The regulation of Niemann-Pick C1-Like 1 (NPC1L1) gene expression in opposite direction by Bacteroides spp. and related outer membrane vesicles in Caco-2 cell line

ConclusionThe opposite effect ofB. fragilis,B. thetaiotaomicron and related OMVs on theNPC1L1 gene expression was observed in Caco-2 cells. Interestingly, these effects partially were in line with the alternation ofLXRs expression. However, based on pathway enrichment analysis, further molecular investigations are required to elaborate in details the specific association betweenBacteroides spp. and OMVs with regulation of cholesterol signaling pathways including cholesterol transport, lipid storage, lipid homeostasis and cholesterol homeostasis.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research