Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction.

Conclusions: These findings uncover a novel mechanism that contributes to lipid overload-induced heart hypertrophy and dysfunction. Excessive lipid supply created an intracellular environment that facilitated Drp1 acetylation, which, in turn, increased its activity and mitochondrial translocation, resulting in cardiomyocyte dysfunction and death. Thus, Drp1 may be a critical mediator of lipid overload-induced heart dysfunction as well as a potential target for therapy. PMID: 31896304 [PubMed - as supplied by publisher]
Source: Circulation Research - Category: Cardiology Authors: Tags: Circ Res Source Type: research

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In conclusion, non‐viral gene therapy to rBCECs leads to protein secretion and signifies a method for NPC2 to target cells inside the CNS otherwise inaccessible due to the pres ence of the BBB. However, obtaining high transfection efficiencies is crucial in order to achieve sufficient therapeutic effects.
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research
L-GILZ binds and inhibits nuclear factor κB nuclear translocation in undifferentiated thyroid cancer cells. J Chemother. 2020 Feb 18;:1-5 Authors: Marchetti MC, Cannarile L, Ronchetti S, Delfino DV, Riccardi C, Ayroldi E Abstract Proto-oncogene mutations and abnormal activation of mitogen-activated protein kinase (MAPK) signalling are recurrently found in thyroid cancers. Some thyroid neoplasms respond to drugs that inhibit MAPK pathway activation. Previously, we showed that pharmacological inhibition of MAPK in thyroid cancer cells inhibits cell proliferation and upregulates L-GILZ (long glucoco...
Source: Journal of Chemotherapy - Category: Cancer & Oncology Tags: J Chemother Source Type: research
Mol. Nutr. Food Res. 2020,64,https://doi.org/10.1002/mnfr.2019005501900550DOI:10.1002/mnfr.201900550Assembly of the NLRP3 inflammasome, consisting of ASC, NLRP3, and pro ‐caspase‐1, promotes neuroinflammation in neurological disorders. In articlehttps://doi.org/10.1002/mnfr.2019005501900550, Wei ‐Lun Hung, Chi‐Tang Ho, and Min‐Hsiung Pan summarize the pathogenic role of the NLRP3 inflammasome in neuroinflammation and highlight the current knowledge on the neuroprotective effects of phytochemicals for the treatment and prevention of neurological disorders through modulation of the NLRP 3 inflammasome.
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Front Cover Source Type: research
ConclusionsInsects display a diversity of TM ‐associated IgE reactivity. It is likely that minor sequence features and/or structural effects are primarily responsible. Additionally, we demonstrate that some insect species may present significantly less IgE cross‐reactivity to shrimp than do others.This article is protected by copyright. All rights reserved
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Research Article Source Type: research
Conclusion: People who are overweight or obese are motivated to lose weight because of health issues and feeling more comfortable with their body. The opportunities for weight loss lie in creating habits, routines and structuring everyday life activities to facilitate a healthier lifestyle.Significance: The findings indicate that an occupational therapist should be part of weight-loss interventions. PMID: 32065553 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Occupational Therapy - Category: Occupational Health Tags: Scand J Occup Ther Source Type: research
Publication date: Available online 19 February 2020Source: Small Ruminant ResearchAuthor(s): Ratan K. Choudhary, Jaspal S. Hundal, Manju Wadhwa, Shanti Choudhary, NeetikaAbstractPlant oil supplementation in animal diet is a reliable feeding strategy to enhance omega-3 fatty acids content in milk and meat. To investigate oil induced differential gene expressions of milk protein genes (LALBA, CSN2) and fat synthesis genes (CD36, XDH, ACACA, SCD, FABP3) in mammary epithelial cells, twelve Beetal goats were fed with control diet (CON) and linseed oil (LSO) or chia oil (CO) supplemented diets (1%) for sixty days. Total RNA was ...
Source: Small Ruminant Research - Category: Zoology Source Type: research
CONCLUSIONS: Elevated levels of sdLDL-C were associated with a higher prevalence of AIS, especially in non-cardioembolic stroke subtypes. After adjustment for other risk factors, sdLDL-C was found to be an independent risk factor for AIS. Also, sdLDL-C level was strongly associated with AIS severity and poor functional outcomes. Logistic regression models for AIS risk and prognosis prediction were established to help clinicians provide better prevention for high-risk subjects and monitor their prognosis. PMID: 32062644 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
Publication date: Available online 19 February 2020Source: Journal of Molecular StructureAuthor(s): S. Pangajavalli, R. Ranjithkumar, S. RamaswamyAbstractIn the present study, a novel 6b', 7', 8', 9'-Tetrahydro-2H,6'H-Spiro [acenaphthylene-1,11'-chromeno [3,4-a] pyrrolizine]-2,6'(6a'H,11a'H)- dione (ACPD) single crystal was grown by the slow evaporation method. The single crystal X-ray diffraction analysis and density functional theory (DFT) calculations were carried out for the ACPD molecule. The ACPD crystallizes in the orthorhombic space group Pbca with a = 18.3519 (14) Å, b = 11.3883 (9) Å, c = 18.3545 (14)...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
In this study, the enhanced mice live somewhat longer than their unmodified peers, though not as much longer as is the case for the application of telomerase gene therapy. The mice do also exhibit reduced cancer risk, however. The scientists here class telomere shortening as a cause of aging, which is not a point universally agreed upon. Reductions in average telomere length in tissues looks much more like a downstream consequence of reduced stem cell activity than an independent mechanism. Researchers obtain the first mice born with hyper-long telomeres and show that it is possible to extend life without any geneti...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling. Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/ Researchers her...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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