Acanthosis nigricans – a potentially useful clue to the presence of significant occult disease at autopsy
AbstractA 19-year-old male was found dead in his apartment. At autopsy he was morbidly obese (Body mass index; BMI – 40.5) with multiple areas of velvety pigmented thickening of the skin in folds around the neck, in the axillae, in the inframammary regions, over the anterior waistline and groin regions and over the dorsal aspects of the feet. These had the typical appearance of acanthosis nigricans. Internal e xamination revealed aspiration of gastric contents into the airways. Vitreous humour biochemistry showed markedly elevated levels of both glucose (62.9 mmol/L) and β-hydroxybutyrate (13.54 mmol/L). Death was, th...
Source: Forensic Science, Medicine, and Pathology - April 11, 2024 Category: Forensic Medicine Source Type: research
IJERPH, Vol. 21, Pages 448: Acculturation and Health Status in the Children & rsquo;s Healthy Living Program in the Pacific Region
The objective of this study is to use cross-sectional data to examine the association between proxies of adult/caregiver acculturation/enculturation and child health status (Body Mass Index [BMI], waist circumference [WC], and acanthosis nigricans [AN]) in the U.S.-Affiliated Pacific Islands (USAPI), Alaska, and Hawaiʻi. Study participants were from the Children’s Healthy Living (CHL) Program, an environmental intervention trial and obesity prevalence survey. Anthropometric data from 2–8 year olds and parent/caregiver questionnaires were used in this analysis. The results of this st...
Source: International Journal of Environmental Research and Public Health - April 6, 2024 Category: Environmental Health Authors: Kalanikiekie S. Sparks Marie K. Fialkowski Rica Dela Cruz Andrew Grandinetti Lynne Wilkens Jinan C. Banna Andrea Bersamin Yvette Paulino Tanisha Aflague Patricia Coleman Jonathan Deenik Travis Fleming Rachel Novotny Tags: Article Source Type: research
Oral Malignant Acanthosis Nigricans: An Early Diagnostic Sign for Ovarian Carcinoma: A Case Report
Clin Cosmet Investig Dermatol. 2024 Feb 7;17:359-363. doi: 10.2147/CCID.S447977. eCollection 2024.ABSTRACTAcanthosis nigricans (AN) is a dermatological condition characterised by the symmetrical development of velvety, hyperpigmented plaques predominantly in intertriginous areas such as the axillae, neck, inframammary regions, and groin. The malignant variant of AN is frequently associated with internal malignancies, particularly gastric adenocarcinoma, accounting for 55-61% of cases. Patients exhibiting characteristic skin lesions are commonly initially evaluated in dermatology departments. This case report details a rare...
Source: Clinical, Cosmetic and Investigational Dermatology - February 12, 2024 Category: Dermatology Authors: Yang Liu Xiaoli Wu Siting Chen Wenxia Meng Source Type: research
Efficacy and safety of lasers versus topical medications for acanthosis nigricans and pseudo-acanthosis nigricans treatment: a systematic review
This study followed the PRISMA guidelines for systematic reviews and meta-analyses. Out of 1748 studies, Six clinical trials met our inclusion criteria, with 133 patients. We examined laser therapies, including fractional CO2 laser, 1550-nm erbi um fiber laser, and long-pulsed alexandrite laser, while the topical treatments comprised glycolic acid (GA) peel, retinoic acid peel, trichloroacetic acid (TCA) peel, and tretinoin cream. In two studies, GA peel demonstrated favorable results compared to fractional CO2 laser. Besides, fractional CO 2 laser exhibited efficacy, surpassing TCA peel in AN management. Additionally, a...
Source: Lasers in Medical Science - January 23, 2024 Category: Laser Surgery Source Type: research
Phenotype and predictors of insulin independence in adults presenting with diabetic ketoacidosis: a prospective cohort study
Conclusions/interpretationThe predominant phenotype of adults presenting with a first episode of DKA in Cape Town, South Africa, was that of ketosis-prone type 2 diabetes. These individuals presented with obesity, acanthosis nigricans, negative antibodies and normal C-peptide and could potentially be weaned off insulin at follow-up. Classic type 1 diabetes (lower weight, antibody positivity, low or unrecordable C-peptide levels and long-term insulin dependence) was less common. The simple clinical sign of acanthosis nigricans is a strong predictor of insulin independence at 12 months and 5 years after initial presentation....
