iTRAQ-based proteomics and in vitro experiments reveals essential roles of ACE and AP-N in the renin-angiotensin system-mediated congenital ureteropelvic junction obstruction.
CONCLUSION: Suppression of ACE and AP-N expression mediates congenital UPJO pathogenesis by repressing renal tubular epithelial proliferation, promoting ROS production, and enhancing inflammatory factor expression. PMID: 32416091 [PubMed - as supplied by publisher] (Source: Experimental Cell Research)
Source: Experimental Cell Research - May 13, 2020 Category: Cytology Authors: Liu R, Zhang W, Luo M, Qin X, Yang F, Wei Q Tags: Exp Cell Res Source Type: research
Drugs for Hypertension
Date: May 18, 2020 Issue #: 1598Summary: Drugs available for treatment of chronic hypertension and their dosages, adverse effects, and costs are listed in the tables. Treatment of hypertensive urgencies and emergencies is not discussed here. (Source: The Medical Letter)
Source: The Medical Letter - April 29, 2020 Category: Drugs & Pharmacology Authors: admin Tags: Accupril Accuretic ACE inhibitors Acebutolol Adalat Aldactone aliskiren Altace Amiloride Amlodipine ARBs Atacand Atenolol Avalide Avapro azilsartan benazapril Benicar Beta blockers Betaxolol Bisoprolol Bumetanide Source Type: research
Efficacy of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in the Preventative Treatment of Episodic Migraine in Adults
AbstractPurpose of ReviewSystematic review of angiotensin-converting enzyme inhibitors (ACE inhibitors) and angiotensin receptor blockers (ARB) in the prophylactic treatment of adults with migraine. To identify gaps in research and provide guidance for future clinical trials.Recent FindingsA search was completed using PubMed, MEDLINE, Embase, and the Cochrane Library January 1, 1990 through December 31, 2017. The following are keywords used in the search: migraine, migraine prophylaxis/prevention, renin-angiotensin-aldosterone system, RAAS, ACE inhibitors, angiotensin-converting enzyme inhibitors: quinapril, perindopril, r...
Source: Current Pain and Headache Reports - September 12, 2019 Category: Neurology Source Type: research
Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: Potent inhibition by azelnidipine and manidipine
Publication date: Available online 6 April 2019Source: Chemico-Biological InteractionsAuthor(s): Noriaki Ikemura, Satoshi Yamaori, Chinatsu Kobayashi, Shinobu Kamijo, Norie Murayama, Hiroshi Yamazaki, Shigeru OhmoriAbstractThe inhibitory effects of antihypertensive drugs (dihydropyridine calcium channel blockers, angiotensin II receptor blockers, and angiotensin-converting enzyme inhibitors) on cytochrome P450 2J2 (CYP2J2) activity were examined. Amlodipine, azelnidipine, barnidipine, benidipine, cilnidipine, efonidipine, felodipine, manidipine, nicardipine, nifedipine, nilvadipine, nisoldipine, nitrendipine, telmisartan, ...
Source: Chemico Biological Interactions - April 8, 2019 Category: Biochemistry Source Type: research
Inhibitory effects of antihypertensive drugs on human cytochrome P450 2J2 activity: Potent inhibition by azelnidipine and manidipine.
Abstract The inhibitory effects of antihypertensive drugs (dihydropyridine calcium channel blockers, angiotensin II receptor blockers, and angiotensin-converting enzyme inhibitors) on cytochrome P450 2J2 (CYP2J2) activity were examined. Amlodipine, azelnidipine, barnidipine, benidipine, cilnidipine, efonidipine, felodipine, manidipine, nicardipine, nifedipine, nilvadipine, nisoldipine, nitrendipine, telmisartan, delapril, and quinapril inhibited luciferin-2J2/4F12 O-dealkylase activity of recombinant human CYP2J2 in a concentration-dependent manner (IC50 = 0.116-9.19 μM). Kinetic analyses of the inhibitio...
