Cell proliferation and neurogenesis alterations in Alzheimer ’s disease and diabetes mellitus mixed murine models

To study the role of metabolic alterations in Alzheimer ´s disease, we analyzed cell proliferation and neurogenesis using 5’‐bromo‐2’‐deoxyuridine and doublecortin immunohistochemistry in three different mouse models of AD and metabolic alterations: APP/PS1xdb/db mice, APP/PS1 mice on long‐term high‐fat diet, and APP/PS1 mice treated with streptozotocin. Cell proliferation and neurogenesis were reduced after streptozotocin administration, while an increase in cell proliferation and neurogenesis was detected in neurogenic niches from APP/PS1xdb/db mice at 14 and 26 weeks of age. Interestingly, metabolic parameters body weight, glucose , and insulin are reliable predictors for cell proliferation and neurogenesis in APP/PS1xdb/db mice. AbstractThe classic neuropathological features of Alzheimer's disease (AD) are accompanied by other complications, including alterations in adult cell proliferation and neurogenesis. Moreover recent studies have shown that traditional markers of the neurogenic process, such as doublecortin (DCX), may also be expressed in CD8+ T cells and ionized calcium ‐binding adaptor molecule 1 (Iba1+) microglia, in the close proximity to senile plaques, increasing the complexity of the condition. Altered glucose tolerance, observed in metabolic alteratioins, may accelerate the neurodegenerative process and interfere with normal adult cell proliferation and neurogenesis. To further explore the role of metabolic disease in AD, we analyzed cell p...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research