Gene Therapy with Single-Subunit Yeast NADH-Ubiquinone Oxidoreductase (NDI1) Improves the Visual Function in Experimental Autoimmune Encephalomyelitis (EAE) Mice Model of Multiple Sclerosis (MS)

In conclusion, targeting the dysfunctional complex I usingNDI1 gene can be an approach to address axonal and neuronal loss responsible for permanent disability in MS that is unaltered by current disease modifying drugs.
Source: Molecular Neurobiology - Category: Neurology Source Type: research

Related Links:

The objective of this study was to characterize AKI in dogs with babesiosis caused by Babesia rossi at presentation and after treatment. Thirty-five client-owned dogs with B. rossi infection and 10 control dogs were included in this prospective observational study. Blood and urine were collected in Babesia-infected dogs at presentation (T0, n = 35), after 24 hours (T24h, n = 11), and after 1 month (T1m, n = 9). The following urinary kidney injury biomarkers were assessed: urinary protein to creatinine ratio (UPC), urinary glomerular injury biomarkers (immunoglobulin G (uIgG)...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Publication date: Available online 19 February 2020Source: Journal of Molecular BiologyAuthor(s): Kan Wang, Jia-Qi Liu, Tao Zhong, Xiao-Ling Liu, Yan Zeng, Xinhua Qiao, Ting Xie, Yuzhe Chen, Ying-Ying Gao, Bo Tang, Jia Li, Jun Zhou, Dai-Wen Pang, Jie Chen, Chang Chen, Yi LiangAbstractCells have evolved molecular chaperones that modulate phase separation and misfolding of amyloidogenic proteins to prevent neurodegenerative diseases. Protein disulfide isomerase (PDI), mainly located at the endoplasmic reticulum and also present in the cytosol, acts as both an enzyme and a molecular chaperone. PDI is observed to be S-nitrosyl...
Source: Journal of Molecular Biology - Category: Molecular Biology Source Type: research
ConclusionThis study indicates that GSK-3 inactivation is dispensable for reloading-induced recovery of muscle mass and OXPHEN.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Publication date: Available online 19 February 2020Source: Life SciencesAuthor(s): Liu Yang, Xinyan Han, Jinfeng Yuan, Faping Xing, Zhixing Hu, Fei Huang, Hui Wu, Hailian Shi, Ting Zhang, Xiaojun WuAbstractAimsDendritic cells (DCs) actively participate in the pathogenesis of multiple sclerosis (MS), an autoimmune disease. Astragaloside IV (ASI), an active monomer isolated from the Chinese medicine Astragalus membranaceus, has a wide range of pharmacological effects. We aimed to elucidate the effects of ASI on the development of DCs in the early stage of MS/EAE.Main methodsThe mice were administered with ASI (20 mg/kg) da...
Source: Life Sciences - Category: Biology Source Type: research
Agreement gives BIA Separations access to proprietary technology to better preserve integrity, infectivity and potency of immunoaffinity-purified viral vectors for gene therapy
Source: The Scientist - Category: Science Tags: The Scientist The Marketplace Source Type: news
Publication date: March 2020Source: The Lancet Global Health, Volume 8, Issue 3Author(s): Charbel El Bcheraoui, Honoré Mimche, Yodé Miangotar, Varsha Sarah Krish, Faye Ziegeweid, Kris J Krohn, Martin Herbas Ekat, Jobert Richie Nansseu, Zacharie Tsala Dimbuene, Helen Elizabeth Olsen, Roger C K Tine, Christopher M Odell, Christopher E Troeger, Nicholas J Kassebaum, Tamer Farag, Simon I Hay, Ali H MokdadSummaryBackgroundPeer-reviewed literature on health is almost exclusively published in English, limiting the uptake of research for decision making in francophone African countries. We used results from the Globa...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
Publication date: March 2020Source: The Lancet Global Health, Volume 8, Issue 3Author(s): Anne Roca, Dominic Haslam OBE, Emma Jolley, Anna Ruddock, Elena Schmidt
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
BACKGROUND: There is a dearth of reliable data on sexual assault prevalence amongst people with learning disabilities. This work aims to identify the prevalence of learning disabilities amongst adult clients attending Saint Marys Sexual Assault Referral Ce...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Among Americans aged 65 years and older, falls are the leading cause of injury death and disability, and finding effective methods to prevent older adult falls has become a public health priority. While research has identified effective interventions deliv...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Condition:   Intellectual Disability Intervention:   Behavioral: Intervention with active video games Sponsors:   Hong Kong Baptist University;   Research Grants Council (RGC) of Hong Kong Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
More News: Adenoviruses | Autoimmune Disease | Brain | Disability | Ganglions | Gene Therapy | Genetics | Mitochondrial Disease | Multiple Sclerosis | Neurology | Vitamin A