Source: Chemico-Biological Interactions - April 6, 2019 Category: Molecular Biology Authors: Ikemura N, Yamaori S, Kobayashi C, Kamijo S, Murayama N, Yamazaki H, Ohmori S Tags: Chem Biol Interact Source Type: research
Experimental autoimmune myocarditis in rats and therapeutic histamine H1 - H4 receptor inhibition.
Authors: Stasiak A, Gola J, Kraszewska K, Mussur M, Kobos J, Mazurek U, Stark H, Fogel WA Abstract Myocarditis, a life threatening disease, is still not adequately treated. Histamine plays an important role in physiology and pathophysiology of cardiovascular system. All four histamine receptors (H1R - H4R), are present in the heart. Experimental autoimmune myocarditis (EAM) was used to investigate which histamine receptor had a greater impact on the disease's progression. EAM was evoked in Lewis rats by porcine myosin immunization. Mepyramine, ranitidine and ciproxifan were used to inhibit H1R, H2R and H3R receptor...
Source: Journal of Physiology and Pharmacology - March 23, 2019 Category: Drugs & Pharmacology Tags: J Physiol Pharmacol Source Type: research
Comparative effectiveness of generic and brand-name medication use: A database study of US health insurance claims
ConclusionsIn this study, we observed that use of generics was associated with comparable clinical outcomes to use of brand-name products. These results could help in promoting educational interventions aimed at increasing patient and provider confidence in the ability of generic medicines to manage chronic diseases. (Source: PLoS Medicine)
Source: PLoS Medicine - March 13, 2019 Category: Internal Medicine Authors: Rishi J. Desai Source Type: research
Beneficial effect of combined spironolactone and quinapril treatment on thrombosis and hemostasis in 2K1C hypertensive rats.
Abstract A strong correlation between raised aldosterone levels and increased risk of thrombotic disorders has been provided. Clinical studies have demonstrated the benefits of the addition of the aldosterone receptor antagonist to the standard therapy with angiotensin-converting enzyme inhibitor in the reduction of cardiovascular events in patients. We suggest that the benefits of this dual renin-angiotensin-aldosterone system (RAAS) blockade may be related to the drug's effects on the hemostatic and oxidative balance. Thus, we investigated the effect of combined spironolactone (SPIRO) and quinapril (QUIN) admini...
Source: J Physiol Pharmacol - April 1, 2018 Category: Drugs & Pharmacology Authors: Gromotowicz-Poplawska A, Stankiewicz A, Mikita J, Aleksiejczuk M, Marcinczyk N, Szemraj J, Chabielska E Tags: J Physiol Pharmacol Source Type: research
The effect of antihypertensive treatment on arterial stiffness and serum concentration of selected matrix metalloproteinases.
CONCLUSIONS: In patients with arterial hypertension, beside age and systolic blood pressure, the determinants of arterial stiffness include serum MMP-3 concentration. For drugs compared in the study with the same hypotensive effect obtained, the arterial stiffness reduction effect is not dependent on the drug used. Systolic blood pressure is one of the independent factors responsible for the reduction of arterial stiffness in the course of antihypertensive treatment. PMID: 28721143 [PubMed] (Source: Archives of Medical Science)
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research
The Effect of Combined Treatment with the (Pro)Renin Receptor Blocker HRP and Quinapril in Type 1 Diabetic Rats
Conclusion: The effects of HRP were partially beneficial on diabetic kidney lesions as HRP reduced damage but did not improve tubular damage and failed to reduce ERK(1/2) phosphorylation in rats. The combination of HRP with Quinapril had no additive effects over Quinapril monotherapy on the progression of diabetic nephropathy.Kidney Blood Press Res 2017;42:109 –122 (Source: Kidney and Blood Pressure Research)
Source: Kidney and Blood Pressure Research - March 31, 2017 Category: Urology & Nephrology Source Type: research
Rapid analysis of drug dissolution by paper spray ionization mass spectrometry
Publication date: 20 March 2017 Source:Journal of Pharmaceutical and Biomedical Analysis, Volume 136 Author(s): Yang Liu, Ning Liu, Ya-nan Zhou, Lan Lin, Lan He With a great quantity of solid dosage tested by dissolution technology, developing a rapid and sensitive method to access the content of drug within dissolution media is highly desired by analysts and scientists. Traditionally, dissolution media is not compatible with mass spectrometry since the inorganic salts in the media might damage the mass spectrometer. Here, paper spray ionization mass spectrometry (PSI-MS), one of the ambient mass spectrometry technologies...
