How Artificial Intelligence Can Help Pick the Best Depression Treatments for You

Seeking out help for depression is hard enough. It doesn’t make things any easier that it can take weeks, months or longer of trying different treatments to find something that works. Doctors typically start patients on antidepressants, but they take at least four weeks to start working, and research has shown that only about 30% respond well to the first drug they’re prescribed. “Right now, treatment selection is purely based on trial and error,” says Dr. Madhukar Trivedi, a professor of psychiatry at the University of Texas Southwestern Medical Center. But promising new research published in February in Nature Biotechnology suggests that a simple brain test, paired with insights from artificial intelligence (AI), can predict whether an antidepressant will work on a given patient. Trivedi and a team of researchers took data from a previous study in which more than 200 people with depression had an electroencephalogram (EEG)—a non-invasive test that records a person’s brain waves through electrodes placed on their scalp—and were then given either sertraline (a widely prescribed antidepressant marketed as Zoloft) or a placebo for eight weeks. If those who responded well to sertraline shared a common brain-wave pattern, that might provide a big clue for whether or not any individual will respond to the drug. Trivedi and the team created a machine learning algorithm designed to analyze the EEG data, and it found that 65% of the study pa...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Artificial Intelligence medicine mental health onetime psychiatry Source Type: news

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Abstract BACKGROUND: Alexithymia (difficulties in identifying and describing emotion) is a transdiagnostic trait implicated in social-emotional and mental health problems in the general population. Many autistic individuals experience significant social-communication difficulties and elevated anxiety/depression and alexithymia. Nevertheless, the role of alexithymia in explaining individual variability in the quality/severity of social-communication difficulties and/or anxiety and depression symptoms in autism remains poorly understood. METHODS: In total, 337 adolescents and adults (autism N = 179) were assess...
Source: Psychological Medicine - Category: Psychiatry Authors: Tags: Psychol Med Source Type: research
Victoria Rodr íguez-Roldán, The Intersection between Disability and LGBT Discrimination and Marginalization, 28 (3) Am. U. J. Gender 2 (2020): In February of 2016, Kayden Clarke, a 24-year old autistic, transgender man in Mesa, Arizona, allegedly experienced a suicidal crisis. As...
Source: HealthLawProf Blog - Category: Medical Law Authors: Source Type: blogs
Abstract The human leukocyte antigen (HLA) is a complex genetic system that encodes proteins which predominantly regulate immune/inflammatory processes. It can be involved in a variety of immuno-inflammatory disorders ranging from infections to autoimmunity and cancers. The HLA system is also suggested to be involved in neurodevelopment and neuroplasticity, especially through microglia regulation and synaptic pruning. Consequently, this highly polymorphic gene region has recently emerged as a major player in the etiology of several major psychiatric disorders, such as schizophrenia, autism spectrum disorder and bi...
Source: Brain, Behavior, and Immunity - Category: Neurology Authors: Tags: Brain Behav Immun Source Type: research
Contributors : Annie Hien ; Gemma Molinaro ; Botao Liu ; Kimberly M Huber ; Joel D RichterSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusMetabotropic glutamate receptor-mediated long-term depression (mGluR-LTD) is a form of synaptic plasticity that is dysregulated in multiple mouse models of autism, including fragile X syndrome and tuberous sclerosis.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Abstract OBJECTIVE: Death by suicide is a highly preventable yet growing worldwide health crisis. To date, there has been a lack of adequately powered genomic studies of suicide, with no sizable suicide death cohorts available for analysis. To address this limitation, the authors conducted the first comprehensive genomic analysis of suicide death using previously unpublished genotype data from a large population-ascertained cohort. METHODS: The analysis sample comprised 3,413 population-ascertained case subjects of European ancestry and 14,810 ancestrally matched control subjects. Analytical methods included ...
Source: The American Journal of Psychiatry - Category: Psychiatry Authors: Tags: Am J Psychiatry Source Type: research
DiscussionIt is expected that participants in the ACAT group will significantly increase their self-understanding and awareness of ASD symptoms compared to those in the TAU group. Additionally, the ACAT group is expected to exhibit improved social adaptation and mental health if children and parents are able to better understand the ASD characteristics through sessions. This intervention will contribute to the establishment of an effective evidence-based treatment strategy for adolescents with ASD.Trial registrationUMIN Register000029851. Registered on January 06, 2018
Source: Trials - Category: Research Source Type: clinical trials
"Straight Sex is Complicated Enough!": The Lived Experiences of Autistics Who are Gay, Lesbian, Bisexual, Asexual, or Other Sexual Orientations. J Autism Dev Disord. 2020 Sep 23;: Authors: Lewis LF, Ward C, Jarvis N, Cawley E Abstract Autistics are more likely than neurotypicals to be gay, lesbian, bisexual, asexual, and other sexual orientations. Autistics and sexual minorities represent populations at high risk for depression, anxiety, and suicidality. Little is known about the experiences of individuals living at this intersection. In this phenomenology, 67 individuals who identified as a...
Source: Journal of Autism and Developmental Disorders - Category: Psychiatry Authors: Tags: J Autism Dev Disord Source Type: research
CONCLUSIONS.—: Because the death of autistic individuals is often because of an accident, drowning, suicide, or sudden unexpected death in epilepsy, they often are seen in a Medical Examiner's or Coroner's office. Yet, autism is rarely considered when evaluating the cause of death. Advances in our understanding of chronic traumatic encephalopathy have occurred because medical examiners and neuropathologists questioned whether a pathologic change might exist in individuals who played contact sports and later developed severe behavioral problems. This article highlights the potential for equally significant breakthroug...
Source: Archives of Pathology and Laboratory Medicine - Category: Laboratory Medicine Authors: Tags: Arch Pathol Lab Med Source Type: research
Abstract Neuronal growth regulator 1 (NEGR1) is a GPI-anchored membrane protein that is involved in neural cell adhesion and communication. Multiple genome wide association studies have found that NEGR1 is a generic risk factor for multiple human diseases, including obesity, autism, and depression. Recently, we reported that Negr1-/- mice showed a highly increased fat mass and affective behavior. In the present study, we identified Na/K-ATPase, beta1-subunit (ATP1B1) as an NEGR1 binding partner by yeast two-hybrid screening. NEGR1 and ATP1B1 were found to form a relatively stable complex in cells, at least partial...
Source: BMB Reports - Category: Biochemistry Authors: Tags: BMB Rep Source Type: research
Irritability, a hallmark feature of the new DSM-5 category of disruptive mood dysregulation disorder (DMDD), is present in many pediatric disorders including attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), depressive and anxiety disorders, and autism spectrum disorders. Indeed, irritability is among the most common presenting complaints in child psychiatry1 and predicts long-term impairments including high suicidality and decreased education and income attainment.
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: Editorial Source Type: research
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