The Role of Cardiac T-Cadherin in the Indicating Heart Failure Severity of Patients with Non-Ischemic Dilated Cardiomyopathy.

Conclusions: Univariate Cox regression analysis did not prove T-cad to be an outcome predictor (HR = 1, p = 0.349). However, decreased T-cad levels in human myocardium can be an additional indicator of HF severity. T-cad in human myocardium has an anti-inflammatory role. More studies are needed to extend the role of T-cad in the outcome prediction of patients with NI-DCM. PMID: 31936691 [PubMed - in process]
Source: Medicina (Kaunas) - Category: Universities & Medical Training Authors: Tags: Medicina (Kaunas) Source Type: research

Related Links:

We present a case of recurrent ventricular tachycardia in a patient with dilated cardiomyopathy caused by a novel mutation of LMNA gene. Through electroanatomic mapping, catheter ablation and tissue pathology we provide detailed insights into this highly pathogenic inherited cardiomyopathy.
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: Review Source Type: research
.
Source: Epigenetics - Category: Genetics & Stem Cells Authors: Source Type: research
Authors: Yazaki M, Nabeta T, Inomata T, Ako J Abstract A 44-year-old man diagnosed with idiopathic dilated cardiomyopathy was admitted to our hospital with acute decompensated heart failure. Seven years before this admission, the first introduction of medication resulted in left ventricular (LV) recovery, which was sustained for several years. However, the patient stopped taking his medication, resulting in worsening of the LV function. Despite the second introduction of medication, the LV function did not improve. We performed cardiac magnetic resonance imaging and an endomyocardial biopsy, which revealed the sign...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
A 41-year-old man, with a history ACC/AHA stage C heart failure with reduced ejection fraction secondary to idiopathic dilated cardiomyopathy, presented at the HF clinic for follow-up visits, status post hospitalization due to acute decompensated heart failure in March 2019. After the initiation of milrinone during the hospitalization, two attempts to wean off milrinone were made but failed due to malperfusion and symptomatic hypotension with significant drops of the cardiac index to 1.3 L/min/m2 and 1.76 L/min/m2, respectively.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: 439 Source Type: research
AbstractBarth syndrome (BTHS) is a rare, X-linked recessive, infantile-onset debilitating disorder characterized by early-onset cardiomyopathy, skeletal muscle myopathy, growth delay, and neutropenia, with a worldwide incidence of 1/300,000 –400,000 live births. The high mortality rate throughout infancy in BTHS patients is related primarily to progressive cardiomyopathy and a weakened immune system. BTHS is caused by defects in the TAZ gene that encodes tafazzin, a transacylase responsible for the remodeling and maturation of the mi tochondrial phospholipid cardiolipin (CL), which is critical to normal mitochondrial...
Source: Heart Failure Reviews - Category: Cardiology Source Type: research
Abstract The clinical presentation of idiopathic dilated cardiomyopathy (IDCM) heart failure (HF) patients who will respond to medical therapy (responders) and those who will not (non-responders) is often similar. A machine learning (ML)-based clinical tool to identify responders would prevent unnecessary surgery, while targeting non-responders for early intervention. We used regional left ventricular (LV) contractile injury patterns in ML models to identify IDCM HF non-responders. MRI-based multiparametric strain analysis was performed in 178 test subjects (140 normal subjects and 38 IDCM patients), calculating l...
Source: Annals of Biomedical Engineering - Category: Biomedical Engineering Authors: Tags: Ann Biomed Eng Source Type: research
We report a case of a 30-year-old man who presented with advanced heart failure secondary to dilated cardiomyopathy. The patient was diagnosed with limb girdle muscular dystrophy type 2B (LGMD2B), a rare autosomal recessive disease. Cardiomyopathy is only rarely described in dysferlinopathies.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: 295 Source Type: research
An estimated 3.1 million cases of myocarditis/cardiomyopathy were diagnosed in 2017. Myocarditis, inflammation of the myocardium, is a leading cause of sudden death from heart failure in children and young adults worldwide. Patients can progress to dilated cardiomyopathy, heart and heart transplant. Studies have found that Vitamin D binding protein (DBP) could be instrumental in response to tissue injury and activation of the immune response. This chemotaxis activation has been shown to be due to activation of the complement cascade via C5a.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: 274 Source Type: research
to investigate prevalence, predictors, prognostic value of left ventricular reverse remodeling (LVRR) and relapse in patients hospitalized with dilated cardiomyopathy (DCM) from the initial center of heart failure (HF) in China.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: 269 Source Type: research
Dilated cardiomyopathy (DCM) is a common cause of heart failure (HF). Goal Directed Medical Therapy (GDMT) for HF has been shown to improve mortality and morbidity but rate of myocardial recovery is not well known.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: 258 Source Type: research
More News: Angiography | Cardiac Catheterization | Cardiology | Cardiomyopathy | Cardiovascular | Dilated Cardiomyopathy | Heart | Heart Failure | Heart Transplant | Laboratory Medicine | Study | Transplants | Universities & Medical Training