Cancers, Vol. 12, Pages 2481: Entosis: From Cell Biology to Clinical Cancer Pathology

Cancers, Vol. 12, Pages 2481: Entosis: From Cell Biology to Clinical Cancer Pathology Cancers doi: 10.3390/cancers12092481 Authors: Izabela Mlynarczuk-Bialy Ireneusz Dziuba Agnieszka Sarnecka Emilia Platos Magdalena Kowalczyk Katarzyna K. Pels Grzegorz M. Wilczynski Cezary Wojcik Lukasz P. Bialy Entosis is a phenomenon, in which one cell enters a second one. New clinico-histopathological studies of entosis prompted us to summarize its significance in cancer. It appears that entosis might be a novel, independent prognostic predictor factor in cancer histopathology. We briefly discuss the biological basis of entosis, followed by a summary of published clinico-histopathological studies on entosis significance in cancer prognosis. The correlation of entosis with cancer prognosis in head and neck squamous cell carcinoma, anal carcinoma, lung adenocarcinoma, pancreatic ductal carcinoma and breast ductal carcinoma, is shown. Numerous entotic figures are associated with a more malignant cancer phenotype and poor prognosis in many cancers. We also showed that some anticancer drugs could induce entosis in cell culture, even as an escape mechanism. Thus, entosis is likely beneficial for survival of malignant cells, i.e., an entotic cell can hide from unfavourable factors in another cell and subsequently leave the host cell remaining intact, leading to failure in therapy or cancer recurrence. Finally, we highlight the potential relationship of cell adhesion with e...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research