Copy Number Amplification of DNA Damage Repair Pathways Potentiates Therapeutic Resistance in Cancer

Conclusions: DDR gene amplification can lead to chemotherapy resistance and poor overall survival by augmenting DDR. These amplified DDR genes may serve as actionable clinical biomarkers for cancer management.

Source: Theranostics - July 3, 2020 Category: Molecular Biology Authors: Zhiyuan Wu, Sihan Li, Xuemei Tang, Yue Wang, Weiwei Guo, Guojun Cao, Kun Chen, Min Zhang, Ming Guan, Da Yang Tags: Research Paper Source Type: research