New oral anticoagulants for nonvalvular atrial fibrillation with peripheral artery disease: a meta-analysis.
CONCLUSION: The findings show that NOACs are effective and safe for preventing stroke/SE in patients with both NVAF and PAD. PMID: 32728781 [PubMed - as supplied by publisher]
CONCLUSION: The video laryngoscope occupies a prominent position in cases in which access to the airway is difficult. In the present case it was useful. It can be used as first choice or as a rescue technique. The video laryngoscope is an appropriate alternative and should be available for facing the ever-challenging difficult airway patient. PMID: 32736863 [PubMed - as supplied by publisher]
Publication date: Available online 22 July 2020Source: NeuroImage: ClinicalAuthor(s): Lena KL Oestreich, Paul Wright, Michael J O'Sullivan
HEART attack symptoms include difficulty breathing, severe chest pain, and feeling sick. But, you could also be at risk of a deadly myocardial infarction and heart disease if you develop a tell-tale painful sign in your stomach. Should you consider speaking to a doctor about heart attack signs?
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Abstract Intracerebral hemorrhage (ICH) is one of the most severe subtypes of stroke with high morbidity and mortality. Although a lot of drug discovery studies have been conducted, the drugs with satisfactory therapeutic effects for motor paralysis after ICH have yet to reach clinical application. Transient receptor potential vanilloid 4 (TRPV4), a Ca2+-permeable cation channel and activated by hypoosmolarity and warm temperature, is expressed in various cell types. The present study investigated whether TRPV4 would participate in the brain damage in a mouse model of ICH. ICH was induced by intrastriatal treatmen...
This study also demonstrated that TREM-1 expression was upregulated following cerebral infarction in rats. TREM-1 inhibition was determined using its selective inhibitor, LP17, which indicated a neuroprotective effect on cerebral infarction damage. The findings revealed that inhibition of TREM-1 by administering LP17 improved cerebral damage and decreased ischemic areas and brain water contents. Moreover, LP17 decreased MCAO-induced microglial activation and neurodegeneration, evidenced by a reduction in the expression of microglial Iba-1 and FJ-B positive cells, and reversed neuronal loss. Besides, the contribution of LP1...
(Elsevier) In a new study, investigators report that patients undergoing atrial fibrillation (AF) ablation, who are physically fit before the procedure, have a much higher chance of benefiting from the procedure and remaining in normal sinus rhythm. Less fit patients are rehospitalized more often, continue to use antiarrhythmic therapies longer, and have higher death rates than fitter patients. Their results appear in Heart Rhythm.
(University of Virginia Health System) An international team of scientists has completed the largest analysis of stroke-risk genes ever undertaken in people of African descent.
Authors: Zhang H, Xue Z, Yi D, Li X, Tan Y, Li J Abstract The efficacy and safety of non-vitamin K antagonist oral anticoagulants (NOACs) in atrial fibrillation (AF) with coronary or peripheral artery disease (CAD or PAD) remain largely unresolved. We, therefore, conducted a meta-analysis to explore the effect of NOACs compared with warfarin in these populations.We systematically searched the Cochrane Library, PubMed, and Embase databases for randomized controlled trials (RCTs) involving NOACs versus warfarin in AF patients with CAD or PAD. A random-effect model was selected to pool the risk ratios (RRs) and 95% co...