Early-onset diabetes mellitus as a presenting feature of Werner's syndrome in an Indian family
CONCLUSION: Our report brings to attention the onset of DM during childhood or early adulthood in patients with Werner's syndrome who typically develop type 2 DM around the age of 30-40 years. Presence of consanguinity among parents, dysmorphic features, and malignancy should prompt consideration of diagnosis of Werner's syndrome.PMID:37815015 | DOI:10.1002/mgg3.2299 (Source: Molecular Medicine)
Source: Molecular Medicine - October 10, 2023 Category: Molecular Biology Authors: Fieke W Hoff Chao Xing Vinaya Simha Anil K Agarwal Xunzhi Zhang Leena Lekkala Madhumati S Vaishnav Frank Vuitch Abhimanyu Garg Source Type: research
Connections between serum Trimethylamine N-Oxide (TMAO), a gut-derived metabolite, and vascular biomarkers evaluating arterial stiffness and subclinical atherosclerosis in children with obesity
ConclusionOur study provides compelling evidence supporting the link between serum TMAO, obesity, and vascular damage in children. These findings highlight the importance of further research to unravel the underlying mechanisms of this connection. (Source: Frontiers in Endocrinology)
Source: Frontiers in Endocrinology - October 2, 2023 Category: Endocrinology Source Type: research
Case Report: Paraneoplastic psoriasis in thymic carcinoma
We report the case of a 36-year-old patient with progressive thymic carcinoma (undifferentiated carcinoma, T3N2M1a) and paraneoplastic psoriasis occurring ten months before the initial diagnosis of the carcinoma. Over the course of the disease, new psoriatic flares heralded relapse or progression of the carcinoma. To our knowledge, this is the first reported case of paraneoplastic psoriasis in thymic carcinoma. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - August 16, 2023 Category: Cancer & Oncology Source Type: research
Clinical features and outcome analysis of type B insulin resistance syndrome: A single-center study in China
CONCLUSIONS: Decreased C3 and IGF-1 levels and normal/decreased TG levels act as striking biochemical features of TBIRS. High-dose glucocorticoid pulse therapy followed by conventional-dose long-term therapy combined with immunosuppressants achieves good clinical efficacy.PMID:37536271 | DOI:10.1210/clinem/dgad461 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - August 3, 2023 Category: Endocrinology Authors: Linlin Zhao Wei Li Lv Liu Lian Duan Linjie Wang Hongbo Yang Huabing Zhang Yuxiu Li Source Type: research
Clinical features and outcome analysis of type B insulin resistance syndrome: A single-center study in China
CONCLUSIONS: Decreased C3 and IGF-1 levels and normal/decreased TG levels act as striking biochemical features of TBIRS. High-dose glucocorticoid pulse therapy followed by conventional-dose long-term therapy combined with immunosuppressants achieves good clinical efficacy.PMID:37536271 | DOI:10.1210/clinem/dgad461 (Source: The Journal of Clinical Endocrinology and Metabolism)
Source: The Journal of Clinical Endocrinology and Metabolism - August 3, 2023 Category: Endocrinology Authors: Linlin Zhao Wei Li Lv Liu Lian Duan Linjie Wang Hongbo Yang Huabing Zhang Yuxiu Li Source Type: research
A promising treatment for spontaneous ovarian hyperstimulation syndrome due to familial partial lipodystrophy: GnRH analogs combined with cyst aspiration
CONCLUSION: Although there are few reports in the literature describing the association between PCOS with FPLD, management of this novel spontaneous OHSS-like condition has not yet been clearly defined. In the case of extremely enlarged multicystic ovaries and severe hyperandrogenemia, GnRH analogs may be considered to prevent ovarian enlargement and reduce hyperandrogenemia, especially when other treatment options are inappropriate.PMID:37491654 | DOI:10.1007/s42000-023-00469-z (Source: Hormones)
Source: Hormones - July 26, 2023 Category: Endocrinology Authors: Asena G ökçay Canpolat Batuhan Aslan Yavuz Emre Şükür Source Type: research
Metastatic adenocarcinoma of the stomach presenting as malignant acanthosis nigricans and tripe palms: a case report
Hong Kong Med J. 2023 Jul 25. doi: 10.12809/hkmj2110002. Online ahead of print.NO ABSTRACTPMID:37489275 | DOI:10.12809/hkmj2110002 (Source: Hong Kong Med J)
Source: Hong Kong Med J - July 25, 2023 Category: General Medicine Authors: C P M Lam M W M Chan Source Type: research
Metastatic adenocarcinoma of the stomach presenting as malignant acanthosis nigricans and tripe palms: a case report
Hong Kong Med J. 2023 Jul 25. doi: 10.12809/hkmj2110002. Online ahead of print.NO ABSTRACTPMID:37489275 | DOI:10.12809/hkmj2110002 (Source: Hong Kong Med J)
Source: Hong Kong Med J - July 25, 2023 Category: General Medicine Authors: C P M Lam M W M Chan Source Type: research
Metastatic adenocarcinoma of the stomach presenting as malignant acanthosis nigricans and tripe palms: a case report
Hong Kong Med J. 2023 Jul 25. doi: 10.12809/hkmj2110002. Online ahead of print.NO ABSTRACTPMID:37489275 | DOI:10.12809/hkmj2110002 (Source: Hong Kong Med J)
Source: Hong Kong Med J - July 25, 2023 Category: General Medicine Authors: C P M Lam M W M Chan Source Type: research
Metastatic adenocarcinoma of the stomach presenting as malignant acanthosis nigricans and tripe palms: a case report
Hong Kong Med J. 2023 Jul 25. doi: 10.12809/hkmj2110002. Online ahead of print.NO ABSTRACTPMID:37489275 | DOI:10.12809/hkmj2110002 (Source: Hong Kong Medical Journal)
Source: Hong Kong Medical Journal - July 25, 2023 Category: General Medicine Authors: C P M Lam M W M Chan Source Type: research
Acanthosis nigricans and hypochondroplasia associated with FGFR3 mutation: A case report
Diego Soto-García, Ana Batalla, Marcos Oro-Ayude, Ángeles FlórezIndian Journal of Dermatology 2023 68(3):333-334 (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - June 30, 2023 Category: Dermatology Authors: Diego Soto-Garc & #237;a Ana Batalla Marcos Oro-Ayude & #193;ngeles Fl & #243;rez Source Type: research
Improved Insulin Secretion Response and Beta-cell Function Correlated with Increased Prolactin Levels After Laparoscopic Sleeve Gastrectomy in Morbidly Obese Patients with Acanthosis Nigricans
ConclusionMorbidly obese patients with AN presented delayed insulin secretion response, impaired insulin secretion, and β-cell dysfunction, which were significantly improved by LSG and might benefit from elevated PRL.Graphical abstract (Source: Obesity Surgery)
Source: Obesity Surgery - June 20, 2023 Category: Surgery Source Type: research
