Circulating 25-hydroxyvitamin D concentration and cause-specific mortality in the Melbourne Collaborative Cohort Study

Publication date: Available online 30 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Alicia K Heath, Allison M Hodge, Peter R Ebeling, David Kvaskoff, Darryl W Eyles, Graham G Giles, Dallas R English, Elizabeth J WilliamsonAbstractVitamin D deficiency is associated with higher all-cause mortality, but associations with specific causes of death are unclear. We investigated the association between circulating 25-hydroxyvitamin D (25(OH)D) concentration and cause-specific mortality using a case-cohort study within the Melbourne Collaborative Cohort Study (MCCS). Eligibility for the case-cohort study was restricted to participants with baseline dried blood spot samples and no pre-baseline diagnosis of cancer. These analyses included participants who died (n = 2307) during a mean follow-up of 14 years and a sex-stratified random sample of eligible cohort participants (‘subcohort’, n = 2923). Concentration of 25(OH)D was measured using liquid chromatography-tandem mass spectrometry. Cox regression, with Barlow weights and robust standard errors to account for the case-cohort design, was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for cause-specific mortality in relation to 25(OH)D concentration with adjustment for confounders.Circulating 25(OH)D concentration was inversely associated with risk of death due to cancer (HR per 25 nmol/L increment = 0.88, 95% CI 0.78–0.99), particularly colorectal cancer (...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research