Molecules, Vol. 25, Pages 490: Nanomedicine and Immunotherapy: A Step Further towards Precision Medicine for Glioblastoma

Molecules, Vol. 25, Pages 490: Nanomedicine and Immunotherapy: A Step Further towards Precision Medicine for Glioblastoma Molecules doi: 10.3390/molecules25030490 Authors: Šamec Zottel Videtič Paska Jovčevska Owing to the advancement of technology combined with our deeper knowledge of human nature and diseases, we are able to move towards precision medicine, where patients are treated at the individual level in concordance with their genetic profiles. Lately, the integration of nanoparticles in biotechnology and their applications in medicine has allowed us to diagnose and treat disease better and more precisely. As a model disease, we used a grade IV malignant brain tumor (glioblastoma). Significant improvements in diagnosis were achieved with the application of fluorescent nanoparticles for intraoperative magnetic resonance imaging (MRI), allowing for improved tumor cell visibility and increasing the extent of the surgical resection, leading to better patient response. Fluorescent probes can be engineered to be activated through different molecular pathways, which will open the path to individualized glioblastoma diagnosis, monitoring, and treatment. Nanoparticles are also extensively studied as nanovehicles for targeted delivery and more controlled medication release, and some nanomedicines are already in early phases of clinical trials. Moreover, sampling biological fluids will give new insights into glioblastoma pathogenesis due to the presence...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research

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Conclusions Symptom management in conjunction with PBT comprises a process of action, thoughts, and emotions. The concepts that emerged indicated patients' symptom management strategies were based on their own resources. Implications for Practice It is important that PBT facilities develop an approach that facilitates the symptom management process based on patients' experiences of symptoms, as well as their actions and available resources.
Source: Cancer Nursing - Category: Nursing Tags: ARTICLES: ONLINE ONLY Source Type: research
Conditions:   Surgical Site Infection;   Brain Tumor Intervention:   Other: infection prevention bundle Sponsor:   Istanbul University-Cerrahpasa Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Hannon MJ, Thompson CJ Abstract Hyponatremia is a frequent occurrence in patients with neurosurgical disorders. Acute onset hyponatremia is particularly common in patients who have any type of cerebral insult, including traumatic brain injury, subarachnoid hemorrhage, and brain tumors. Furthermore, it is a common complication of intracranial procedures. Acute hyponatremia creates an osmotic gradient between the brain and the plasma, which promotes the movement of water from the plasma into brain cells, causing cerebral edema and neurological compromise. It is therefore far more likely to be symptomatic, an...
Source: Frontiers of Hormone Research - Category: Endocrinology Tags: Front Horm Res Source Type: research
Source: Journal of Computational and Theoretical Nanoscience - Category: Nanotechnology Authors: Tags: research-article Source Type: research
(University of Missouri-Columbia) A retrospective study from the University of Missouri School of Medicine and MU Health Care showed patients who underwent surveillance imaging after surgery for brain tumor resection did not have better outcomes than patients who did not have imaging and returned when they felt symptoms of recurrence.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
(InSilico Medicine) New AI-powered discovery generative biology and generative chemistry effort targeting brain tumors with the focus on GBM launches at Insilico Medicine.
Source: EurekAlert! - Biology - Category: Biology Source Type: news
Conclusions: Percentage of signal recovery shows low recovery values in metastases, intermediate recovery values in glioma, and overshoot in lymphoma. PSR values show lower overlap than rCBV between lymphoma and metastases; and between high grade glioma and metastases. PSR difference is also higher than rCBV between low- and high-grade gliomas. Hence, PSR can potentially help as an additional perfusion parameter in the preoperative differentiation of these tumors.
Source: Indian Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research
llis Di C.o Medulloblastoma (MB) is the most common malignant brain tumor in children, and it is classified into four biological subgroups: WNT, Sonic Hedgehog (SHH), Group 3 and Group 4. The current treatment is surgery, followed by irradiation and chemotherapy. Unfortunately, these therapies are only partially effective. Citron kinase protein (CITK) has been proposed as a promising target for SHH MB, whose inactivation leads to DNA damage and apoptosis. D283 and D341 cell lines (Group 3/Group 4 MB) were silenced with established siRNA sequences against CITK, to assess the direct effects of its loss. Next, D283, D...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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Source: Expert Opinion on Drug Metabolism and Toxicology - Category: Drugs & Pharmacology Authors: Source Type: research
by Jill A. Gallaher, Susan C. Massey, Andrea Hawkins-Daarud, Sonal S. Noticewala, Russell C. Rockne, Sandra K. Johnston, Luis Gonzalez-Cuyar, Joseph Juliano, Orlando Gil, Kristin R. Swanson, Peter Canoll, Alexander R. A. Anderson Glioblastomas are aggressive primary brain tumors known for their inter- and intratumor heterogeneity. This disease is uniformly fatal, with intratumor heterogeneity the major reason for treatment failure and recurrence. Just like the nature vs nurture debate, heterogeneity can arise from intrinsi c or environmental influences. Whilst it is impossible to clinically separate observed behavior of c...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
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