Source: Journal of Pharmaceutical and Biomedical Analysis - January 7, 2017 Category: Drugs & Pharmacology Source Type: research
Treatment for hereditary angioedema with normal C1 ‐INH and specific mutations in the F12 gene (HAE‐FXII)
We report our experience treating HAE‐FXII with discontinuation of potential trigger factors and drug therapies. The study included 72 patients with HAE‐FXII. Potential triggers included estrogen‐containing oral contraceptives (eOC), hormonal replacement therapy, or angiotensin‐converting enzyme inhibitors. Drug treatment comprised plasma‐derived C1 inhibitor (pdC1‐INH) for acute swelling attacks and progestins, tranexamic acid, and danazol for the prevention of attacks. Discontinuation of eOC was effective in 25 (89.3%) of 28 women and led to a reduction in the number of attacks (about 90%). After ending hormo...
Source: Allergy - December 1, 2016 Category: Allergy & Immunology Authors: K. Bork, K. Wulff, G. Witzke, J. Hardt Tags: Brief Communication Source Type: research
Treatment of hereditary angioedema with normal C1 ‐INH and specific mutations in the F12 gene (HAE‐FXII)
We report our experience treating HAE‐FXII with discontinuation of potential trigger factors and drug therapies. MethodsThe study included 72 patients with HAE‐FXII. Potential triggers included estrogen‐containing oral contraceptives (eOC), hormonal replacement therapy, or angiotensin‐converting enzyme inhibitors. Drug treatment comprised plasma‐derived C1 inhibitor (pdC1‐INH) for acute swelling attacks and progestins, tranexamic acid and danazol for prevention of attacks. ResultsDiscontinuation of eOC was effective in 25/28 (89.3%) of women and led to a reduction of number of attacks (about 90%). After ending ...
Source: Allergy - November 6, 2016 Category: Allergy & Immunology Authors: K. Bork, K. Wulff, G. Witzke, J. Hardt Tags: Brief Communication Source Type: research
Quinapril decreases antifibrinolytic and prooxidative potential of propofol in arterial thrombosis in hypertensive rats
Angiotensin converting enzyme inhibitors and propofol both exert hypotensive action and may affect hemostasis. We investigated the influence of quinapril and propofol on hemodynamics and hemostasis in renal-hypertensive rats with induced arterial thrombosis. Two-kidney, one clip hypertensive rats were treated with quinapril (3.0 mg/kg for 10 days), and then received propofol infusion (15 mg/kg/h) during ongoing arterial thrombosis. The hemodynamic and hemostatic parameters were assayed. Quinapril exerted a hypotensive effect increasing after propofol infusion. Quinapril showed an antithrombotic effect with the platelet adh...
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - May 11, 2016 Category: Biomedical Science Authors: Wojewodzka-Zelezniakowicz, M., Kisiel, W., Kramkowski, K., Gromotowicz-Poplawska, A., Zakrzeska, A., Stankiewicz, A., Kolodziejczyk, P., Szemraj, J., Ladny, J. R., Chabielska, E. Tags: Original Article Source Type: research
Modulation of acute transient exercise-induced hypertension after oral administration of four angiotensin-converting enzyme inhibitors in normotensive horses
In conclusion, administration of PO benazepril at a dose of 0.5 mg/kg modulated physiological hypertension induced by exercise in horses that were otherwise normotensive. (Source: The Veterinary Journal)
Source: The Veterinary Journal - October 23, 2015 Category: Veterinary Research Source Type: research
β-blocker Therapy is Not Associated with Reductions in Angina or Cardiovascular Events After Coronary Artery Bypass Graft Surgery: Insights from the IMAGINE Trial
Conclusions β-blocker therapy after CABG is not associated with reductions in angina or cardiovascular events in low-risk patients with preserved LVEF, and may not be systematically indicated in such patients. (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - June 14, 2015 Category: Cardiology Source Type: research
Application of quantitative NMR for purity determination of standard ACE inhibitors
This study investigated the accuracy of the quantitative NMR method for purity determination of ACE inhibitors reference standards and the discovery of two pairs of new diastereoisomers. Six types of ACE inhibitors, imidapril hydrochloride, benazepril hydrochloride, lisinopril, enalapril maleate, quinapril hydrochloride, and captopril were quantificated and validated for the qNMR method by discussing factors that affect parameters of the qNMR experiment, internal standards, integration, pH-effect, and uncertainty. The results were compared with data obtained by the mass balance method. The study found that maleic acid infl...
Source: Journal of Pharmaceutical and Biomedical Analysis - June 12, 2015 Category: Drugs & Pharmacology Source Type: research
Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril
CONCLUSIONSThe CES1 c.428G > A SNV decreased enalaprilat concentrations likely by reducing the hydrolysis of enalapril, but had no observable effect on the pharmacokinetics of quinapril. This article is protected by copyright. All rights reserved. (Source: British Journal of Clinical Pharmacology)
Source: British Journal of Clinical Pharmacology - April 28, 2015 Category: Drugs & Pharmacology Authors: E. Katriina Tarkiainen, Aleksi Tornio, Mikko T. Holmberg, Terhi Launiainen, Pertti J. Neuvonen, Janne T. Backman, Mikko Niemi Tags: Pharmacogenetics Source Type: research
Design, synthesis and evaluation of novel 2-butyl-4-chloroimidazole derived peptidomimetics as Angiotensin Converting Enzyme (ACE) inhibitors.
Abstract A series of novel 2-butyl-4-chloro-1-methylimidazole derived peptidomimetics were designed, synthesized and evaluated for their Angiotensin Converting Enzyme (ACE) inhibitor activity. 2-Butyl-4-chloro-1-methylimidazole-5-carboxylic acid 2 obtained after oxidation of respective carboxaldehyde 1, was condensed with various amino acid methyl esters 3a-k to give imidazole-amino acid conjugates 4a-k in very good yields. Ester hydrolysis of 4a-k with aqueous LiOH gave the desired peptidomimetics 5a-k. Screening all the new compounds 4a-k and 5a-k using ACE inhibition assay, resulted five compounds 4i, 4k, 5e, 5...
Source: Bioorganic and Medicinal Chemistry - April 16, 2015 Category: Chemistry Authors: Jallapally A, Addla D, Bagul P, Sridhar B, Banerjee SK, Kantevari S Tags: Bioorg Med Chem Source Type: research
Elevated circulating alpha-klotho by angiotensin II receptor blocker losartan is associated with reduction of albuminuria in type 2 diabetic patients
Conclusions: The angiotensin receptor blocker losartan increases circulating α-klotho in T2DM with albuminuria. The clinical significance of this rise in α-klotho associated with losartan intervention deserves further investigation. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Lim, S. C., Liu, J.-J., Subramaniam, T., Sum, C. F. Tags: Original Articles Source Type: research
The effect of indapamide versus hydrochlorothiazide on ventricular and arterial function in patients with hypertension and diabetes: Results of a randomized trial
The objective of this study is to compare the effects of 2 types of diuretics, indapamide and hydrochlorothiazide, added to an angiotensin-converting enzyme inhibitor, on ventricular and arterial functions in patients with hypertension and diabetes.Methods: This is a prospective, randomized, active-controlled, PROBE design study in 56 patients (57 ± 9 years, 52% men) with mild-to-moderate hypertension and type 2 diabetes, with normal ejection fraction, randomized to either indapamide (1.5 mg Slow Release (SR)/day) or hydrochlorothiazide (25 mg/d), added to quinapril (10-40 mg/d). All patients had conventional, tissu...
