Subtype ‐specific cardiomyocytes for precision medicine: where are we now?

Generation of subtype ‐specific cardiomyocytes for modeling cardiovascular disease and precision medicine. AbstractPatient ‐derived pluripotent stem cells (PSCs) have greatly transformed the current understanding of human heart development and cardiovascular disease. Cardiomyocytes derived from personalized PSCs are powerful tools for modeling heart disease and performing patient‐based cardiac toxicity testing. Howe ver, these PSC‐derived cardiomyocytes (PSC‐CMs) are a mixed population of atrial‐, ventricular‐, and pacemaker‐like cells in the dish, hindering the future of precision cardiovascular medicine. Recent insights gleaned from the developing heart have paved new avenues to refine subtype‐spe cific cardiomyocytes from patients with known pathogenic genetic variants and clinical phenotypes. Here, we discuss the recent progress on generating subtype‐specific (atrial, ventricular, and nodal) cardiomyocytes from the perspectives of embryonic heart development, and how they will expand our current knowledge on molecular mechanisms of cardiovascular disease and the future of precision medicine.© AlphaMed Press 2020Significance StatementThis review article summarizes the recent process on how to generate chamber ‐specific cardiomyocytes from human pluripotent stem cells from the perspectives of developmental biology. Precise generation of atrial‐, ventricular‐, and pacemaker‐like cardiomyocytes will greatly facilitate the translational application...
Source: Stem Cells - Category: Stem Cells Authors: Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research