Genetic correlation, pleiotropy, and causal associations between substance use and psychiatric disorder.

CONCLUSIONS: Genetic etiology of substance use and psychiatric disorders is highly pleiotropic and involves shared neurodevelopmental path, neurotransmission, and intracellular trafficking. In aggregate, the patterns are not consistent with vertical pleiotropy, more likely reflecting horizontal pleiotropy or more complex forms of phenotypic causation. PMID: 32762793 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32762793?dopt=Abstract

Source: Psychological Medicine - August 6, 2020 Category: Psychiatry Authors: Jang SK, Saunders G, Liu M, 23andMe Research Team, Jiang Y, Liu DJ, Vrieze S Tags: Psychol Med Source Type: research