Melatonin Inhibits Vascular Endothelial Cell Pyroptosis by Improving Mitochondrial Function via UQCRC1 Up-regulation and Demethylation.

In this study, melatonin attenuated the expression of pyroptosis-related genes, including NLRP3, caspase-1 and IL-1β, in human umbilical vein endothelial cells treated with oxidised low-density lipoprotein. Furthermore, melatonin up-regulated ten-eleven translocation 2 (TET2) expression, inhibited ubiquinol-cytochrome c reductase core protein 1 (UQCRC1) methylation and reduced pyroptosis. The up-regulation of UQCRC1 via melatonin improved mitochondrial function, thereby inhibiting oxidative stress and endothelial cell pyroptosis. Collectively, our results indicated that melatonin prevented endothelial cell pyroptosis by up-regulating TET2 to inhibit UQCRC1 methylation and improve mitochondrial function. PMID: 33332241 [PubMed - as supplied by publisher]
Source: Biochemistry and Cell Biology - Category: Biochemistry Authors: Tags: Biochem Cell Biol Source Type: research