How Much of Cognitive Decline is Actively Maintained via Dysfunctional Cell States or Signaling, and is thus Quickly Reversible?

Demonstrations in which researchers adjust cell state or signaling to reverse cognitive decline in old mice suggest that a meaningfully large fraction of this age-related cognitive decline is actively maintained via dysfunctions in cell signaling and cell activity. Senescent cells and their inflammatory signaling are a likely culprit, though it is challenging to join the dots between signaling and specific mechanisms inside cells in the highly complex environment of cellular biochemistry. The important point is that much of the decline in cognitive function could be quickly reversed if specific signals and mechanisms can be addressed. The work here is hopeful evidence on that front, though we should not forget that there remain the late stages of neurodegenerative conditions in which too much damage has been done, too many cells have died in the brain, for there to be a solution of this nature. Just a few doses of an experimental drug can reverse age-related declines in memory and mental flexibility in mice, according to a new study. The drug, called integrated stress response inhibitor (ISRIB), targeting eIF2α phosphorylation, has already been shown in laboratory studies to restore memory function months after traumatic brain injury (TBI), reverse cognitive impairments in Down Syndrome, prevent noise-related hearing loss, fight certain types of prostate cancer and even enhance cognition in healthy animals. In the new study, researchers showed rapid restoration of y...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs