Ascorbic acid antagonizes the sedative effect of diazepam possibly through inhibition of GABA(A ρ₁) and GABA(B1) receptors.

In conclusion, DZP is a GABA receptor agonist and AA may reverse DZP-mediated sedative effects in a non-competitive binding fashion in mice through inhibition of GABA(Aρ₁) and GABA(B1) receptors. PMID: 32583769 [PubMed - in process]
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research