Autologous stem cell transplantation for progressive systemic sclerosis: a prospective non-interventional study from the European Society for Blood and Marrow Transplantation Autoimmune Disease Working Party.

This study confirms the efficacy of autologous stem cell transplantation in real-life practice for severe systemic sclerosis using non myeloablative conditioning. Careful cardio-pulmonary assessment to identify organ involvement at patient referral, reduced cyclophosphamide doses and CD34+ selection may improve outcomes. The study was registered at ClinicalTrials.gov: NCT02516124. PMID: 31949011 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31949011?dopt=Abstract

Source: Haematologica - January 15, 2020 Category: Hematology Authors: Henes J, Oliveira MC, Labopin M, Badoglio M, Scherer HU, Del Papa N, Daikeler T, Schmalzing M, Schroers R, Martin T, Pugnet G, Simoes B, Michonneau D, Marijt EWA, Lioure B, Bay JO, Snowden JA, Rovira M, Huynh A, Onida F, Kanz L, Marjanovic Z, Farge D Tags: Haematologica Source Type: research