Molecules, Vol. 25, Pages 490: Nanomedicine and Immunotherapy: A Step Further towards Precision Medicine for Glioblastoma

Molecules, Vol. 25, Pages 490: Nanomedicine and Immunotherapy: A Step Further towards Precision Medicine for Glioblastoma Molecules doi: 10.3390/molecules25030490 Authors: Šamec Zottel Videtič Paska Jovčevska Owing to the advancement of technology combined with our deeper knowledge of human nature and diseases, we are able to move towards precision medicine, where patients are treated at the individual level in concordance with their genetic profiles. Lately, the integration of nanoparticles in biotechnology and their applications in medicine has allowed us to diagnose and treat disease better and more precisely. As a model disease, we used a grade IV malignant brain tumor (glioblastoma). Significant improvements in diagnosis were achieved with the application of fluorescent nanoparticles for intraoperative magnetic resonance imaging (MRI), allowing for improved tumor cell visibility and increasing the extent of the surgical resection, leading to better patient response. Fluorescent probes can be engineered to be activated through different molecular pathways, which will open the path to individualized glioblastoma diagnosis, monitoring, and treatment. Nanoparticles are also extensively studied as nanovehicles for targeted delivery and more controlled medication release, and some nanomedicines are already in early phases of clinical trials. Moreover, sampling biological fluids will give new insights into glioblastoma pathogenesis due to the presence of ex...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research