Source: Diabetologia - January 19, 2024 Category: Endocrinology Source Type: research
Acanthosis nigricans independently predicts hepatic fibrosis in people with type 2 diabetes in North India
Acanthosis nigricans (AN) is a skin condition characterized by hyperpigmentation and thickening, often found in individuals with insulin resistance. Despite this well-established association, the potential link between AN and hepatic fibrosis in people with type 2 diabetes (T2D) has yet to be thoroughly explored. (Source: Primary Care Diabetes)
Source: Primary Care Diabetes - January 19, 2024 Category: Primary Care Authors: Koel Dutta, Surya Prakash Bhatt, Swati Madan, Irshad Ahmad Ansari, Kanika Tyagi, Shivam Pandey, Anoop Misra Source Type: research
Phenotype and predictors of insulin independence in adults presenting with diabetic ketoacidosis: a prospective cohort study
Conclusions/interpretationThe predominant phenotype of adults presenting with a first episode of DKA in Cape Town, South Africa, was that of ketosis-prone type 2 diabetes. These individuals presented with obesity, acanthosis nigricans, negative antibodies and normal C-peptide and could potentially be weaned off insulin at follow-up. Classic type 1 diabetes (lower weight, antibody positivity, low or unrecordable C-peptide levels and long-term insulin dependence) was less common. The simple clinical sign of acanthosis nigricans is a strong predictor of insulin independence at 12 months and 5 years after initial presentation....
Source: Diabetologia - January 19, 2024 Category: Endocrinology Source Type: research
Bullous pemphigoid, malignant acanthosis nigricans, and erysipeloid carcinoma in a woman with gastric adenocarcinoma
Key Clinical MessageBullous pemphigoid did not follow the course of Gastric Carcinoma relapse and remisson, unlike the malignant acanthosis nigricans which was in alignment with the paraneoplastic effect of the Gastric Carcinoma.AbstractAcanthosis nigricans (AN) is a dermatosis characterized by the presence of hyperpigmented, velvety cutaneous thickening in the flexural areas, posterior neck, and occasionally the extensor surfaces of hand, face, and oral mucosa. AN is commonly associated with insulin resistance, drugs, and rarely internal malignancy (malignant AN). Bullous pemphigoid (BP) is an autoimmune blistering diseas...
Source: Clinical Case Reports - January 3, 2024 Category: General Medicine Authors: Saman Al ‐Zahawi,
Yasaman Sadeghi,
Vahidesadat Azhari,
Hamidreza Mahmoudi,
Maryam Daneshpazhooh Tags: CASE REPORT Source Type: research
Generalized Acanthosis Nigricans due to Long Use of Steroids in Pemphigus Foliaceous Patient
Dermatitis. 2023 Nov 21. doi: 10.1089/derm.2023.0234. Online ahead of print.NO ABSTRACTPMID:38011039 | DOI:10.1089/derm.2023.0234 (Source: Dermatitis)
Source: Dermatitis - November 27, 2023 Category: Dermatology Authors: Mohammad El Darouti Hadeer Khedr Riham Mohiey El Din Ahmed Mourad Hagar El Sayed Source Type: research
Manifestations and etiology of cutaneous findings in cases of morbid obesity
AbstractMorbid obesity is associated with a wide range of metabolic, infective, and organic disorders related to adipose tissue overload. While careful documentation of internal autopsy findings is usual, skin manifestations may be overlooked. Skin manifestations are quite diverse and include striae distensae, skin tags, plantar hyperkeratosis, acanthosis nigricans, the sequelae of hyperandrogenism, lymphedema, panniculus morbidus, chronic venous insufficiency, stasis dermatitis, leg ulceration, intertrigo, cellulitis, pressure ulcers and ‘buried penis’. Obesity has also been associated with hidradenitis suppurativa, p...
Source: Forensic Science, Medicine, and Pathology - October 27, 2023 Category: Forensic Medicine Source Type: research
A Rare Case of Monogenic Obesity due to a Novel Variant in the ADCY3 Gene: Challenges in Follow-up and Treatment
J Clin Res Pediatr Endocrinol. 2023 Oct 19. doi: 10.4274/jcrpe.galenos.2023.2023-7-2. Online ahead of print.ABSTRACTAdenylate cyclase 3 (ADCY3) gene alterations have been found to be associated with obesity. However, few patients with homozygous mutations have been reported so far, and the follow-up procedure and treatment options have not been clarified. A 10-month-old female presented with increased appetite and weight gain. She was born from a consanguineous marriage. Weight, height, head circumference measurements and standard deviation scores (SDS) were 19 kg (+6.98 SDS), 82 cm (+3.53 SDS), and 49 cm (+3.07 SDS), resp...
Source: JCRPE Journal of Clinical Research in Pediatric Endocrinology - October 19, 2023 Category: Endocrinology Authors: Bahar Özcabı Asude Durmaz Ay ça Aykut Hasan Önal Samim Özen Source Type: research
