Increased MYC expression without MYC gene translocation in patients with the diffuse large B-cell-lymphoma subtype of iatrogenic immunodeficiency-associated lymphoproliferative disorders
J Clin Exp Hematop. 2021;61(3):120-125. doi: 10.3960/jslrt.20025.ABSTRACTPost-transplant lymphoproliferative disorder (PTLD) and other iatrogenic immunodeficiency-associated lymphoproliferative disorders (OIIA-LPD) are iatrogenic lymphoproliferative disorders (LPD) that develop in association with immunosuppressive treatment in the setting of organ transplantation and autoimmune disease, respectively. Each has a spectrum of pathologies ranging from lymphoid hyperplasia to lymphoma. To clarify the characteristics of the diffuse large B-cell lymphoma (DLBCL) subtype in a cohort of 25 patients with PTLD or OIIA-LPD from our institute, we selected 13 with a histological subtype of DLBCL, including 2 cases of PTLD and 11 of OIIA-LPD. The median patient age at diagnosis was 70 years, with a female predominance. Both PTLD cases developed after kidney transplant. Of the patients with OIIA-LPD, 10 had rheumatoid arthritis, 1 had mixed connective tissue disease, and 8 were treated using methotrexate. Both of the PTLD patients and 6 of the OIIA-LPD patients had extranodal manifestations. All patients except for one were classified as having the non-germinal center B-cell (non-GCB) subtype according to the Hans algorithm. Tissue samples from 8 patients were positive for CD30 and 8 were positive for Epstein-Barr virus (EBV)-encoded small RNA. Seven patients had MYC-positive tissue samples, but none had MYC translocation. Our study suggests that extranodal manifestations and the non-GCB su...
Source: Journal of Clinical and Experimental Hematopathology : JCEH - Category: Hematology Authors: Nobuyuki Kabasawa Eisuke Shiozawa So Murai Mayumi Homma Yuka Uesugi Tomoharu Matsui Ayaka Nakata Shotaro Shimada Yohei Sasaki Yuta Baba Megumi Watanuki Nana Arai Shun Fujiwara Yukiko Kawaguchi Hiroyuki Tsukamoto Yui Uto Kouji Yanagisawa Norimichi Hattori Source Type: research
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