Source: American Heart Journal - June 16, 2014 Category: Cardiology Authors: Dragos Vinereanu, Raluca Dulgheru, Stefania Magda, Ruxandra Dragoi Galrinho, Maria Florescu, Mircea Cinteza, Christopher Granger, Andrea O. Ciobanu Tags: Trial Designs Source Type: research
Quinapril Treatment Abolishes Diabetes-Associated Atherosclerosis in RAGE/Apolipoprotein E Double Knockout Mice
Source: Atherosclerosis - June 3, 2014 Category: Cardiology Authors: Anna M.D. Watson, Li Jiaze, Dian Samijono, Angelika Bierhaus, Merlin C. Thomas, Karin A.M. Jandeleit-Dahm, Mark Cooper Source Type: research
Effects of renin-angiotensin-aldosterone system inhibitors and beta-blockers on markers of arterial stiffness
Abstract: Antihypertensive agents may, even within the same class, exert variable effects on arterial stiffness variables. Nebivolol could have a better impact than atenolol on arterial stiffness, by increasing the bioavailability of endothelium-derived nitric oxide. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) increase plasma renin activity (enhancing the production of angiotensin II via non-ACE-related pathways) whereas aliskiren does not, potentially affecting central hemodynamics differently. We compared the effects of two renin-angiotensin-aldosterone system (RAAS) inhibito...
Source: Journal of the American Society of Hypertension - October 18, 2013 Category: Cardiology Authors: Charalambos Koumaras, Konstantinos Tziomalos, Eirini Stavrinou, Niki Katsiki, Vasilios G. Athyros, Dimitri P. Mikhailidis, Asterios Karagiannis Tags: Research Articles Source Type: research
Eplerenone enhances cardioprotective effects of standard heart failure therapy through matricellular proteins in hypertensive heart failure
Conclusion:In a hypertensive heart failure rat model, the addition of eplerenone to conventional heart failure therapy further improves cardiac structural and functional parameters, delaying the progression of heart failure. These beneficial effects of eplerenone were associated with normalization of matricellular protein expression. (Source: Journal of Hypertension)
Source: Journal of Hypertension - October 8, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research
Meta‐Analysis of Healing and Prevention of Digital Ulcers in Systemic Sclerosis
ConclusionSmall sample sizes, few comparative trials, and heterogeneity limits the conclusions. The results suggest a role for PDE‐5 inhibitors in the healing of DUs; bosentan and IV iloprost may prevent new DUs. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - August 26, 2013 Category: Rheumatology Authors: Theresa Tingey, Jenny Shu, Joseph Smuczek, Janet Pope Tags: Systemic Sclerosis Source Type: research
Pharmacodynamic Evaluation of 4 Angiotensin‐Converting Enzyme Inhibitors in Healthy Adult Horses
Conclusions and Clinical ImportanceOf the ACE inhibitors tested, oral benazepril (0.5 mg/kg) is the most effective at inhibiting serum ACE activity in healthy horses. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - August 19, 2013 Category: Veterinary Research Authors: T. Afonso, S. Giguère, G. Rapoport, L.J. Berghaus, M.H. Barton, A.E. Coleman Tags: Original Article Source Type: research
Role of the angiotensin converting enzyme 1/angiotensin II/angiotensin receptor 1 axis in interstitial collagenase expression in human carotid atheroma
Conclusions: Our findings suggest that ATR1 blockade alters AII, MMP-1, MMP-8 expression and a marker of elastin degradation in human atheroma, but that the elastin degradation response is not MMP driven. This data contributes to the recognised ability of ATR1 blockade to modify plaque stability.Highlights: (Source: Atherosclerosis)
Source: Atherosclerosis - July 22, 2013 Category: Cardiology Authors: Paula Clancy, Sai-Wang Seto, Simon A. Koblar, Jonathan Golledge Tags: Basic Research - Vascular Biology, Hemostasis, Oxidative Stress Source Type: research
A meta‐analysis of healing and prevention of digital ulcers (DU) in systemic sclerosis (SSc)
Conclusion:Small sample sizes, few comparative trials, and heterogeneity limits the conclusions. The results suggest a role for PDE5 inhibitors in the healing of DU; bosentan and IV iloprost may prevent new DU. © 2013 by the American College of Rheumatology (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - April 1, 2013 Category: Rheumatology Authors: Theresa Tingey, Jenny Shu, Joseph Smuczek, Janet Pope Tags: Original Article Source Type: research