Neuropsychiatric toxicity and cycloserine concentrations during treatment for multidrug-resistant tuberculosis

D-4-amino-3-isoxazolidinone, or D-cycloserine (cycloserine) was first discovered and synthesized by Hidy et al almost 70 years ago (Hidy et al., 1955). The neuropsychiatric toxicity (including depression and psychosis) was first reported with the earliest known use of cycloserine, and subsequent early treatment reports (Kendig et al., 1956; Murray, 1956). Cycloserine-associated peripheral neuropathy has been less frequently reported (Kendig et al., 1956; Murray, 1956; Desmeules et al., 1957; Conradie et al., 2014).

Source: International Journal of Infectious Diseases - March 5, 2021 Category: Infectious Diseases Authors: Richard Court, Chad M. Centner, Maxwell Chirehwa, Lubbe Wiesner, Paolo Denti, Nihal de Vries, Joseph Harding, Tawanda Gumbo, Gary Maartens, Helen McIlleron Source Type: research