Arsenic exposure and human blood DNA methylation and hydroxymethylation profiles in two diverse populations from Bangladesh and Spain

CONCLUSIONS: While we identified common 5-hmC and 5-mC signatures in two populations exposed to varying levels of inorganic As, differences in As-related epigenetic sites across the study populations may additionally reflect low and high As-specific associations. This work contributes a deeper understanding of potential epigenetic dysregulations of As. However, further research is needed to confirm biological consequences associated with DIP2C epigenetic regulation and to investigate the role of 5-hmC and 5-mC separately in As-induced health disorders at different exposure levels.PMID:34516978 | DOI:10.1016/j.envres.2021.112021

Source: Environmental Research - September 13, 2021 Category: Environmental Health Authors: Arce Domingo-Relloso Anne Bozack Samara Kiihl Zulema Rodriguez-Hernandez Pilar Rentero-Garrido J Antonio Casasnovas Montserrat Leon-Latre Tamara Garcia-Barrera J Luis Gomez-Ariza Belen Moreno Ana Cenarro Griselda de Marco Faruque Parvez Abu B Siddique Has Source Type: research