Oleic Acid as a Trigger for TLX-Mediated Neurogenesis

Neurogenesis is assessed in the hippocampus in most studies, connected to the processes of memory. Neurogenesis is the production of new neurons from neural stem cells and their integration into existing neural circuits. The areas of the brain responsible for memory must change, but it is an open question as to how much neurogenesis is going on elsewhere, and particularly in the adult human brain, where studies are far more limited than is the case for mice. Increased neurogenesis is thought to be generally beneficial to cognitive function at all ages, and it may be an important mechanism by which, for example, exercise improves memory and other capabilities. Beyond this, sizable increases in neurogenesis may be a path towards better maintenance of the aging brain, and recovery from injury, though this is more of an open question at the present time. Thus approaches capable of increasing neurogenesis are of interest to those of us who would like to be less impacted by the processes of aging. As yet, doing better than exercise is challenging, given the classes of mechanism and approach that are most explored. On the one hand, exercise and the production of butyrate by the gut microbiome lead to upregulation of BDNF, which promotes neurogenesis. On the other hand, SSRIs as a class of drug are known to increase neurogenesis, though with side-effects that make them undesirable for general use. In today's research materials, researchers find a way to trigger a regula...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs