Elevated circulating alpha-klotho by angiotensin II receptor blocker losartan is associated with reduction of albuminuria in type 2 diabetic patients
Conclusions:
The angiotensin receptor blocker losartan increases circulating α-klotho in T2DM with albuminuria. The clinical significance of this rise in α-klotho associated with losartan intervention deserves further investigation. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)
Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS - December 12, 2014 Category: Biomedical Science Authors: Lim, S. C., Liu, J.-J., Subramaniam, T., Sum, C. F. Tags: Original Articles Source Type: research
The effect of indapamide versus hydrochlorothiazide on ventricular and arterial function in patients with hypertension and diabetes: Results of a randomized trial
Conclusion: Indapamide was found to improve measures of endothelial and arterial functions and to increase longitudinal left ventricular function compared with hydrochlorothiazide in patients with hypertension and diabetes, after 6 months of treatment. This study suggests that indapamide, a thiazide-like diuretic, has important vascular effects that can improve ventriculoarterial coupling. (Source: American Heart Journal)
Source: American Heart Journal - June 16, 2014 Category: Cardiology Authors: Dragos Vinereanu, Raluca Dulgheru, Stefania Magda, Ruxandra Dragoi Galrinho, Maria Florescu, Mircea Cinteza, Christopher Granger, Andrea O. Ciobanu Tags: Trial Designs Source Type: research
Quinapril Treatment Abolishes Diabetes-Associated Atherosclerosis in RAGE/Apolipoprotein E Double Knockout Mice
(Source: Atherosclerosis)
Source: Atherosclerosis - June 3, 2014 Category: Cardiology Authors: Anna M.D. Watson, Li Jiaze, Dian Samijono, Angelika Bierhaus, Merlin C. Thomas, Karin A.M. Jandeleit-Dahm, Mark Cooper Source Type: research
Effects of renin-angiotensin-aldosterone system inhibitors and beta-blockers on markers of arterial stiffness
Abstract: Antihypertensive agents may, even within the same class, exert variable effects on arterial stiffness variables. Nebivolol could have a better impact than atenolol on arterial stiffness, by increasing the bioavailability of endothelium-derived nitric oxide. Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) increase plasma renin activity (enhancing the production of angiotensin II via non-ACE-related pathways) whereas aliskiren does not, potentially affecting central hemodynamics differently. We compared the effects of two renin-angiotensin-aldosterone system (RAAS) inhibito...
Source: Journal of the American Society of Hypertension - October 18, 2013 Category: Cardiology Authors: Charalambos Koumaras, Konstantinos Tziomalos, Eirini Stavrinou, Niki Katsiki, Vasilios G. Athyros, Dimitri P. Mikhailidis, Asterios Karagiannis Tags: Research Articles Source Type: research
Eplerenone enhances cardioprotective effects of standard heart failure therapy through matricellular proteins in hypertensive heart failure
Conclusion:In a hypertensive heart failure rat model, the addition of eplerenone to conventional heart failure therapy further improves cardiac structural and functional parameters, delaying the progression of heart failure. These beneficial effects of eplerenone were associated with normalization of matricellular protein expression. (Source: Journal of Hypertension)
Source: Journal of Hypertension - October 8, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Therapeutic aspects Source Type: research
Meta‐Analysis of Healing and Prevention of Digital Ulcers in Systemic Sclerosis
ConclusionSmall sample sizes, few comparative trials, and heterogeneity limits the conclusions. The results suggest a role for PDE‐5 inhibitors in the healing of DUs; bosentan and IV iloprost may prevent new DUs. (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - August 26, 2013 Category: Rheumatology Authors: Theresa Tingey, Jenny Shu, Joseph Smuczek, Janet Pope Tags: Systemic Sclerosis Source Type: research
Pharmacodynamic Evaluation of 4 Angiotensin‐Converting Enzyme Inhibitors in Healthy Adult Horses
Conclusions and Clinical ImportanceOf the ACE inhibitors tested, oral benazepril (0.5 mg/kg) is the most effective at inhibiting serum ACE activity in healthy horses. (Source: Journal of Veterinary Internal Medicine)
Source: Journal of Veterinary Internal Medicine - August 19, 2013 Category: Veterinary Research Authors: T. Afonso, S. Giguère, G. Rapoport, L.J. Berghaus, M.H. Barton, A.E. Coleman Tags: Original Article Source Type: research
Role of the angiotensin converting enzyme 1/angiotensin II/angiotensin receptor 1 axis in interstitial collagenase expression in human carotid atheroma
Conclusions: Our findings suggest that ATR1 blockade alters AII, MMP-1, MMP-8 expression and a marker of elastin degradation in human atheroma, but that the elastin degradation response is not MMP driven. This data contributes to the recognised ability of ATR1 blockade to modify plaque stability.Highlights: (Source: Atherosclerosis)
Source: Atherosclerosis - July 22, 2013 Category: Cardiology Authors: Paula Clancy, Sai-Wang Seto, Simon A. Koblar, Jonathan Golledge Tags: Basic Research - Vascular Biology, Hemostasis, Oxidative Stress Source Type: research
A meta‐analysis of healing and prevention of digital ulcers (DU) in systemic sclerosis (SSc)
Conclusion:Small sample sizes, few comparative trials, and heterogeneity limits the conclusions. The results suggest a role for PDE5 inhibitors in the healing of DU; bosentan and IV iloprost may prevent new DU. © 2013 by the American College of Rheumatology (Source: Arthritis Care and Research)
Source: Arthritis Care and Research - April 1, 2013 Category: Rheumatology Authors: Theresa Tingey, Jenny Shu, Joseph Smuczek, Janet Pope Tags: Original Article Source Type: research
