Metabolic inflammation - a role for hepatic inflammatory pathways as driver of comorbidities in non-alcoholic fatty liver disease (NAFLD)?

Non-alcoholic fatty liver disease (NAFLD) is a global and growing health concern. Emerging evidence points towards metabolic inflammation as a key process in the fatty liver that contributes to multiorgan morbidity. Key extrahepatic comorbidities that are influenced by NAFLD are type 2 diabetes, cardiovascular disease and impaired neurocognitive function. Importantly, the presence of non-alcoholic steatohepatitis (NASH) and advanced hepatic fibrosis increase the risk for systemic comorbidity in NAFLD.

Source: Gastroenterology - February 13, 2020 Category: Gastroenterology Authors: Nadine Gehrke, J örn M. Schattenberg Source Type: research