iTRAQ-based proteomics and in vitro experiments reveals essential roles of ACE and AP-N in the renin-angiotensin system-mediated congenital ureteropelvic junction obstruction.

CONCLUSION: Suppression of ACE and AP-N expression mediates congenital UPJO pathogenesis by repressing renal tubular epithelial proliferation, promoting ROS production, and enhancing inflammatory factor expression. PMID: 32416091 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32416091?dopt=Abstract

Source: Experimental Cell Research - May 12, 2020 Category: Cytology Authors: Liu R, Zhang W, Luo M, Qin X, Yang F, Wei Q Tags: Exp Cell Res Source Type: research