Insights Into the Controversial Aspects of Adiponectin in Cardiometabolic Disorders
Horm Metab Res DOI: 10.1055/a-1239-4349In 2016, the World Health Organization estimated that more than 1.9 billion
adults were overweight or obese. This impressive number shows that weight excess
is pandemic. Overweight and obesity are closely associated with a high risk of
comorbidities, such as insulin resistance and its most important outcomes,
including metabolic syndrome, type 2 diabetes mellitus, and cardiovascular
disease. Adiponectin has emerged as a salutary adipocytokine, with
insulin-sensitizing, anti-inflammatory, and cardiovascular protective
properties. However, under metabolically unfavorable conditions, visceral
adipose tissue-derived inflammatory cytokines might reduce the transcription of
the adiponectin gene and consequently its circulating levels. Low circulating
levels of adiponectin are negatively associated with various conditions, such as
insulin resistance, type 2 diabetes mellitus, metabolic syndrome, and
cardiovascular disease. In contrast, several recent clinical trials and
meta-analyses have reported high circulating adiponectin levels positively
associated with cardiovascular mortality and all-cause mortality. These results
are biologically intriguing and counterintuitive, and came to be termed
“the adiponectin paradox”. Adiponectin paradox is frequently
associated with adipo...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Francischetti, Emilio Antonio Dezonne, R ômulo Sperduto Pereira, Cl áudia Maria de Moraes Martins, Cyro Jos é Celoria, Bruno Miguel Jorge de Oliveira, Patr ícia Aguiar Cardoso de Abreu, Virg ínia Genelhu Tags: Review Source Type: research
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