Angiotensin-converting enzyme inhibitors induced angioedema: not always a class effect? A case report and short narrative review

We report here a case of angioedema occurring after ramipril initiation in a patient chronically treated with quinapril. Angioedema subsided spontaneously after ramipril discontinuation and quinapril reintroduction.Discussion and conclusions: Our clinical case suggests that despite similar pharmacodynamic properties, quinapril and ramipril do not have the same potential to generate angioedema. To explain this difference, we suggest a potentiation of the effect of bradykinin at the B2 receptor level by ramipril, which does not occur with quinapril. Consequently, angioedema could not always be a class effect of ACE inhibitors.PMID:34412518 | DOI:10.1080/03007995.2021.1971183
Source: Current Medical Research and Opinion - Category: Research Authors: Source Type: research