Viruses, Vol. 12, Pages 416: Epstein –Barr Virus-Induced Post-Transplant Lymphoproliferative Disorder of the Central Nervous System Successfully Treated with Chemo-immunotherapy

We report here a rare case of post-transplant lymphoproliferative disorder (PTLD) associated with Epstein–Barr virus (EBV) reactivation in a 30-year-old female patient who underwent allogeneic HSCT for severe aplastic anemia. The PTLD, which was diagnosed 230 days after transplantation, was localized exclusively in the central nervous system (specifically in the choroid plexus) and manifested with obvious signs of intracranial hypertension. After receiving three cycles of high dose methotrexate (HD-MTX) combined with rituximab, the patient achieved a complete clinical recovery with normalization of blood cell counts, no evidence of EBV reactivation, and no associated neurotoxicity.

Source: Viruses - April 7, 2020 Category: Virology Authors: Hiroaki Inoue Shinya Rai Hirokazu Tanaka J. Luis Espinoza Maiko Komori-Inoue Hiroaki Kakutani Shuji Minamoto Takahiro Kumode Shoko Nakayama Yasuhiro Taniguchi Yasuyoshi Morita Takeshi Okuda Yoichi Tatsumi Takashi Ashida Itaru Matsumura Tags: Case Report Source Type: research