated aromatic ether. Acebutolol (β-blockers) was selected herein as model of activated aromatic ether, and its electrochemical oxidation was examined in both the presence and absence of isotope (18)O labeled water. To elucidate electrochemical hydrolysis pathway reaction: O-dealkylation or O-dealkoxylation, our approach was used to prove its applicability. The electrochemical oxidation mechanism was then elucidated showing an O-dealkoxylation reaction. In addition, density functional theory (DFT) calculations fully support the experimental conclusions.
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Source: Analytica Chimica Acta - January 25, 2013 Category: Chemistry Authors: Bussy U, Tea I, Ferchaud-Roucher V, Krempf M, Silvestre V, Galland N, Jacquemin D, Andresen-Bergström M, Jurva U, Boujtita M Tags: Anal Chim Acta Source Type: research
Biophysical characterization of the drugs-membrane interaction: the case of propranolol and acebutolol.
Abstract
The interaction of propranolol and acebutolol with biological membranes was assessed in the present work by using a range of biophysical techniques and liposomes, as membrane mimetic models. In order to mimic in vivo conditions, liposomes were made of zwitterionic phosphatidylcholines and experiments were performed at physiologic pH and at various membrane physical states (gel, ripple and fluid phases). Fluorescence techniques were used to study the partition coefficient of β-blockers, the influence of drugs on membrane fluidity and the drugs-membrane binding. Moreover, small and wide angle X-ray...
Source: European Journal of Pharmaceutics and Biopharmaceutics - January 2, 2013 Category: Drugs & Pharmacology Authors: Pereira-Leite C, Carneiro C, Soares JX, Afonso C, Nunes C, Lúcio M, Reis S Tags: Eur J Pharm Biopharm Source Type: research
