Perfusion-guided sonopermeation of neuroblastoma: a novel strategy for monitoring and predicting liposomal doxorubicin uptake in vivo

Conclusion: Our results suggest that significant L-DOX uptake can occur by increasing tumor vascular permeability with microbubble sonopermeation without otherwise damaging the vasculature, as confirmed by in vivo qCEUS imaging and ex vivo analysis. The use of qCEUS imaging to monitor sonopermeation efficiency and predict drug uptake could potentially provide real-time feedback to clinicians for determining treatment efficacy in tumors, leading to better and more efficient personalized therapies. Finally, we demonstrate how the IGDD strategy outlined in this study could be implemented in human patients using a single case study.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Aditi Bellary, Arelly Villarreal, Rojin Eslami, Quincy J. Undseth, Bianca Lec, Ann M. Defnet, Naina Bagrodia, Jessica J. Kandel, Mark A. Borden, Sumbul Shaikh, Rajiv Chopra, Theodore W. Laetsch, Lauren J. Delaney, Colette M. Shaw, John R. Eisenbrey, Sonia Tags: Research Paper Source Type: research