Polygenic risk scores indicates genetic overlap between peripheral pain syndromes and chronic postsurgical pain

In conclusion, this study is the first to report genetic overlap between regulatory processes implicated in CPSP and chronic peripheral pain syndromes. Interaction between neurological signalling and inflammatory res ponse may explain the genetic overlap between CPSP, CWP and RA. Enhanced understanding of mechanisms underlying chronification of pain will aid the development of new therapeutic strategies for CPSP with sodium channel biochemistry as a potential candidate.
Source: Neurogenetics - Category: Genetics & Stem Cells Source Type: research