Efficacy of Pleuran ( β-Glucan from Pleurotus ostreatus) in the Management of Herpes Simplex Virus Type 1 Infection.

Efficacy of Pleuran (β-Glucan from Pleurotus ostreatus) in the Management of Herpes Simplex Virus Type 1 Infection. Evid Based Complement Alternat Med. 2020;2020:8562309 Authors: Urbancikova I, Hudackova D, Majtan J, Rennerova Z, Banovcin P, Jesenak M Abstract One of the highly prevalent viral pathogens among children and adults causing infection, clinically presenting as herpes labialis, is herpes simplex virus type 1 (HSV-1). The long-term administration of acyclovir, a standard regimen for therapy against HSV-1 infections, can cause viral resistance against this drug. Therefore, the development of natural drugs with low toxicity that are able to enhance host antiviral defense against HSV infection is needed. β-Glucans represent a type of biologically active molecules possessing antiviral properties. The goal of this study was to investigate the clinical and immunomodulatory effect of β-glucan pleuran (insoluble β-1,3/1,6-D-glucan isolated from Pleurotus ostreatus) based supplements on the duration and intensity of herpes symptoms and on the incidence rate and duration of acute respiratory symptoms and intercurrent diseases in HSV-1 positive patients. Ninety patients were randomised into active and placebo groups. Active treatment with pleuran in systemic application caused a significantly shorter duration of herpes simplex symptoms compared to the placebo group. During the preventive phase (120 days), the duration and severity of re...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

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Publication date: Available online 4 July 2020Source: Integrative Medicine ResearchAuthor(s): Vincent C.H. Chung, Charlene H.L. Wong, Claire C.W. Zhong, Yan Yin Tjioe, Ting Hung Leung, Sian M. Griffiths
Source: Integrative Medicine Research - Category: Complementary Medicine Source Type: research
A 29  year old man, who has with sex with men, presented with 3 days fever of 39 Celsius degree and one day of severe pain during defecation. He had been on anti-retroviral treatment (dolutegravir, abacavir, lamivudine) for HIV infection for a year. CD4 count and HIV-RNA road were 708/µL and no detect ion. A month earlier, the patient had unsafe anal sexual contact with non-partner male. No abnormal finding in genital region, including ulcers and lymph node swelling, and pyuria were not observed on admission.
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Medical Imagery Source Type: research
Conclusion: Smoking hookah in healthy girls leads to changes in the cardio-respiratory system-the increase in clinical symptoms from the respiratory and cardiovascular system the transition of peak expiratory flow rate indicators to the signal zones.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Tobacco, smoking control and health educ. Source Type: research
Discussion Facial nerve palsy has been known for centuries, but in 1821 unilateral facial nerve paralysis was described by Sir Charles Bell. Bell’s palsy (BP) is a unilateral, acute facial paralysis that is clinically diagnosed after other etiologies have been excluded by appropriate history, physical examination and/or laboratory testing or imaging. Symptoms include abnormal movement of facial nerve. It can be associated with changes in facial sensation, hearing, taste or excessive tearing. The right and left sides are equally affected but bilateral BP is rare (0.3%). Paralysis can be complete or incomplete at prese...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
​Conjunctivitis is a common condition and easy enough to treat, but several uncommon conjunctivitis syndromes require more care and should not be missed.Conjunctivitis is either infectious (viral or bacterial) or noninfectious (allergic or nonallergic). Viral infections are more common in adults, bacterial ones in children, usually caused by Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis. Adults tend to have more S. aureus infections, while the other pathogens are more common in children. An adenovirus is typically responsible for viral-associated infections in conjunct...
Source: M2E Too! Mellick's Multimedia EduBlog - Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 009 The diagnosis of HIV is no longer fatal and the term AIDS is becoming less frequent. In many countries, people with HIV are living longer than those with diabetes. This post will hopefully teach the basics of a complex disease and demystify some of the potential diseases you need to consider in those who are severely immunosuppressed. While trying to be comprehensive this post can not be exhaustive (as you can imagine any patient with ...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine AIDS art cryptococcoma cryptococcus HIV HIV1 HIV2 PEP PrEP TB toxoplasma tuberculoma Source Type: blogs
Abstract In February 2012, a patient with a 15-year history of painful, pruritic eruptions presented with a severe exacerbation that had lasted for the previous week. The patient also reported severe headaches, a fever of 38.9°C (102.1°F), a cough, and diarrhea, which had now resolved. Physical examination showed erythematous macerated patches with erosions in the left submammary region, bilateral axillae, and vaginal area (Figure 1), and greasy scale covering the scalp. Despite lessening of the lesions in the submammary region and abdomen with the administration of minocycline 100 mg twice per day and cyc...
Source: Skinmed - Category: Dermatology Authors: Tags: Skinmed Source Type: research
A female child was referred to our institution at age 20  months after a protracted course of a febrile illness and cough associated with radiographic findings, demonstrating a large necrotic suprahilar lymph node impinging on the right main stem bronchus. Culture of the lymph node biopsy specimen, blood, and sputum identified Mycobacterium fortuitum an d Mycobacterium avium complex, whereas bronchoalveolar lavage specimen culture revealed the presence of Moraxella species. Other clinical findings included severe eczema for the first 6 months of life that was controlled by emollient use, development of chick...
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Letter to the Editor Source Type: research
Herpes simplex is a mucocutaneous infection that characteristically shows chronic and recurrent vesiculobullous or shallow ulcerative lesions. Two types of the herpes simplex virus are well known: HSV-1 and HSV-2. With the outbreak of AIDS, there has been an increment in the atypical clinical manifestations mainly because of the immunosuppression. Herein we report a case of a 53-year-old male patient admitted to investigate a giant ulcerated crusted 7 cm chin lesion. Clinically, the patient also presented productive cough for 2 months and weight loss.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Tags: CPP - Clinical Poster Presentation Source Type: research
Discussion Inflammation of the middle layer of the eye, or uvea, is termed uveitis. Uveitis can be divided into anterior, intermediate or posterior uveitis by involving the anterior (iris and ciliary body), intermediate (vitreous) or posterior (choroid and usually retina) compartments. Panuveitis involves all 3 compartments. Duration can also be used to classify uveitis. Acute is 6 weeks and> 3 months is chronic persistent uveitis. Episodic periods of inactivity and reactivity that last more than 3 months are called recurrent uveitis. A third way to characterize uveitis is if it is granulomatous or not. Uveitis increase...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
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