[18F]-3-Fluoro-4-amynopyridine, a novel radiotracer surrogate of myelin content in nonhuman primates

Conclusion: Similar to a previous study in other species [3], a higher uptake of 3F4AP in GM was observed as compared to WM in the brains of healthy nonhuman primates. The lower amount of myelin in GM and the higher number of potassium channels available for binding may explain the signal difference between the two types of cerebral tissues. A higher T1 value was also observed in GM as compared to WM, which is expected based on its known sensitivity to myelin content [5]. Overall, there was an excellent correspondence between the spatial distribution of 3F4AP and T1 map-derived intensity values, highlighting the potential of this combined approach for probing biological variations related to demyelination. There was also reasonable reproducibility of radiotracer uptake, which is promising for future quantification of 3F4AP uptake. In conclusion, our study illustrates the use of 3F4AP as a promising radiotracer surrogate of myelin integrity in the Callithrix jacchus, a relevant nonhuman primate model to study demyelinating diseases such as multiple sclerosis [6].

Source: Journal of Nuclear Medicine - May 14, 2020 Category: Nuclear Medicine Authors: Donadieu, M., Al-Louzi, O., Brugarolas, P., Wang, Z., Kelly, H., Shah, S., Ye, F., Zhang, X., Swenson, R., Popko, B., Jacobson, S., Hammoud, D., Sati, P., Reich, D. Tags: Basic Science - New tracers/analysis Source Type: research